Respiratory treatment system including physiological sensors

Patent metadata

Field	Value
Publication number	US-2021315482-A1
Application number	US-202117155671-A
Country	US
Kind code	A1
Filing date	Jan 22, 2021
Priority date	Dec 19, 2011
Publication date	Oct 14, 2021
Grant date	—

Abstract

An apparatus assesses a condition of a patient. The apparatus may contain a patient interface for communicating a treatment generated by a respiratory treatment apparatus to the respiratory system of a patient. The apparatus may also include a sensing module containing one or more electrochemical sensors to sense chemicals in exhaled breath in real time, or over an extended period of time. The apparatus may also include one or more collectors to accumulate a breath condensate over an extended period of time. The sample collectors may contain an absorbent material, and may also be adapted for replacement within a sensing module. The absorbent material may also include a preservative for preserving a chemical component of the breath, such as an analyte of the exhaled breath. The technology may provide treatment recommendations based on the detected condition of the breath condensate or the chemical components thereof

First claim

1 . An apparatus for assessing a condition of a patient comprising:
a patient interface, the patient interface configured to communicate a pressure treatment generated by a respiratory treatment apparatus to the respiratory system of the patient, the patient interface comprising a cushion configured to provide a pressure seal for the pressure treatment, the cushion being formed of a material; and a module being removably embedded within the material of the cushion of the patient interface, and including one or more collectors configured to accumulate at least one of: exhaled breath that is exhaled to the patient interface; saliva that is in contact with the patient interface; and mucus that is in contact with the patient interface, wherein a port within the cushion to the module (a) is proximate to a patient's mouth so as to be exposed to patient exhalation gases and (b) provides the collector access to the exhaled breath.

2 . The apparatus of claim 1 wherein the module comprises a plurality of sample collectors.

3 . The apparatus of claim 1 wherein the one or more collectors are adapted for replacement within the module.

4 . The apparatus of claim 1 wherein at least one collector comprises an absorbent material.

5 . The apparatus of claim 4 wherein the absorbent material includes a preservative for preserving an analyte collected from the exhaled breath.

6 . The apparatus of claim 1 wherein the module further comprises an electrochemical sensor, the electrochemical sensor configured to sense a chemical in breath condensate accumulated by at least one collector.

7 . The apparatus of claim 6 wherein the module comprises a plurality of electrochemical sensors.

8 . The apparatus of claim 1 further comprising:
said respiratory treatment apparatus, the respiratory treatment apparatus including a flow generator and a controller, including at least one processor, to control the flow generator to generate the pressure treatment to the patient interface, and
an electrochemical sensor, the electrochemical sensor configured to sense a chemical in breath condensate accumulated by at least one collector and generate a signal indicative of the chemical,
wherein the controller is coupled with the sensor, and
the processor is configured to store a measure derived from the signal.

9 . The apparatus of claim 8 wherein the sensor is integrated with a housing of the flow generator.

10 . The apparatus of claim 8 wherein the processor is configured to synchronize an activation of the electrochemical sensor with an expiratory phase of a detected breath cycle.

11 . The apparatus of claim 8 wherein the processor is configured to activate the electrochemical sensor after a set period of time.

12 . The apparatus of claim 11 wherein the set period of time comprises one of the group consisting of: a number of treatment sessions with the respiratory treatment apparatus; a timed period of use of the respiratory treatment apparatus; and a breath cycle count.

13 . The apparatus of claim 8 wherein at least one collector of the module comprises a variable aperture controlled by the processor.

14 . The apparatus of claim 13 wherein the processor is configured to synchronize opening of the variable aperture with an expiratory phase of a detected breath cycle.

15 . The apparatus of claim 13 wherein the processor is configured to open the variable aperture for a set period of time.

16 . The apparatus of claim 15 wherein the set period of time comprises one of the group consisting of: a breath cycle count; a timed period of use of the respiratory treatment apparatus; and a number of treatment sessions with the respiratory treatment apparatus.

17 . The apparatus of claim 8 wherein the processor is configured to compare the measure derived from the signal and a threshold value.

18 . The apparatus of claim 17 wherein the processor is configured to generate a warning based on the comparison.

19 . The apparatus of claim 8 wherein the processor detects a quantity of an analyte from the exhaled breath.

20 . The apparatus of claim 1 wherein the module comprises one or more of a peroxide sensor, a nitrous oxide sensor, an acetone sensor, a carbon dioxide sensor, a pH sensor, a glucose sensor, and a lactate sensor.

21 . The apparatus of claim 1 , wherein at least one collector is configured to collect exhaled breath.

22 . The apparatus of claim 1 , wherein at least one collector is configured to accumulate saliva that is in contact with the patient interface.

23 . The apparatus of claim 22 wherein the module further comprises an electrochemical sensor, the electrochemical sensor configured to sense a chemical in saliva accumulated by the at least one collector.

24 . The apparatus of claim 1 , wherein at least one collector is configured to accumulate mucus that is in contact with the patient interface.

25 . The apparatus of claim 24 wherein the module further comprises an electrochemical sensor, the electrochemical sensor configured to sense a chemical in mucus accumulated by the at least one collector.

26 . The apparatus of claim 24 wherein the patient interface comprises a nasal cannula and the module comprises at least one prong of the nasal cannula to contact a mucosa of the patient.

27 . The apparatus of claim 8 wherein the electrochemical sensor is further configured to detect a quantity of an analyte from saliva.

28 . The apparatus of claim 8 wherein the electrochemical sensor is further configured to detect a quantity of an analyte from mucus.

29 . The apparatus of claim 27 wherein the analyte is one or more of NH 4 + , acetate, NH 3 + , and Ca + .

30 . An apparatus for assessing a condition of a patient comprising:
a flow generator, adapted to couple with a patient interface configured to direct a flow of breathable gas, the flow generator configured to generate a flow of breathable gas to the patient interface, a controller, including at least one processor, the controller being configured to control a pressure treatment protocol with the flow generator; and a sensing module, including at least one electrochemical sensor, at least a portion of the sensing module being removably embedded within the patient interface, the portion of the sensing module embedded within the patient interface including a collector configured to accumulate exhaled breath condensate that is exhaled to the patient interface, the electrochemical sensor configured to sense a chemical accumulated by the collector and generate a signal indicative of the chemical of the collector.

31 . The apparatus of claim 30 wherein the controller is coupled with the sensor and the processor is configured to store a measure derived from the signal.

32 . The apparatus of claim 30 wherein the sensing module comprises a plurality of sample collectors.

33 . The apparatus of claim 30 wherein the collector is adapted for replacement within the sensing module.

34 . The apparatus of claim 33 wherein the collector comprises an absorbent material.

35 . The apparatus of claim 34 wherein the absorbent material includes a preservative for preserving an analyte collected from the exhaled breath.

36 . T

Assignees

• ResMed Pty Ltd

Inventors

• Schindhelm Klaus Henry
• Farrugia Steven Paul
• Pani Michael Aleksander
• Green Paul Anthony

Classifications

• A61M16/0683

  Holding devices therefor · CPC title

• A61M2230/43

  Composition of exhalation · CPC title

• A61M2230/432

  partial CO2 pressure (P-CO2) · CPC title

• A61M16/0633

  with forehead support · CPC title

• A61M16/085

  Gas sampling · CPC title