Sensing devices

Patent metadata

Field	Value
Publication number	US-2022018775-A1
Application number	US-202016931855-A
Country	US
Kind code	A1
Filing date	Jul 17, 2020
Priority date	Jul 17, 2020
Publication date	Jan 20, 2022
Grant date	—

Abstract

A sensing device includes a first sensor configured to capture a first analyte in a fluid medium and to generate a first signal in response to capturing the first analyte. The sensing device also includes a second sensor configured to capture a second analyte in the fluid medium and to generate a second signal in response to capturing the second analyte, where the second analyte is different from the first analyte. The sensing device further includes a detector configured to collect the first and second signals to provide a total signal and to calculate a total concentration of the first and the second analyte in the fluid medium based on the total signal.

First claim

What is claimed is:

1 . A sensing device comprising:
a first sensor configured to capture a first analyte in a fluid medium and to generate a first signal in response to capturing the first analyte; a second sensor configured to capture a second analyte in the fluid medium and to generate a second signal in response to capturing the second analyte, the second analyte being different from the first analyte; and a detector configured to collect the first and the second signal to provide a total signal and to calculate a total concentration of the first and the second analyte in the fluid medium based on the total signal.

2 . The sensing device of claim 1 , wherein the first sensor has a first receptor configured to capture the first analyte in the fluid medium, and further comprising a first spacer bound to the first receptor, a first fluorophore bound to the first spacer, and a first anchor bound to the first fluorophore.

3 . The sensing device of claim 2 , wherein the first fluorophore is selected from the group consisting of anthracene, benzene, carbazole, diphenylfurane, naphthalene, 1,8-naphthalimide, N,N,N′,N′-tetramethylbenzidine, porphyrin, and pyrene.

4 . The sensing device of claim 2 , wherein the first sensor is linked to a tethering matrix via the first anchor, the tethering matrix embedded with hydrogels, and the tethering matrix and the hydrogels being supported by a first polymer support.

5 . The sensing device of claim 4 , wherein the hydrogels are polyurethane or poly(2-hydroxyethyl methacrylate) (Poly-HEMA).

6 . The sensing device of claim 4 , wherein the first polymer support is polyethylene terephthalate (PET).

7 . The sensing device of claim 1 , wherein the second sensor has a second receptor configured to capture the second analyte in the fluid medium, and further comprising a second spacer bound to the second receptor, a second fluorophore bound to the second spacer, and a second anchor bound to the second fluorophore.

8 . The sensing device of claim 7 , wherein the second fluorophore is selected from the group consisting of anthracene, benzene, carbazole, diphenylfurane, naphthalene, 1,8-naphthalimide, N,N,N′,N′-tetramethylbenzidine, porphyrin, and pyrene.

9 . The sensing device of claim 7 , wherein the second sensor is linked to a tethering matrix via the second anchor, the tethering matrix embedded with hydrogels, and the tethering matrix and the hydrogels being supported by a second polymer support.

10 . The sensing device of claim 9 , wherein the hydrogels are polyurethane or poly(2-hydroxyethyl methacrylate) (Poly-HEMA).

11 . The sensing device of claim 9 , wherein the second polymer support is polyethylene terephthalate (PET).

12 . A sensing device comprising:
a sensor film having a mixture of sensors, the mixture of sensors including first and second sensors, the first and second sensors being mixed by a mixing ratio, each of the first and second sensors being configured to capture an analyte in a fluid medium having at least one analyte and to generate a signal in response to capturing the analyte; and a detector configured to collect signals from each of the first and second sensors upon each of the first and second sensors capturing one of the at least one analyte in the fluid medium to provide a total signal and to calculate a total concentration of the at least one analyte in the fluid medium based on the total signal.

13 . The sensing device of claim 12 , wherein the mixing ratio is in a range of 0.05 and 0.95.

14 . The sensing device of claim 12 , wherein each of the first and second sensors in the sensor film has a receptor configured to capture one of the at least one analyte in the fluid medium, and further comprising a spacer bound to the receptor, a fluorophore bound to the spacer, and an anchor bound to the fluorophore.

15 . The sensing device of claim 14 , wherein the fluorophore is selected from the group consisting of anthracene, benzene, carbazole, diphenylfurane, naphthalene, 1,8-naphthalimide, N,N,N′,N′-tetramethylbenzidine, porphyrin, and pyrene.

16 . A sensing device comprising:
a sensor film including a mixture of sensors, the mixture of sensors including first and second sensors, the first and second sensors being mixed by a mixing ratio, each of the first and second sensors being configured to capture an analyte in a fluid medium to generate a signal in response to capturing the analyte; a first detector configured to collect a first signal having a first frequency from at least one of the first and second sensors in the sensor film upon the at least one of the first and second sensors capturing a first analyte in the fluid medium and to calculate a first total concentration of the first analyte in the fluid medium based on the first signal; and a second detector configured to collect a second signal having a second frequency from at least another one of the first and second sensors in the sensor film upon the at least another one of the first and second sensors capturing a second analyte in the fluid medium and to calculate a second total concentration of the second analyte in the fluid medium based on the second signal, the second frequency being different from the first frequency.

17 . The sensing device of claim 16 , wherein the mixing ratio is in a range of 0.05 and 0.95.

18 . The sensing device of claim 16 , further comprising a first filter positioned between the sensor film and the first detector and configured to filter out the second signal, and a second filter positioned between the sensor film and the second detector and configured to filter out the first signal.

19 . The sensing device of claim 16 , wherein each of the first and second sensors in the sensor film has a receptor configured to capture one of the analyte in the fluid medium, and further comprising a spacer bound to the receptor, a fluorophore bound to the spacer, and an anchor bound to the fluorophore.

20 . The sensing device of claim 19 , wherein the fluorophore is selected from the group consisting of anthracene, benzene, carbazole, diphenylfurane, naphthalene, 1,8-naphthalimide, N,N,N′,N′-tetramethylbenzidine, porphyrin, and pyrene.

Assignees

• Bosch Gmbh Robert

Inventors

• Kornbluth Mordechai
• Sagar Kaushal
• Pant Shilpa

Classifications

• G01N33/1813 Primary

  Specific cations in water, e.g. heavy metals · CPC title

• G01N21/643 Primary

  non-biological material · CPC title

• G01N2021/6432

  Quenching · CPC title

• G01N33/1853

  Hardness of water · CPC title

• G01N31/22

  using chemical indicators (G01N31/02 takes precedence) · CPC title