Diagnosis and treatment of cancer expressing ILT3 or ILT3 ligand
US-9696312-B2 · Jul 4, 2017 · US
US2022019865A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2022019865-A1 |
| Application number | US-202016929238-A |
| Country | US |
| Kind code | A1 |
| Filing date | Jul 15, 2020 |
| Priority date | Jul 15, 2020 |
| Publication date | Jan 20, 2022 |
| Grant date | — |
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A system includes a processor and memory storing instructions that when executed by the processor configure the processor to receive an image of a metallographic sample of a product from a microscope, the image including dendritic structures in the metallographic sample; select a portion of the image; and perform morphological operations on the selected portion of the image to transform the image. The instructions configure the processor to overlay a plurality of concentric circles on the transformed image, measure circumferences of the circles, and count the number of intercepts of the circles and boundaries of the dendritic structures in the transformed image. The instructions configure the processor to determine parameters of the dendritic structures based on the measured circumferences and the number of intercepts. The instructions configure the processor to determine structural properties of the product based on the parameters of the dendritic structures.
Opening claim text (preview).
What is claimed is: 1 . A system comprising: a processor; and memory storing instructions that when executed by the processor configure the processor to: receive an image of a metallographic sample of a product from a microscope, the image including dendritic structures in the metallographic sample; select a portion of the image; perform morphological operations on the selected portion of the image to transform the image; overlay a plurality of concentric circles on the transformed image; measure circumferences of the circles; count the number of intercepts of the circles and boundaries of the dendritic structures in the transformed image; determine parameters of the dendritic structures based on the measured circumferences and the number of intercepts; and determine structural properties of the product based on the parameters of the dendritic structures. 2 . The system of claim 1 wherein a process used to manufacture the product is selectively adjusted based on the determined structural properties. 3 . The system of claim 1 wherein a composition of material used to manufacture the product is selectively adjusted based on the determined structural properties. 4 . The system of claim 1 wherein the instructions configure the processor to determine the parameters independent of a magnification of the microscope. 5 . The system of claim 1 wherein the instructions configure the processor to determine the parameters independent of a resolution of a camera used to capture the image. 6 . The system of claim 1 wherein the instructions configure the processor to adjust one or more of the circumferences based on a distribution of the dendritic structures in the selected portion of the image. 7 . The system of claim 1 wherein the parameters include a dendritic cell spacing for the metallographic sample and wherein the instructions configure the processor to determine the dendritic cell spacing by dividing a sum of the circumferences by the number of intercepts. 8 . The system of claim 1 wherein the parameters include a mean linear dendritic spacing for the metallographic sample and wherein the instructions configure the processor to determine the mean linear dendritic spacing based on the circumferences and the number of intercepts. 9 . The system of claim 7 wherein the parameters include a mean linear dendritic spacing for the metallographic sample and wherein the instructions configure the processor to determine the mean linear dendritic spacing based on the dendritic cell spacing. 10 . The system of claim 7 wherein the parameters include a mean linear dendritic spacing for the metallographic sample and wherein the instructions configure the processor to determine the mean linear dendritic spacing based on the dendritic cell spacing and an area of the selected portion of the image. 11 . A system comprising: a plurality of microscopes having different magnifications and including cameras having different resolutions; and a computing device configured to: receive an image of a metallographic sample of a product captured by one of the cameras of any one of the microscopes at any one of the magnifications, the image including dendritic structures in the metallographic sample; select a portion of the image; perform morphological operations on the selected portion of the image to transform the image; overlay a plurality of concentric circles on the transformed image; measure circumferences of the circles; count the number of intercepts of the circles and boundaries of the dendritic structures in the transformed image; determine parameters of the dendritic structures based on the measured circumferences and the number of intercepts; and determine structural properties of the product based on the parameters of the dendritic structures. 12 . The system of claim 11 wherein a process used to manufacture the product is selectively adjusted based on the determined structural properties. 13 . The system of claim 11 wherein a composition of material used to manufacture the product is selectively adjusted based on the determined structural properties. 14 . The system of claim 11 wherein the computing device is configured to determine the parameters independent of the magnifications of the microscopes. 15 . The system of claim 11 wherein the computing device is configured to determine the parameters independent of the resolutions of the cameras. 16 . The system of claim 11 wherein the computing device is configured to adjust one or more of the circumferences based on a distribution of the dendritic structures in the selected portion of the image. 17 . The system of claim 11 wherein the parameters include a dendritic cell spacing for the metallographic sample and wherein the computing device is configured to determine the dendritic cell spacing by dividing a sum of the circumferences by the number of intercepts. 18 . The system of claim 11 wherein the parameters include a mean linear dendritic spacing for the metallographic sample and wherein the computing device is configured to determine the mean linear dendritic spacing based on the circumferences and the number of intercepts. 19 . The system of claim 18 wherein the parameters include a mean linear dendritic spacing for the metallographic sample and wherein the computing device is configured to determine the mean linear dendritic spacing based on the dendritic cell spacing. 20 . The system of claim 18 wherein the parameters include a mean linear dendritic spacing for the metallographic sample and wherein the computing device is configured to determine the mean linear dendritic spacing based on the dendritic cell spacing and an area of the selected portion of the image.
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