Method for treating denture stomatitis using denture base material containing nanodiamonds

Patent metadata

Field	Value
Publication number	US-2021121272-A1
Application number	US-202017078756-A
Country	US
Kind code	A1
Filing date	Oct 23, 2020
Priority date	Oct 23, 2019
Publication date	Apr 29, 2021
Grant date	—

Abstract

A curable composite material containing nanodiamonds, denture bases and other dental prosthetics made from the composite material and methods for treating dental stomatitis using these prosthetics.

First claim

1 . A method for preventing or reducing the severity of denture stomatitis comprising:
providing a subject at risk of developing denture stomatitis with a denture comprising a denture base made of a composite material that contains a polymer suitable for use as a denture base into which nanodiamonds have been incorporated; or providing a subject who has denture stomatitis with a replacement denture comprising a denture base made of a composite material that contains a polymer suitable for use as a denture base into which nanodiamonds have been incorporated.

2 . The method of claim 1 , wherein the subject is at risk of developing denture stomatitis.

3 . The method of claim 1 , wherein the subject is at risk of developing denture stomatitis and has cancer, is immunosuppressed, is being treated with an antimicrobial drug, has high blood sugar or diabetes, or is otherwise at risk of developing an infection by Candida.

4 . The method of claim 1 , wherein the subject has denture stomatitis.

5 . The method of claim 1 , wherein the denture stomatitis is caused by a member of the genus Candida.

6 . The method of claim 1 , wherein the denture stomatitis is caused by Candida albicans.

7 . The method of claim 1 , wherein the polymer comprises poly(methylmethacrylate) (PMMA).

8 . The method of claim 1 , wherein the polymer comprises PMMA and rubber nanoparticles.

9 . The method of claim 1 , wherein the polymer is PMMA and has a molecular weight as measured by gel permeation chromatograph (GPC) of 300,000 to 3,000,000 g/mol.

10 . The method of claim 1 , wherein the composite material comprises about 0.25 to 2 wt. % nanodiamonds, relative to a total weight of the composite material.

11 . The method of claim 1 , wherein the nanodiamonds have an average particle size ranging from 20-40 nm.

12 . The method of claim 1 , wherein the nanodiamonds have an average particle size of about 30 nm and/or the nanodiamonds are uniformly distributed in the composite material so that the density of nanodiamonds between cm 3 different volumes of composite does not vary by more than 10%.

13 . A composite material suitable for use in dentures or dental implants comprising PMMA and 0.25 to 2 wt. % nanodiamonds based on a total weight of the composite material, wherein said nanodiamonds have an average particle size ranging from 20 to 40 nm.

14 . The composite material of claim 13 , wherein the nanodiamonds have an average diameter of about 30 nm.

15 . The composite material of claim 13 , wherein the nanodiamonds are present in an amount ranging from 0.5 to 1.5 wt. % of the composite material.

16 . The composite material of claim 13 which has a roughness R a of no more than 0.2 μm.

17 . The composite material of claim 13 which has a roughness R a of no more than 0.2 μm, wherein Candida albicans binds to said material less than a control or otherwise identical composite material not containing nanodiamonds.

18 . A partial denture, full denture, or other removable dental prosthetic comprising the composite material of claim 13 .

19 . A method for making the composite material of claim 13 comprising: mixing a powder comprising nanodiamonds having a particle size of about 20 to 40 nm with methyl methacrylate resin powder in a proportion of 98-99.75 wt. % of the resin powder to 2 to 0.25 wt. % nanodiamonds to form a mixture,
heat polymerizing the mixture to form PMMA,
casting a denture base from the polymerized PMMA, and,
polishing the denture base.

20 . The method of claim 19 , wherein the polishing is continued until the surface roughness (Ra) of the denture is no more than 0.2.

Assignees

• Univ Imam Abdulrahman Bin Faisal

Inventors

• Gad Mohammed Moustafa Ahmed
• Fouda Shaimaa Mohamed Said
• Al-Harbi Fahad A
• Al-Thobity Ahmad M
• Ellakany Passent Safwat Aly

Classifications

• A61C19/063

  Medicament applicators for teeth or gums, e.g. treatment with fluorides · CPC title

• A61C13/04 Primary

  made by casting · CPC title

• A61K6/887

  Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds · CPC title

• A61C13/087 Primary

  Artificial resin teeth {(A61C13/081 takes precedence; preparations A61K6/80)} · CPC title