Meshed umbilical cord tissue grafts

Patent metadata

Field	Value
Publication number	US-2021393852-A1
Application number	US-202117350103-A
Country	US
Kind code	A1
Filing date	Jun 17, 2021
Priority date	Jun 19, 2020
Publication date	Dec 23, 2021
Grant date	—

Abstract

A meshed, dehydrated, umbilical tissue allograft that can be used in the treatment of wounds. Specifically, the meshed allograft has the property of being able to be expanded to cover an irregularly shaped wound, therefore reducing the need to apply multiple, uniform sized grafts to a single wound site. The meshed, dehydrated umbilical tissue allograft is sourced from a human donor, and is then processed to remove any potential contaminants or microbes prior to applying a specific mesh pattern to the tissue. The meshed, dehydrated, umbilical tissue graft is reconstituted prior to applying to the subject, and can then be configured to optimally cover the shape of the wound site.

First claim

What is claimed is:

1 . A meshed, expandable, and sterile umbilical tissue allograft.

2 . The umbilical tissue allograft of claim 1 , wherein said allograft comprises pre-determined cuts.

3 . The umbilical tissue allograft of claim 2 , wherein the cuts are in an engineered pattern.

4 . The umbilical tissue allograft of claim 3 , wherein all of said cuts are parallel to one another.

5 . The umbilical tissue allograft of claim 4 , wherein said cuts are 0.1-20 mm in length.

6 . The umbilical tissue allograft of claim 4 , wherein the distance between two adjacent cuts is between 0.1-10 mm.

7 . The umbilical tissue allograft of claim 3 , wherein a first portion of said cuts are parallel to one another, a second portion of said cuts are parallel to one another, and the first portion and the second portion are oriented at an angle of 1°-180° relative to each other.

8 . The umbilical tissue allograft of claim 7 , further comprising a third portion of cuts which is not parallel to the first portion or to the second portion.

9 . The umbilical tissue allograft of claim 3 , comprising no more than five portions of cuts, wherein each of said no more than five portions of cuts are oriented at an angle of 1°-180° relative to each of said other portions.

10 . The umbilical tissue allograft of claim 2 , wherein said cuts comprise no more than 20%, 15%, 10%, 9%, 8%, 7%, 6%, 5%, 4%, 3%, 2%, 1%, 0.5%, or 0.1% of the surface area of the allograft.

11 . The umbilical tissue allograft of claim 10 , wherein said cuts are slits.

12 . The umbilical tissue allograft of claim 1 , wherein the allograft may be expanded by at least 10%-400% along one axis by application of a force that is less than its tensile strength.

13 . The umbilical tissue allograft of claim 1 , wherein the allograft may be expanded so as to increase its surface area by at least 10%-400% by application of a force that is less than its tensile strength.

14 . The umbilical tissue allograft of claim 1 , wherein the umbilical tissue allograft is dehydrated.

15 . The umbilical tissue allograft of claim 14 , wherein the umbilical tissue allograft is lyophilized.

16 . The umbilical tissue allograft of claim 1 , contained within a sealed pouch.

17 . The umbilical tissue allograft of claim 16 , wherein said sealed pouch is deoxygenated.

18 . A method of covering a wound comprising contacting a wound with a sterile umbilical tissue allograft of claim 1 , wherein said contacting comprises expanding said sterile umbilical tissue allograft by at least 10%-400% along one axis to cover said wound.

19 . A method of treating a subject in need thereof using the umbilical tissue allograft of claim 1 , said method comprising
i) expanding said umbilical tissue allograft by at least 10%-400% along one axis, or expanding said umbilical tissue allograft so as to increase its surface area by at least 10%-400%; and ii) applying the expanded umbilical tissue allograft to the subject.

Assignees

• Mimedx Group Inc

Inventors

• Mcqueen Adam
• Levaughn Rick
• Koob Thomas J
• Massee Michelle

Classifications

• A61L27/3695 Primary

  characterised by the function or physical properties of the final product, where no specific conditions are defined to achieve this (A61L27/3687, A61L27/3691 take precedence) · CPC title

• A61L27/3604 Primary

  characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel · CPC title

• A61L2400/06

  Flowable or injectable implant compositions · CPC title

• A61L2430/34

  for soft tissue reconstruction · CPC title