Systems for treating pulmonary infections

Patent metadata

Field	Value
Publication number	US-2021369752-A1
Application number	US-202117175317-A
Country	US
Kind code	A1
Filing date	Feb 12, 2021
Priority date	May 21, 2012
Publication date	Dec 2, 2021
Grant date	—

Abstract

Provided herein are systems for treating a subject with a pulmonary infection, for example, a nontuberculous mycobacterial pulmonary infection, a Burkholderia pulmonary infection, a pulmonary infection associated with bronchiectasis, or a Pseudomonas pulmonary infection. The system includes a pharmaceutical formulation comprising a liposomal aminoglycoside dispersion, and the lipid component of the liposomes consist essentially of electrically neutral lipids. The system also includes a nebulizer which generates an aerosol of the pharmaceutical formulation at a rate greater than about 0.53 gram per minute. The aerosol is delivered to the subject via inhalation for the treatment of the pulmonary infection.

First claim

1 . A system for treating or providing prophylaxis against a pulmonary infection in a patient, comprising:
(a) a pharmaceutical formulation comprising a liposomal complexed aminoglycoside, wherein the formulation is an aqueous dispersion, and the lipid component of the liposome consists of electrically neutral lipids, and (b) a nebulizer which generates an aerosol of the pharmaceutical formulation at a rate greater than about 0.53 g per minute, wherein the mass median aerodynamic diameter (MMAD) of the aerosol is less than about 4.2 μm, as measured by the Anderson Cascade Impactor (ACI), or less than about 4.9 μm, as measured by the Next Generation Impactor (NGI).

2 .- 146 . (canceled)

Assignees

• Insmed Inc

Inventors

• Perkins Walter
• Malinin Vladimir
• Li Xingong
• Miller Brian
• Seidel Dominique
• Holzmann Philipp
• Schulz Harald
• Hahn Michael

Classifications

• B05B17/0646

  Vibrating plates, i.e. plates being directly subjected to the vibrations, e.g. having a piezoelectric transducer attached thereto · CPC title

• A61M15/00

  Inhalators {(drug delivery in endotracheal tubes A61M16/04)} · CPC title

• A61K31/7036 Primary

  having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins · CPC title

• A61P11/00

  Drugs for disorders of the respiratory system · CPC title

• A61P31/00

  Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics · CPC title