Drug delivery device comprising an adjustment member

Patent metadata

Field	Value
Publication number	US-2021283340-A1
Application number	US-201716316309-A
Country	US
Kind code	A1
Filing date	Jul 7, 2017
Priority date	Jul 8, 2016
Publication date	Sep 16, 2021
Grant date	—

Abstract

The present invention relates to a drug delivery device that houses a piston equipped cartridge and a drive mechanism comprising a piston rod (170) configured for axially moving the piston in a distal direction. An adjustment member (150) connects to the member (150) comprises a first contour system (175) defining a plurality of steps (175′, 175″, 175′″) being circumferentially disposed and arranged axially offset from one another. The other of the piston rod (170) and the adjustment member (150) comprises at least one radially disposed protrusion (155). For eliminating an axial clearance between the piston rod (170) and the piston of the cartridge the at least one radially disposed protrusion (155) axially engages a selective one of said plurality of steps (175′, 175″, 175′″) so that the relative rotational position between the piston rod (170) and the adjustment member (150) is decisive for the axial position of the adjustment member (150) relative to the piston rod (170).

First claim

1 . A drug delivery device for dispensing one or more doses of a medicament, comprising:
a medicament cartridge, wherein the cartridge comprises a body extending along an axis and defining a distal end and a proximal end, and a piston arranged slideably relative to the cartridge body, a drive mechanism comprising a piston rod configured for axially moving the piston in the distal direction, wherein the piston rod connects to an adjustment member located at least partially between the piston rod and a proximal face of the piston, wherein the adjustment member is configured to abut or cooperate with the proximal face of the piston to reduce an axial clearance between the piston rod and the proximal face of the piston, wherein one of the piston rod and the adjustment member comprises a first contour system comprising a plurality of axially facing steps being circumferentially disposed and arranged axially offset from one another, wherein the other of the piston rod and the adjustment member comprises at least one radially disposed protrusion; and wherein said at least one radially disposed protrusion axially engages a selective one of said plurality of axially facing steps of the first contour system so that the relative rotational position between the piston rod and the adjustment member determines the axial position of the adjustment member relative to the piston rod when the adjustment member is positioned in full axial engagement with the piston rod.

2 . The drug delivery device as defined in claim 1 , wherein said at least one radially disposed protrusion defines a plurality of radially disposed protrusions.

3 . The drug delivery device as defined in claim 2 , wherein the plurality of radially disposed protrusions define a second contour system wherein the plurality of radially disposed protrusions are arranged axially offset to one another to cooperate and engage with respective axially facing steps of the first contour system.

4 . The drug delivery device as defined in claim 1 , wherein each said plurality of axially facing steps defines a bottom surface of a respective axially extending channel.

5 . The drug delivery device as defined in claim 1 , wherein the piston rod comprises a first rotational block geometry and the adjustment member comprises a second rotational block geometry to cooperate with the first rotational block geometry to prevent the said at least one radially disposed protrusion from disengaging the selected one of said plurality of axially facing steps of the first contour system when the adjustment member is situated in full axial engagement with the piston rod.

6 . The drug delivery device as defined in claim 1 , wherein each of the at least one radially disposed protrusion defines an abutment surface having a shape mating with an abutment surface defined by each of the plurality of axially facing steps.

7 . The drug delivery device as defined in claim 1 , wherein said plurality of axially facing steps each comprises a surface having a surface normal oriented substantially parallel with the axis.

8 . The drug delivery device as defined in claim 1 , wherein, when the at least one radially disposed protrusion engages a respective one of said series of axially facing steps of the first contour system, a press-fit engagement between the piston rod and the adjustment member is provided.

9 . The drug delivery device as defined in claim 1 , wherein one of the piston rod and the adjustment member defines an axially extending shaft member being received in an axial bore of the other of the piston rod and the adjustment member.

10 . The drug delivery device as defined in claim 9 , wherein said axial bore is defined by an end portion having walls at least partly circumscribing the axial bore, and wherein the walls circumscribing the axial bore provides radial resiliency retaining said axially extending shaft member.

11 . The drug delivery device as defined in claim 1 , wherein the adjustment member defines said at least one radially disposed protrusion and wherein the adjustment member defines a first end and an opposite second end.

12 . The drug delivery device as defined in claim 11 , wherein the adjustment member is configured for being inserted between the piston and the piston rod selectively with the first end of the adjustment member facing the piston rod or with the second end of the adjustment member facing the piston rod.

13 . The drug delivery device as defined in claim 12 , wherein respective ones of said at least one radially disposed protrusion are arranged at an axial distance from the first end of the adjustment member thereby defining a first set of respective distances and wherein respective ones of said at least one radially disposed protrusion are arranged at an axial distance from the second end of the adjustment member thereby defining a second set of respective distances and wherein the first set of respective distances differs from the second set of respective distances.

14 . The drug delivery device as defined in claim 13 , wherein a piston washer is arranged between the adjustment member and the piston and wherein the first end of the adjustment member and/or the second end of the adjustment member is formed with a rotation symmetrical portion configured for mating with a bearing surface of the piston washer.

15 . The drug delivery device as defined in claim 1 , wherein a piston washer is arranged between the adjustment member and the piston.

Assignees

• Novo Nordisk As

Inventors

• Bengtsson Henrik
• Spork Emil Gram

Classifications

• A61M5/31515

  Connection of piston with piston rod · CPC title

• A61M5/3146 Primary

  Priming, e.g. purging, reducing backlash or clearance · CPC title

• A61M2005/2407

  from the rear · CPC title

• A61M5/24

  Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic {(ampoules or carpules A61J1/06)} · CPC title

• F04B53/008

  Spacing or clearance between cylinder and piston · CPC title