Method for producing functional substance

Patent metadata

Field	Value
Publication number	US-2021222206-A1
Application number	US-202117153702-A
Country	US
Kind code	A1
Filing date	Jan 20, 2021
Priority date	Jan 21, 2020
Publication date	Jul 22, 2021
Grant date	—

Abstract

An object of the present invention is to a method for producing a functional substance utilizing a reaction requiring hydrogen, which production method is safe and efficient; and this object is achieved by a method for producing a functional substance utilizing a reaction requiring hydrogen, the method comprising: supplying the hydrogen by culturing of a hydrogen-producing microorganism.

First claim

What is claimed is:

1 . A method for producing a functional substance utilizing a reaction requiring hydrogen, the method comprising:
supplying the hydrogen by culturing of a hydrogen-producing microorganism.

2 . The method according to claim 1 , wherein the reaction requiring hydrogen is a bioconversion reaction.

3 . The method according to claim 1 , wherein the functional substance is a functional metabolite produced by metabolism in an intestinal bacterium.

4 . The method according to claim 3 , wherein the metabolism in the intestinal bacterium is a dehydroxylation reaction.

5 . The method according to claim 3 , wherein the functional metabolite is an equol compound.

6 . The method according to claim 3 , wherein the functional metabolite is a urolithin compound.

7 . The method according to claim 5 , wherein the equol compound is equol or 5-hydroxyequol.

8 . The method according to claim 6 , wherein the urolithin compound is urolithin A, urolithin B, urolithin C, urolithin D, urolithin E, urolithin M3, urolithin M4, urolithin M5, urolithin M6, isourolithin A, or 6H-dibenzo[b,d]pyran-6-one.

9 . The method according to claim 1 , wherein the hydrogen-producing microorganism is one or more bacteria selected from the group consisting of bacteria belonging to the genus Clostridium , bacteria belonging to the genus Enterobacter , bacteria belonging to the genus Rhodopseudomonas , bacteria belonging to the genus Achromobacter , bacteria belonging to the genus Arthrobacter , bacteria belonging to the genus Serratia , bacteria belonging to the genus Alcaligenes , bacteria belonging to the genus Ruminococcus , bacteria belonging to the genus Blautia , and bacteria belonging to the genus Sarcina.

10 . The method according to claim 1 , wherein the hydrogen-producing microorganism is one or more bacteria selected from the group consisting of bacteria belonging to Clostridium asparagiforme , bacteria belonging to Clostridium bolteae , bacteria belonging to Clostridium butyricum , bacteria belonging to Clostridium citroniae , bacteria belonging to Enterobater aerogenes , bacteria belonging to Blautia producta , bacteria belonging to Blautia coccoides , bacteria belonging to Blautia schinkii , and bacteria belonging to Rhodopseudomonas palustris.

11 . The method according to claim 1 , wherein, in the hydrogen-supplying step, the hydrogen-producing microorganism coexists with a microorganism which produces the functional substance.

12 . The method according to claim 11 , wherein the microorganism which produces the functional substance does not substantially produce hydrogen.

13 . The method according to claim 1 , wherein, in the hydrogen-supplying step,
the microorganism which produces the functional substance from a precursor of the functional substance is the hydrogen-producing microorganism; and a microorganism which produces the precursor is a microorganism which produces the precursor from a raw material of the precursor using hydrogen supplied by the hydrogen-producing microorganism.

14 . The method according to claim 13 , wherein the microorganism which produces the precursor is a microorganism which does not substantially produce hydrogen.

15 . A method for producing a functional food, the method comprising:
producing a functional substance utilizing a reaction requiring hydrogen, the hydrogen being supplied by culturing of a hydrogen-producing microorganism; and mixing the functional substance with a raw material of a food.

16 . A method for producing a food additive, the method comprising:
producing a functional substance utilizing a reaction requiring hydrogen, the hydrogen being supplied by culturing of a hydrogen-producing microorganism; and mixing the functional substance with a raw material of a food additive.

Assignees

• Daicel Corp

Inventors

• Yamamoto Yuhei
• Yamamoto Hiroaki

Classifications

• C12P39/00

  Processes involving microorganisms of different genera in the same process, simultaneously · CPC title

• A23L33/135

  Bacteria or derivatives thereof, e.g. probiotics · CPC title

• C12P3/00 Primary

  Preparation of elements or inorganic compounds except carbon dioxide {(recovery of carbon dioxides as by-products C12F3/02)} · CPC title

• C12N1/205

  Bacterial isolates · CPC title

• C12P17/06

  containing a six-membered hetero ring, e.g. fluorescein · CPC title