Process monitoring and control during laser-based refractive index modification of intraocular lenses in patients

Patent metadata

Field	Value
Publication number	US-2022015948-A1
Application number	US-202017057689-A
Country	US
Kind code	A1
Filing date	Apr 7, 2020
Priority date	Apr 11, 2019
Publication date	Jan 20, 2022
Grant date	—

Abstract

Methods and related apparatus for real-time process monitoring during laser-based refractive index modification of an intraocular lens. During in situ laser treatment of the IOL to modify the refractive index of the IOL material, a signal from the IOL is measured to determine the processing effect of the refractive index modification, and based on the determination, to adjust the laser system parameters to achieve intended processing result. The signal measured from the IOL may be a fluorescent signal induced by the treatment laser, a fluorescent signal induced by an external illumination source, a temporary photodarkening effect, a color change, or a refractive index change directly measured by phase stabilized OCT.

First claim

What is claimed is:

1 . A method for real-time process monitoring during laser-based refractive index modification of an intraocular lens (IOL), comprising:
treating the IOL with a laser beam to modify a refractive index of the IOL at selected locations; while treating the IOL with the laser beam, measuring a signal from the IOL to determine a processing effect of refractive index modification of the IOL; and based on the determination, further treating the IOL with the laser beam.

2 . The method of claim 1 , wherein the signal measured from the IOL is a fluorescent signal induced by the treatment laser beam.

3 . The method of claim 1 , further comprises illuminating the IOL with an external illumination source, wherein the signal measured from the IOL is a fluorescent signal induced by the external illumination source.

4 . The method of claim 1 , further comprises illuminating the IOL with a light source, wherein the signal measured from the IOL is a temporary photodarkening effect.

5 . The method of claim 1 , further comprises illuminating the IOL with a broadband visible light source, wherein the signal measured from the IOL is a color change.

6 . The method of claim 1 , wherein measuring the signal from the IOL includes measuring a refractive index change of the IOL using phase stabilized swept-source OCT. The method of claim 1 , wherein the laser beam is a femtosecond pulsed laser beam.

8 . The method of claim 1 , wherein the IOL is formed of a crosslinked acrylic polymer.

9 . The method of claim 1 , wherein the step of treating the IOL with the laser beam to modify a refractive index of the IOL at selected locations includes scanning the laser beam within the IOL in a predefined scan pattern.

10 . The method of claim 9 , wherein the predefined scan pattern includes multiple concentric rings.

11 . The method of claim 10 , wherein the step of further treating the IOL with the laser beam includes scanning the laser beam within the IOL in selected portions of the multiple concentric rings.

12 . The method of claim 1 , wherein the step of further treating the IOL with the laser beam includes adjusting one or more parameters of the laser beam.

Assignees

• Amo Dev Llc

Inventors

• Hofer Richard
• Vankov Alexander
• Wang Jenny
• Dewey David A
• Gooding Phillip
• Schuele Georg

Classifications

• A61F2009/00851

  Optical coherence topography [OCT] · CPC title

• A61L2430/16

  for reconstruction of eye parts, e.g. intraocular lens, cornea · CPC title

• A61B2017/00154

  pulsed · CPC title

• A61B2017/00061

  spectrum · CPC title

• A61F9/00834 Primary

  Inlays; Onlays; Intraocular lenses [IOL] · CPC title