Functional wound dressing

Patent metadata

Field	Value
Publication number	US-2021361822-A1
Application number	US-201917055341-A
Country	US
Kind code	A1
Filing date	May 13, 2019
Priority date	May 14, 2018
Publication date	Nov 25, 2021
Grant date	—

Abstract

The invention relates to a functional wound dressing being able to detect and indicate the state of the wound, in particular with regard to infections for example caused by toxins produced by bacteria such Staphylococcus aureus and Pseudomonas aeruginosa . The present wound dressing can be used in moist wound healing and contains a substance being able to absorb wound exudate from the wound and to provide moisture to the wound.

First claim

1 . A wound dressing comprising:
a) a hydrogel selected from starch-based hydrogel, dextran-based hydrogel, alkyleneoxid-based hydrogel, cellulose-based hydrogel, pectin-based hydrogel, alginate-based hydrogel, chitosan-based hydrogel, hyaluronic acid-based hydrogel, gellan-based, polypeptide-based hydrogel, polyakyleneoixd-based hydrogel, poly(methacrylate)-based hydrogel, poly (alkyl(methacrylate)-based hydrogel, poly(ethacrylate)-based hydrogel, vinyl polymer based hydrogel, polycaprolactam- and polycaprolactone-based hydrogel, polyurethane-based hydrogel, polyurea-based hydrogel, polyurethane-polyurea-copolymer-based hydrogel and mixtures thereof; and b) a carrier containing fluorescent dye,
wherein the hydrogel comprises a buffer, wherein the buffer after being dissolved in demineralized water at 37° C. forms a buffer solution having a pH value of 6.0 to 9.0.

2 . The wound dressing according to claim 1 , wherein the hydrogel is a polyurethane-based hydrogel.

3 . The wound dressing according to claim 1 , wherein the buffer comprises 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid.

4 . The wound dressing according to claim 1 , wherein the hydrogel contains substances which at 37° C. in demineralized water exhibit a pH value of less than 6, amphiphilic substances and/or alcohol in an amount of 0 to 10 weight percent.

5 . The wound dressing according to claim 4 , wherein the substances exhibiting a pH value of less than 6 in demineralized water at 37° C. comprise organic acids, enolic compounds, fatty acids and amino acids.

6 . The wound dressing according to claim 4 , wherein amphiphilic substances comprise polyethylene glycol p-(1,1,3,3-tetramethylbutyl)-phenyl ether (Triton) and/or polyetheramine (Jeffamine).

7 . The wound dressing according to claim 4 , wherein the alcohol comprises diethylene glycol, dipropylene glycol and glycerol.

8 . The wound dressing according to claim 1 , wherein the carrier is a liposome.

9 . The wound dressing according to claim 8 , wherein the liposome comprises:
a) at least one of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine, 1,2-distearyl-sn-glycero-3-phosphocholine, 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine, 1,2-distearyl-sn-glycero-3-phosphoethanolamine and 10,12-tricosadiynoic acid; and b) a sterol.

10 . The wound dressing according to claim 1 , wherein the fluorescent dye belongs to the group of xanthenes bearing at least one hydroxy group at the xanthene skeleton.

11 . The wound dressing according to claim 10 , wherein the fluorescent dye is fluorescein or carboxy fluorescein.

Assignees

• Hartmann Paul Ag
• Univ Bath

Inventors

• Kettel Markus
• Jenkins Andrew Tobias
• Thet Naing Tun

Classifications

• A61L2300/442

  Colorants, dyes · CPC title

• A61L15/56 Primary

  Wetness-indicators or colourants · CPC title

• A61L2300/802

  Additives, excipients, e.g. cyclodextrins, fatty acids, surfactants · CPC title

• A61L2300/214

  Amino acids · CPC title

• A61L15/60

  Liquid-swellable gel-forming materials, e.g. super-absorbents · CPC title