Modular synthetic tissue-graft scaffold

Patent metadata

Field	Value
Publication number	US-2021322632-A1
Application number	US-201917263873-A
Country	US
Kind code	A1
Filing date	Jul 26, 2019
Priority date	Jul 27, 2018
Publication date	Oct 21, 2021
Grant date	—

Abstract

A modular synthetic tissue-graft scaffold ( 10 ) includes one or more nominally identical scaffold cages ( 12 ) configured to facilitate regrowth of tissue of an organism in and around the scaffold cages. Each scaffold cage comprises a volumetric enclosure ( 18 ) bounded by a perforated wall structure ( 40 ). A recess ( 24 ) formed at one end of the volumetric enclosure defines an inner stepped coupling surface. An annular raised portion ( 26 ) positioned at the other end of the volumetric enclosure forms an outwardly projecting stepped seating surface sized to form a complementary matable surface to the inner stepped coupling surface for whenever an inner stepped coupling surface of another one of the cages is placed on the outer stepped seating surface of the scaffold cage. Corridors ( 46 ) extending through the perforated wall structure and communicating with passageways ( 54 ) within the volumetric enclosure enable migration of material within and out of the scaffold cage.

First claim

1 . In a modular, synthetic tissue-graft scaffold including a set of one or more nominally identical scaffold cages that are configured to facilitate regrowth of tissue of an organism in and around the scaffold cages, each scaffold cage in the set comprising:
a volumetric enclosure bounded by a perforated wall structure and having interior and exterior surfaces and first and second opposite ends, the volumetric enclosure defining a central longitudinal axis that extends through the first and second opposite ends, the interior surface defining a boundary of an interior chamber of the volumetric enclosure, and the interior and exterior surfaces defining between them a thickness of the perforated wall structure; a perforated platform set within the volumetric enclosure and in transverse relation to the central longitudinal axis forms a recess at the first end of the volumetric enclosure, the recess defining an inner stepped coupling surface bounded by the interior surface of the perforated wall structure, the perforated platform providing a passageway within the interior chamber of the volumetric enclosure between its first and second opposite ends; an annular raised portion positioned at the second end of the volumetric enclosure and forming an outwardly projecting stepped seating surface including a first portion that is transverse to the central longitudinal axis and a second portion that is transverse to the first portion, and the outwardly projecting stepped seating surface sized to form a complementary matable surface to the inner stepped coupling surface whenever an inner stepped coupling surface of another one of the cages in the set is placed on the outer stepped seating surface of the scaffold cage; and corridors extending through the thickness of the perforated wall structure and communicating with the passageway within the interior chamber of the volumetric enclosure to enable migration of material within and out of the scaffold cage.

2 . The modular scaffold of claim 1 , in which the set includes an array of multiple nominally identical scaffold cages in the form of a scaffold cage sheet, the multiple scaffold cages oriented such that their associated central longitudinal axes are in generally parallel alignment and the exterior surfaces of mutually adjacent cages are fused to each other and thereby form a fused perforated wall structure, the fused perforated wall structure having a thickness through which spatially aligned corridors extend to allow migration of material between the interior chambers of the mutually adjacent scaffold cages.

3 . The modular scaffold of claim 2 , in which the scaffold cages forming the cage sheet include scaffold cages having annular raised portions positioned at first opposite ends and perforated platforms set to form recesses at second opposite ends.

4 . The modular scaffold of claim 1 , in which the modular scaffold is made of β-tricalcium phosphate.

5 . The modular scaffold of claim 1 , in which the modular scaffold is made of α-tricalcium phosphate, dicalcium phosphate, calcium carbonate, zirconium oxide or aluminum oxide.

6 . The modular scaffold of claim 1 , in which the modular scaffold is manufactured using a lithography-based three-dimensional printing technology.

7 . The modular scaffold of claim 1 , in which the modular scaffold is manufactured using a mold-based, a sculpting-based, or a subtractive manufacturing method.

8 . The modular scaffold of claim 1 , in which the inner stepped coupling surface is generally shaped as a circle, ellipse, or polygon.

9 . The modular scaffold of claim 1 , in which the annular raised portion is generally shaped as a circle, ellipse, or polygon.

10 . The modular scaffold of claim 1 , in which the perforated platform constitutes a first perforated platform, and further comprising a second perforated platform, the second perforated platform set transverse to the central longitudinal axis of the volumetric enclosure of the cage and proximal to the second end of the volumetric enclosure relative to the first perforated platform to define a platform pair, the platform pair providing a passageway within the interior chamber of the volumetric enclosure between the first and second ends.

11 . The modular scaffold of claim 1 , in which the exterior surface of the perforated wall structure constitutes one or more wall aspects, and the perforated wall structure includes no corridor extending through its thickness at one or more of the wall aspects.

12 . The modular scaffold of claim 1 , in which the passageway within the interior chamber terminates at and therefore does not extend through one of the first and second opposite ends of the volumetric enclosure.

13 . The modular scaffold of claim 1 , further comprising a tissue-graft material inserted into the interior chamber of the volumetric enclosure.

Assignees

• Univ Oregon Health & Science

Inventors

• Bertassoni Luiz E
• Athirasala Avathamsa
• Tahayeri Anthony

Classifications

• A61F2002/3093

  for promoting ingrowth of bone tissue · CPC title

• A61F2002/30604

  modular · CPC title

• A61F2002/30263

  cubical · CPC title

• A61F2/2846

  Support means for bone substitute or for bone graft implants, e.g. membranes or plates for covering bone defects (nets or sleeves applied to surface of endoprostheses A61F2/30907; bone plates A61B17/80; bone regeneration in dental surgery A61C8/0006) · CPC title

• A61L27/54

  Biologically active materials, e.g. therapeutic substances {(A61L27/227 takes precedence)} · CPC title