Method for producing red perilla leaf extract

Patent metadata

Field	Value
Publication number	US-2022031790-A1
Application number	US-201917297299-A
Country	US
Kind code	A1
Filing date	Nov 26, 2019
Priority date	Nov 27, 2018
Publication date	Feb 3, 2022
Grant date	—

Abstract

Provided is a method for producing a red perilla leaf extract which enables to collect rosmarinic acid with a high yield from red perilla leaves to which an acid is added. The method for producing a red perilla leaf extract includes the following step (1): (1) a step of extracting red perilla leaves to which an acid has been added with water under a condition of a pH of from 4.0 to 8.0.

First claim

1 . A method for producing a red perilla leaf extract, the method comprising:
(1) extracting red perilla leaves to which an acid has been added with water under a condition of a pH of from 4.0 to 8.0.

2 . A method for producing a purified red perilla leaf extract, the method comprising:
(1) extracting red perilla leaves to which an acid has been added with water under a condition of a pH of from 4.0 to 8.0 to form an extract solution; (2) concentrating the extract solution obtained in the extracting (1) to form a concentrated extract solution; and (3) adding ethanol or an ethanol aqueous solution to the concentrated extract solution obtained in the concentrating (2) and then removing a precipitate.

3 . The producing method according to claim 1 , wherein an extraction temperature in the extracting (1) is 50° C. or more.

4 . The producing method according to claim 2 , wherein, in the step-extracting (1), a bath ratio of water is from 4 to 35 (L/kg).

5 . The producing method according to claim 2 , wherein, in the step adding (3), ethanol or an ethanol aqueous solution is added to the concentrated extract solution such that an ethanol concentration is from 40 to 95 vol %.

6 . The producing method according to claim 2 , wherein, in the concentrating (2), the pH of the extract solution obtained in the extracting (1) is further optionally adjusted to a pH of from 4.0 to 7.5 before the concentrating or the pH of the concentrated extract solution is further optionally adjusted to a pH of from 4.0 to 7.5 after the concentrating.

7 . The producing method according to claim 2 , wherein, in the adding (3), the concentrated extract solution has a pH of from 4.0 to 7.5.

Assignees

• Kao Corp

Inventors

• Takamura Akihiro
• Iwashita Masazumi
• Yamamoto Yuta
• Yamawaki Kenji
• Hashizume Kohjiro

Classifications

• A61P37/08

  Antiallergic agents (antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14) · CPC title

• A61P29/00

  Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title

• A61K2236/00

  Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine · CPC title

• A23L33/105 Primary

  Plant extracts, their artificial duplicates or their derivatives · CPC title

• A61K36/535 Primary

  Perilla (beefsteak plant) · CPC title