Dietary butyrate

Patent metadata

Field	Value
Publication number	US-2022023248-A1
Application number	US-201917413991-A
Country	US
Kind code	A1
Filing date	Dec 16, 2019
Priority date	Dec 17, 2018
Publication date	Jan 27, 2022
Grant date	—

Abstract

A compound having the formula (1), (2), (3) or (4), or combinations thereof, for use in the prevention or treatment of dehydration, and/or in the treatment of diarrhea, wherein R1, R2, R3, R4, R5 and R6 are independently, a long chain fatty acid having between 16 and 20 carbons.

First claim

1 . A method for the prevention or treatment of dehydration comprising administering a compound having a formula selected from the group consisting of

or combinations thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are independently, a long chain fatty acid having between 16 and 20 carbons to a subject in need of same

2 . A method according to claim 1 , wherein the compound or combinations thereof are for administration in combination with an oral rehydration solution (ORS).

3 . A method according to claim 1 , wherein the compound or combinations thereof are present in a form selected from the group consisting of an oral rehydration solution (ORS), a nutritional composition, a dietary supplement, an infant formula or a follow on-formula.

4 . An oral rehydration solution comprising a compound having the formula

or combinations thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are independently, a long chain fatty acid having between 16 and 20 carbons.

5 . An oral hydration solution according to claim 4 , further comprising a prebiotic.

6 . An oral rehydration solution according to claim 5 in the form of a powder for rehydration in a form selected from the group consisting of a liquid, a tablet for rehydration in a liquid, and a beverage.

7 . (canceled)

8 . A method according to claim 1 , wherein a combination of a compound having formula (1) and a compound having formula (2) is used.

9 . A method according to claim 1 , wherein a combination of a compound having formula (1) and a compound having formula (2) is used, and wherein the combination is present in a composition that comprises a compound having formula (1) in an amount of at least 10% by weight of the total butyrate moiety containing triglycerides in the composition, and a compound having formula (2) in an amount of at least 10% by weight of the total butyrate moiety containing triglycerides in the composition.

10 . A method according to claim 1 , wherein the compound having the formula (4) as the main butyrate moiety containing triglyceride in the composition, wherein the compound of formula (4) provides at least 20%, by weight of the butyrate moiety containing triglycerides in the composition.

11 . A method according to claim 1 , wherein a combination of a compound having formula (1), a compound having formula (2), a compound having formula (3) and a compound having formula (4) is used.

12 . A method according to claim 1 , wherein R 1 , R 2 , R 3 , R 4 , R 5 and/or R 6 is selected from the group consisting of oleic acid, palmitic acid, and linoleic acid.

13 . A method according to claim 1 , wherein each of R 1 , R 2 , R 3 , R 4 , R 5 and R 6 is oleic acid.

14 . A method for treating diarrhea comprising administering a composition comprising compounds having the formulas

wherein the compound having formula (5) comprises at least 10% by weight of the total triglycerides in the composition, and wherein the compound having formula (6) comprises at least 10% by weight of the total triglycerides in the composition to an individual in need of same.

15 . A method according to claim 14 wherein the compound having formula (5) comprises at least 15% by weight of the total triglycerides in the composition, and wherein the compound having formula (6) comprises at least 20% by weight of the total triglycerides in the composition.

16 . A method according to claim 14 , wherein the composition is an oral hydration solution, a nutritional composition, an infant formula, a follow-on formula and a dietary supplement.

Assignees

• Nestle Sa

Inventors

• Forbes-Blom Elizabeth
• Kuslys Martinas
• Heine Ralf
• Patin Amaury

Classifications

• A61K31/23 Primary

  of acids having a carboxyl group bound to a chain of seven or more carbon atoms · CPC title

• A23P10/40

  free-flowing powder or instant powder, i.e. powder which is reconstituted rapidly when liquid is added (A23P10/20, A23P10/30 take precedence) · CPC title

• A23V2002/00

  Food compositions, function of food ingredients or processes for food or foodstuffs · CPC title

• A61P1/12

  Antidiarrhoeals · CPC title

• A23L33/40

  Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula · CPC title