Systems And Methods For Noise Removal In An Optical Measurement System

Patent metadata

Field	Value
Publication number	US-2021290171-A1
Application number	US-202117202681-A
Country	US
Kind code	A1
Filing date	Mar 16, 2021
Priority date	Mar 20, 2020
Publication date	Sep 23, 2021
Grant date	—

Abstract

An illustrative optical measurement system includes a light source configured to emit light directed at a target within a user, the target covered by a superficial layer, and an array of photodetectors configured to detect photons of the light after the light is scattered. The system further includes a processor configured to record, during a first and a second time period, a first and a second set of timestamp symbols, respectively, based on a first and a second subset of the array of photodetectors detecting a first subset of the photons that are scattered by the superficial layer and a second subset of the photons that are scattered by the target and the superficial layer, respectively. The processor is further configured to filter, based on the first set of histogram data, the second set of histogram data, and determine, based on the filtering, histogram data corresponding to the target.

First claim

1 . An optical measurement system comprising:
a light source configured to emit light directed at a target within a user, the target being covered by a superficial layer; an array of photodetectors configured to detect photons of the light after the light is scattered; an array of time-to-digital converters (TDCs) configured to:
record, during a first time period, a first set of timestamp symbols based on a first subset of the array of photodetectors detecting a first subset of the photons that are scattered by the superficial layer; and
record, during a second time period, a second set of timestamp symbols based on a second subset of the array of photodetectors detecting a second subset of the photons that are scattered by the target and the superficial layer; and
a processing unit configured to:
determine, based on the first set of timestamp symbols, a first set of histogram data corresponding to the superficial layer;
determine, based on the second set of timestamp symbols, a second set of histogram data corresponding to both the target and the superficial layer;
filter, based on the first set of histogram data, the second set of histogram data; and
determine, based on the filtering, histogram data corresponding to the target.

2 . The optical measurement system of claim 1 , wherein:
the target comprises a region of a brain of the user; and the superficial layer comprises one or more of a scalp, a skull, cerebrospinal fluid, and a blood brain barrier of the user.

3 . The optical measurement system of claim 1 , wherein the filtering the second set of histogram data comprises using a machine learning algorithm.

4 . The optical measurement system of claim 3 , wherein the machine learning algorithm comprises a supervised machine learning model trained using data corresponding to known behavioral choices.

5 . The optical measurement system of claim 4 , wherein the processing unit is further configured to determine, based on the histogram data corresponding to the target, a behavioral prediction of the user.

6 . The optical measurement system of claim 5 , wherein the determining the behavioral prediction of the user comprises further filtering the histogram data corresponding to the target using the machine learning algorithm.

7 . The optical measurement system of claim 1 , wherein the filtering the second set of histogram data comprises using independent component analysis.

8 . A wearable system for use by a user comprising:
a head-mountable component configured to be attached to a head of the user, the head-mountable component comprising an array of photodetectors configured to detect photons from a light pulse after the light pulse reflects off at least one of a target within the head and a superficial layer covering the target; an array of time-to-digital converters (TDCs) configured to:
record, during a first time period, a first set of timestamp symbols based on a first subset of the array of photodetectors detecting a first subset of the photons that are scattered by the superficial layer; and
record, during a second time period, a second set of timestamp symbols based on a second subset of the array of photodetectors detecting a second subset of the photons that are scattered by the target and the superficial layer; and
a processing unit configured to:
determine, based on the first set of timestamp symbols, a first set of histogram data corresponding to the superficial layer;
determine, based on the second set of timestamp symbols, a second set of histogram data corresponding to both the target and the superficial layer;
filter, based on the first set of histogram data, the second set of histogram data; and
determine, based on the filtering, histogram data corresponding to the target.

9 . The wearable system of claim 8 , wherein:
the target comprises a region of a brain of the user; and the superficial layer comprises one or more of a scalp, a skull, cerebrospinal fluid, and a blood brain barrier of the user.

10 . The wearable system of claim 8 , wherein the filtering the second set of histogram data comprises using a machine learning algorithm.

11 . The wearable system of claim 10 , wherein the machine learning algorithm comprises a supervised machine learning model trained using data corresponding to known behavioral choices.

12 . The wearable system of claim 11 , wherein the processing unit is further configured to determine, based on the histogram data corresponding to the target, a behavioral prediction of the user.

13 . The wearable system of claim 12 , wherein the determining the behavioral prediction of the user comprises further filtering the histogram data corresponding to the target using the machine learning algorithm.

14 . The wearable system of claim 8 , wherein the filtering the second set of histogram data comprises using independent component analysis.

15 . A system comprising:
a memory storing instructions; a processor communicatively coupled to the memory and configured to execute the instructions to:
access a first set of timestamp symbols based on a first subset of an array of photodetectors detecting a first subset of photons that are scattered by a superficial layer that covers a target within a user, the first set of timestamp symbols representing times within a first time period;
determine, based on the first set of timestamp symbols, a first set of histogram data corresponding to the superficial layer;
access a second set of timestamp symbols based on a second subset of the array of photodetectors detecting a second subset of the photons that are scattered by the target and the superficial layer, the second set of timestamp symbols representing times within a second time period;
determine, based on the second set of timestamp symbols, a second set of histogram data corresponding to both the target and the superficial layer;
filter, based on the first set of histogram data, the second set of histogram data; and
determine, based on the filtering, histogram data corresponding to the target.

16 . The system of claim 15 , wherein:
the target comprises a region of a brain of the user; and the superficial layer comprises one or more of a scalp, a skull, cerebrospinal fluid, and a blood brain barrier of the user.

17 . The system of claim 15 , wherein the filtering the second set of histogram data comprises using a machine learning algorithm.

18 . The system of claim 17 , wherein the machine learning algorithm comprises a supervised machine learning model trained using data corresponding to known behavioral choices.

19 . The system of claim 18 , wherein the processor is further configured to execute the instructions to determine, based on the histogram data corresponding to the target, a behavioral prediction of the user.

20 . The system of claim 19 , wherein the determining the behavioral prediction of the user comprises further filtering the histogram data corresponding to the target using the machine learning algorithm.

21 . The system of claim 15 , wherein the filtering the second set of histogram data comprises using independent component analysis.

22 - 28 . (canceled)

Assignees

• Hi Llc

Inventors

• Katnani Husam
• Ojeda Alejandro
• Perdue Katherine

Classifications

• A61B5/6803

  Head-worn items, e.g. helmets, masks, headphones or goggles · CPC title

• A61B2576/026

  for the brain · CPC title

• A61B5/0059

  using light, e.g. diagnosis by transillumination, diascopy, fluorescence (photoacoustic A61B5/0093; optical measurement of heart rate A61B5/02416; optical measurement of blood flow A61B5/0261; optical measurement of analytes A61B5/1455) · CPC title

• A61B5/0073

  by tomography, i.e. reconstruction of 3D images from 2D projections (A61B5/0066 takes precedence) · CPC title

• A61B5/0075

  by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy (A61B5/0071 takes precedence) · CPC title