Mucoadhesive Patch and Uses Thereof

Patent metadata

Field	Value
Publication number	US-2021353529-A1
Application number	US-202117321370-A
Country	US
Kind code	A1
Filing date	May 14, 2021
Priority date	May 14, 2020
Publication date	Nov 18, 2021
Grant date	—

Abstract

The present invention provides a mucoadhesive patch for attachment to a mucosal surface in a patient, the patch comprising a fibrous polymeric mat substrate and a plurality of polymeric flock particles that are attached to the substrate.

First claim

1 . A mucoadhesive patch for attachment to a mucosal surface in a patient, the patch comprising a fibrous polymeric mat substrate and a plurality of polymeric flock particles that are attached to the substrate.

2 . The mucoadhesive patch of claim 1 , the fibers of the polymeric mat substrate comprising at least one of polycaprolactone (PCL), poly(lactic-co-glycolic acid (PLGA) and polymethylmethacrylate (PMMA).

3 . The mucoadhesive patch of claim 1 , wherein the fibers of the polymeric mat substrate comprise PCL.

4 . The mucoadhesive patch of claim 3 , the patch incorporating a drug to be delivered to a region of the mucosal surface.

5 . The mucoadhesive patch of claim 1 , wherein the patch exhibits sustained release of the drug over a period of at least 28 days.

6 . The mucoadhesive patch of claim 4 , wherein the drug is an anti-inflammatory drug.

7 . (canceled)

8 . (canceled)

9 . (canceled)

10 . (canceled)

11 . The mucoadhesive patch of claim 1 , wherein a drug to be delivered to a region of the mucosal surface can be included in the monomer solution prior to the electrospinning

12 . The mucoadhesive patch of claim 11 , wherein the flock particles were drawn to the substrate using an applied potential.

13 . The mucoadhesive patch of claim 12 , wherein a magnitude of the applied potential determines a concentration of the flock particles on the substrate.

14 . The mucoadhesive patch of claim 1 , wherein the flock particles are attached to the substrate by covalent crosslinking.

15 . (canceled)

16 . The mucoadhesive patch of claim 1 , wherein a monomer in the monomer solution is identical with a monomer of which the polymeric flock particles are formed.

17 . The mucoadhesive patch of claim 1 , wherein the flock particles comprise polyethylene glycol diacrylate (PEGDA).

18 . (canceled)

19 . (canceled)

20 . The mucoadhesive patch of claim 1 , the patch being capable of closing an esophageal or laryngotracheal wound in a patient.

21 . (canceled)

22 . A method of making a mucoadhesive patch of claim 1 for attachment to a mucosal surface in a patient, the method comprising:
dissolving a substrate monomer in one or more organic solvents to form a first solution of a first monomer;
drawing the first monomer solution into a syringe;
applying a first electrical potential as part of an electrospinning technique to form substrate fibers;
forming the substrate fibers into a fibrous polymeric mat substrate;
immersing the fibrous polymeric mat substrate in a second solution of a second monomer, the second solution comprising a photochemical initiator;
removing excess second monomer solution by centrifugation;
attaching polymeric flock particles to the substrate using a second applied electrical potential;
exposing the substrate to ultraviolet light to permanently attach the polymeric flock particles to the substrate by crosslinking; and
soaking the substrate in water to remove unreacted monomers and initiator.

23 . The method of claim 22 , the first solution further comprising a first drug to be delivered to a region of the mucosal surface.

24 . The method of claim 23 , wherein the first drug is a corticosteroid.

25 . The method of claim 24 , wherein the first drug is dexamethasone.

26 . (canceled)

27 . (canceled)

28 . (canceled)

29 . (canceled)

30 . (canceled)

31 . (canceled)

32 . (canceled)

33 . (canceled)

34 . (canceled)

35 . A method of treating a disease or condition in a subject in need thereof, comprising administering to a mucosal surface of the subject, an effective amount of the mucoadhesive patch of claim 1 .

36 . The method of claim 35 , wherein the patch is administered to an esophageal or laryngotracheal mucosal surface.

37 . The method of claim 35 , wherein the patch is applied to a wound.

38 . (canceled)

39 . (canceled)

40 . (canceled)

Assignees

• Univ Texas

Inventors

• Miar Solaleh
• Dion Gregory Robert
• Ong Joo Leng
• Guda Teja

Classifications

• D01F6/16

  from polymers of unsaturated carboxylic acids or unsaturated organic esters, e.g. polyacrylic esters, polyvinyl acetate · CPC title

• D06M10/10

  Macromolecular compounds · CPC title

• D01F6/625

  derived from hydroxy-carboxylic acids, e.g. lactones · CPC title

• D01D5/0084

  Coating by electro-spinning, i.e. the electro-spun fibres are not removed from the collecting device but remain integral with it, e.g. coating of prostheses · CPC title

• D06M14/32

  Polyesters · CPC title