pH-Triggered Therapeutical Wound Dressing

Patent metadata

Field	Value
Publication number	US-2021379241-A1
Application number	US-201917288452-A
Country	US
Kind code	A1
Filing date	Oct 23, 2019
Priority date	Oct 24, 2018
Publication date	Dec 9, 2021
Grant date	—

Abstract

The invention relates to a functional wound dressing being able to provide substances supporting the healing of a wound to the wound depending on the condition of the wound. In particular, in case of an infection which is reported to be frequently associated with poorly healing wounds, such as chronic wounds, a therapeutic substance is provided to the wound whereas in other cases no therapeutic substance is provided. The present wound dressing can be used in moist wound healing and contains a substance being able to absorb wound exudate from the wound and to provide moisture to the wound.

First claim

1 .- 14 . (canceled)

15 . A wound dressing comprising
a) a hydrogel layer able to be orientated facing towards the wound, b) a layer comprising a pH-sensitive polymer, and c) one or more compartment(s) comprising carrier containing one or more therapeutic substance(s),
wherein each compartment c) is placed in layer b), and
wherein layer b) comprises one or more recesses opposite the wound, wherein in said one or more recesses the one or more compartment(s) c) are embedded.

16 . The wound dressing according to claim 15 , wherein the hydrogel is a polyurethane-based hydrogel.

17 . The wound dressing according to claim 15 , wherein the solubility of the pH-sensitive polymer at a pH value of 4 is less than at a pH value of 8.

18 . The wound dressing according to claim 15 , wherein the solubility of the pH-sensitive polymer at 20° C. in an aqueous solution at a pH of 6 is less than 0.1 mg/min/g.

19 . The wound dressing according to claim 18 , wherein the solubility of the pH-sensitive polymer at 20° C. in an aqueous solution at a pH of 8 is more than 1 mg/min/g.

20 . The wound dressing according to claim 15 , wherein the solubility of the pH-sensitive polymer at 20° C. in an aqueous solution at a pH of 8 is more than 1 mg/min/g.

21 . The wound dressing according to claim 15 , wherein the pH-sensitive polymer is a (methyl acrylate-methyl methacrylate-methacrylic acid) copolymer.

22 . The wound dressing according to claim 15 , wherein layer b) further comprises a plasticizer.

23 . The wound dressing according to claim 15 , wherein the carrier is of the same material as the hydrogel or the pH-sensitive polymer.

24 . The wound dressing according to claim 15 , wherein the carrier is a polymer selected from polyethylene glycol, polypropylene glycol, polyethylene-polypropylene glycol copolymer, polyvinyl alcohol, polyvinylpyrrolidone, methylcellulose, hydroxypropyl methylcellulose and mixtures thereof.

25 . The wound dressing according to claim 15 , wherein the carrier is polyvinyl alcohol.

26 . The wound dressing according to claim 15 , wherein the one or more therapeutic substance(s) is an antimicrobial substance.

27 . The wound dressing according to claim 15 , wherein the one or more therapeutic substance(s) is norfloxacin, ciprofloxacin, ofloxacin, levofloxacin, sparfloxacin and/or moxifloxacin.

28 . The wound dressing according to claim 15 , wherein the carrier further contains a fluorescent dye and/or buffer substances.

29 . A method for preparing a layer comprising a pH-sensitive polymer and one or more compartment(s) comprising carrier containing one or more therapeutic substance(s), wherein each compartment is embedded in the layer comprising the pH-sensitive polymer, comprising the steps of
(i) providing a layer comprising a pH-sensitive polymer and having one or more recess(es), (ii) adding a solution comprising precursor carrier and one or more therapeutic substance(s)into the recess(es) of the layer from step (i), and (iii) hardening the carrier.

30 . A method of treating a wound comprising the step of applying to the wound a compartment comprising carrier containing one or more therapeutic substance(s), wherein said compartment is placed in or on a pH-sensitive polymer as a container for one or more therapeutic substance(s), wherein the one or more therapeutic substance(s) is provided to an infected wound.

Assignees

• Hartmann Paul Ag

Inventors

• Kettel Markus
• Jenkins Andrew Tobiass
• Wallace Laura

Classifications

• A61L15/46

  Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria · CPC title

• A61L2300/406

  Antibiotics · CPC title

• A61L15/22

  containing macromolecular materials · CPC title

• A61L26/008 Primary

  Hydrogels or hydrocolloids · CPC title

• A61L26/009 Primary

  Materials resorbable by the body · CPC title