Electroporation system and method

Patent metadata

Field	Value
Publication number	US-2021161582-A1
Application number	US-202017247198-A
Country	US
Kind code	A1
Filing date	Dec 3, 2020
Priority date	Dec 3, 2019
Publication date	Jun 3, 2021
Grant date	—

Abstract

Disclosed herein is an electroporation system including a catheter shaft, at least one electrode coupled to the catheter shaft at a distal end thereof, and an electroporation generator coupled in communication with the at least one electrode. The electroporation generator configured to supply a biphasic pulse signal to the at least one electrode. The biphasic pulse signal includes a first phase having a first polarity and a first pulse duration, and a second phase having a second polarity opposite to the first polarity, and a second pulse duration. Each of the first phase and second phase has a voltage amplitude of at least 500 volts and a pulse duration of less than 20 microseconds. The second phase is generated at a non-zero interval following the first phase.

First claim

1 . An electroporation system comprising:
a catheter shaft; at least one electrode coupled to the catheter shaft at a distal end thereof; and an electroporation generator coupled in communication with the at least one electrode, the electroporation generator configured to supply a biphasic pulse signal to the at least one electrode, the biphasic pulse signal comprising: a first phase having a first polarity and a first pulse duration; and a second phase having a second polarity opposite to the first polarity, and a second pulse duration, each of the first phase and second phase having a voltage amplitude of at least 500 volts and a pulse duration of less than 20 microseconds, wherein the second phase is generated at a non-zero interval following the first phase.

2 . The electroporation system of claim 1 , wherein each of the first and second phase has a voltage amplitude of at least 600 volts and a pulse duration of less than 3 microseconds.

3 . The electroporation system of claim 1 , wherein each of the first and second phase has a voltage amplitude of at least 600 volts and a pulse duration of less than 1.5 microseconds.

4 . The electroporation system of claim 1 , wherein each of the first pulse duration, the second pulse duration, and the non-zero interval is less than 3 microseconds.

5 . The electroporation system of claim 4 , wherein each of the first phase and second phase has a voltage amplitude of at least 600 volts.

6 . The electroporation system of claim 1 , wherein the electroporation generator is further configured to generate a burst signal comprising a plurality of the biphasic pulse signals, wherein each of the plurality of biphasic pulse signals is generated at a pulse period in a range of 0.5 milliseconds to 10 milliseconds.

7 . The electroporation system of claim 1 further comprising an electrode assembly coupled at the distal end of the catheter shaft, the electrode assembly including the at least one electrode, wherein the electrode assembly is configured as one of an electrode loop assembly, a basket electrode assembly, a planar electrode assembly, and an expandable electrode assembly comprising an expandable isolation member.

8 . The electroporation system of claim 7 , wherein the electrode assembly is configured as a bipolar electrode loop assembly, and wherein each of the first and second phase has a voltage amplitude of at least 600 volts and a pulse duration of less than 3 microseconds.

9 . The electroporation system of claim 8 , wherein each of the first and second phase has a voltage amplitude in the range of 600 volts to 1.4 kV, and a pulse duration in the range of 1 microsecond to 1.5 microseconds.

10 . The electroporation system of claim 7 , wherein the electrode assembly is configured as a monopolar electrode loop assembly, and wherein each of the first and second phase has a voltage amplitude of at least 800 volts and a pulse duration of less than 3 microseconds.

11 . The electroporation system of claim 10 , wherein each of the first and second phase has a voltage amplitude in the range of 800 volts to 3.0 kV, and a pulse duration in the range of 0.5 microseconds to 1.5 microseconds.

12 . The electroporation system of claim 7 , wherein the electrode assembly is configured as a bipolar expandable electrode assembly comprising an expandable isolation member, and wherein each of the first and second phase has a voltage amplitude of at least 500 volts and a pulse duration of less than 20 microseconds.

13 . The electroporation system of claim 12 , wherein each of the first and second phase has a voltage amplitude in the range of 600 volts to 2.5 kV, and a pulse duration in the range of 500 nanoseconds to 1.5 microseconds.

14 . A method comprising:
supplying, by an electroporation generator, a first phase of a biphasic pulse signal to at least one electrode coupled at a distal end of a catheter shaft, the first phase having a first polarity and a first pulse duration; and supplying a second phase of the biphasic pulse signal to the at least one electrode, the second phase having a second polarity opposite to the first polarity, and a second pulse duration, wherein each of the first phase and second phase has a voltage amplitude of at least 500 volts and a pulse duration of less than 20 microseconds, wherein the second phase is generated at a non-zero interval following the first phase.

15 . The method of claim 14 , wherein each of the first and second phase has a voltage amplitude of at least 600 volts and a pulse duration of less than 3 microseconds.

16 . The method of claim 14 , wherein each of the first and second phase has a voltage amplitude of at least 600 volts and a pulse duration of less than 1.5 microseconds.

17 . The method of claim 14 , wherein each of the first pulse duration, the second pulse duration, and the non-zero interval is less than 3 microseconds.

18 . The method of claim 17 , wherein each of the first phase and second phase has a voltage amplitude of at least 600 volts.

19 . The method of claim 14 further comprising supplying a burst signal to the at least one electrode, the burst signal comprising a plurality of the biphasic pulse signals, wherein each of the plurality of biphasic pulse signals is generated at a pulse period in a range of 0.5 milliseconds to 10 milliseconds.

20 . The method of claim 14 , wherein the at least one electrode is part of an electrode assembly coupled at the distal end of the catheter shaft, wherein the electrode assembly is configured as one of an electrode loop assembly, a basket electrode assembly, a planar electrode assembly, and an expandable electrode assembly comprising an expandable isolation member.

21 - 27 . (canceled)

Assignees

• St Jude Medical Cardiology Div Inc

Inventors

• Byrd Israel
• Olson Eric
• Drew Kenneth
• Tranter John
• Tegg Troy

Classifications

• A61B18/14 Primary

  Probes or electrodes therefor · CPC title

• A61B18/12 Primary

  by passing a current through the tissue to be heated, e.g. high-frequency current · CPC title

• A61B5/352

  Detecting R peaks, e.g. for synchronising diagnostic apparatus; Estimating R-R interval · CPC title

• A61B2018/00577

  Ablation · CPC title

• A61B2018/00351

  Heart · CPC title