A series of pyrrole derivatives and their preparation method and therapeutic use
US-2024327423-A1 · Oct 3, 2024 · US
US2021284656A9 · US · A9
| Field | Value |
|---|---|
| Publication number | US-2021284656-A9 |
| Application number | US-201916264194-A |
| Country | US |
| Kind code | A9 |
| Filing date | Jan 31, 2019 |
| Priority date | Aug 14, 2003 |
| Publication date | Sep 16, 2021 |
| Grant date | — |
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The invention includes methods of using compounds of Formula I as type I receptor tyrosine kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
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What is claimed is: 1 . A method of treating gliomas, cancer of the ovary, bladder cancer, cancer of the esophagus, cancer of the uterus, prostate cancer, kidney cancer, skin cancer, cancer of the pancreas, leukemias, or lymphomas comprising administering a therapeutically effective amount of a compound selected from the group consisting of: 2 . The method of claim 1 , wherein the compound is: 3 . A method of inhibiting the activity of ErbB2 comprising administering a compound selected from the group consisting of: 4 . The method of claim 3 , wherein the compound is: 5 . A method of treating diseases or medical conditions mediated by type I receptor tyrosine kinases which comprises administering to a warm-blooded animal an effective amount of a compound selected from the group consisting of: 6 . The method of claim 5 , wherein the type I receptor tyrosine kinase is ErbB2. 7 . The method of claim 5 , wherein the compound is: 8 . The method of claim 6 , wherein the compound is:
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linked by a chain containing hetero atoms as chain links · CPC title
linked by a chain containing hetero atoms as chain links · CPC title
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