Apparatus for testing a cardiac catheter utilizing live cardiac cells

Patent metadata

Field	Value
Publication number	US-2022016419-A1
Application number	US-202117370757-A
Country	US
Kind code	A1
Filing date	Jul 8, 2021
Priority date	Jul 16, 2020
Publication date	Jan 20, 2022
Grant date	—

Abstract

A medical tool testing apparatus comprising a vessel. The vessel comprises a scaffold formed from biomaterial, live cardiac tissue, generated from cardiac cells, proliferating on the scaffold, the live cardiac tissue configured to generate electrical activity. The vessel also comprises a medical tool, in contact with live cardiac tissue, used for a medical procedure within patient anatomy. Operational features of the medical tool are determined by a visually perceptible condition of the live cardiac tissue.

First claim

What is claimed is:

1 . A medical tool testing apparatus comprising:
a vessel comprising:
a scaffold formed from biomaterial;
live cardiac tissue, generated from cardiac cells, proliferating on the scaffold, the live cardiac tissue configured to generate electrical activity; and
a medical tool, in contact with live cardiac tissue, used for a medical procedure within patient anatomy,
wherein operational features of the medical tool are determined by a visually perceptible condition of the live cardiac tissue.

2 . The apparatus of claim 1 , wherein attributes of the visually perceptible condition are provided for display on a display device.

3 . The apparatus of claim 1 , further comprising at least one pacing electrode, in contact with the live cardiac tissue, configured to deliver an electrical pacing pulse to the live cardiac tissue.

4 . The apparatus of claim 3 , wherein the visually perceptible condition is generated in response to the electrical pacing pulse.

5 . The apparatus of claim 3 , further comprising an electrical pulse generator, wherein the at least one pacing electrode extends from the electrical pulse generator into the vessel.

6 . The apparatus of claim 1 , wherein the at least one pacing electrode is disposed on the medical tool.

7 . The apparatus of claim 1 , wherein the visually perceptible condition is at least one of a sinus rhythm wave and an arrythmia.

8 . The apparatus of claim 1 , where the medical tool comprises a plurality of recording electrodes configured to record attributes of the visually perceptible condition.

9 . The apparatus of claim 8 , wherein the medical tool is a cardiac catheter and the plurality of recording electrodes are spaced approximately equidistantly along a spline of a cardiac catheter.

10 . The apparatus as recited in claim 1 , further comprising a second cardiac catheter configured to provide energy to the live cardiac tissue and cause damage thereto to simulate a malfunction of a heart's electrical system.

11 . The apparatus of claim 1 , wherein the live cardiac tissue is human cardiac tissue.

12 . The apparatus of claim 1 , wherein the live cardiac tissue is animal cardiac tissue.

13 . A medical tool testing system comprising:
a vessel comprising:
a scaffold formed from biomaterial;
live cardiac tissue, generated from cardiac cells, proliferating on the scaffold, the live cardiac tissue configured to generate electrical activity; and
a medical tool, in contact with live cardiac tissue, used for a medical procedure within patient anatomy,
an electrical pulse generator configured to provide electrical pulses; at least one pacing electrode, electrically connected to the electric pulse generator and in contact with the live cardiac tissue, configured to deliver the electrical pulses to the live cardiac tissue as electrical pacing pulses; and a processor configured to provide attributes of a condition of the live cardiac tissue for display.

14 . The system of claim 13 , further comprising a display device configured to display the condition as attributes of one of a sinus rhythm wave and an arrythmia for determining whether or not at least one operational feature of the medical tool is providing accurate measurements.

15 . The system of claim 13 , wherein the at least one operational feature of the medical tool comprises a plurality of recording electrodes configured to record the attributes of the condition of the live cardiac tissue.

16 . The system of claim 13 , further comprising an image acquiring device configured to acquire images of the attributes of the condition of the live cardiac tissue.

17 . The system of claim 16 , further comprising a fluoroscopy imaging system which includes the image acquiring device.

18 . The system of claim 13 , wherein the at least one pacing electrode comprises a plurality of pacing electrodes that are spaced approximately equidistantly from each other and are in contact with the live cardiac tissue within the vessel.

19 . A method of testing a cardiac catheter under conditions replicating a beating heart, the method comprising:
delivering, by a plurality of pacing electrodes in contact with live cardiac tissue in a vessel, electrical pacing pulses to the live cardiac tissue; generating, by the live cardiac tissue, a condition of the live cardiac tissue in response to the electrical pacing pulses; recording, by recording electrodes disposed on a cardiac catheter in contact with the live cardiac tissue, attributes of the condition of the live cardiac tissue; and providing the attributes of the condition of the live cardiac tissue as attribute information for display.

20 . The method of claim 19 , further comprising:
generating electrical pulses; and delivering, by the plurality of pacing electrodes, the electrical pulses as the electrical pacing pulses to the live cardiac tissue.

Assignees

• Biosense Webster Israel Ltd

Inventors

• Zoubi Alaa
• Levy Nakdimon Nissim
• Bar-On Tal Haim
• Hayam Gal
• Hagla Wagdi Hani
• Eliyahu Shiran
• Turgeman Aharon
• Maydel Michael
• Itah Refael
• Botzer Lior
• Kdoshai Scliar Hen

Classifications

• A61N1/05 Primary

  for implantation or insertion into the body, e.g. heart electrode (A61N1/06 takes precedence) · CPC title

• A61N1/372

  Arrangements in connection with the implantation of stimulators · CPC title

• A61N2001/37294

  Means for testing medical devices within the package prior to implantation · CPC title

• A61N1/0563

  specially adapted for defibrillation or cardioversion · CPC title

• C12N2513/00

  3D culture · CPC title