Methods for increasing growth of beneficial bacteria in the gastrointestinal tract

Patent metadata

Field	Value
Publication number	US-2021113630-A1
Application number	US-201816625429-A
Country	US
Kind code	A1
Filing date	Jun 21, 2018
Priority date	Jun 21, 2017
Publication date	Apr 22, 2021
Grant date	—

Abstract

Disclosed are nutritional compositions including 2′-fucosyllactose (2′-FL) in combination with lutein and RRR-alpha-tocopherol. The nutritional compositions are useful for improving at least one of gut function, health, and development in an individual. In certain embodiments, the nutritional compositions can improve growth or maturation of the gut, as well as promote a healthy balance of beneficial bacteria in the gastrointestinal tract thereby treating and/or preventing formula intolerance or other gastrointestinal diseases and/or disorders resulting from suboptimal gastrointestinal flora population/balance.

First claim

1 . A method of improving gut health of an infant, the method comprising administering a nutritional composition comprising 2′-fucosyllactose, lutein, and RRR-alpha-tocopherol to an infant.

2 . The method of claim 1 , wherein administration increases beneficial bacteria in the gut of the infant.

3 . The method of claim 1 , wherein the nutritional composition comprises 2′-fucosyllactose in an amount of about 0.02 mg/mL to about 20 mg/mL.

4 . The method of claim 1 , wherein the nutritional composition comprises lutein in an amount of about 0.001 mg/mL to about 5 mg/mL

5 . The method of claim 1 , wherein the nutritional composition comprises RRR-alpha-tocopherol in an amount of about 3 mg/L to about 100 mg/L

6 . The method of claim 1 , wherein the nutritional composition is an infant formula.

7 . The method of claim 1 , wherein the nutritional composition further comprises a probiotic.

8 . The method of claim 1 , wherein the probiotic is a Bifidobacteria.

9 . The method of claim 1 , wherein the nutritional composition further comprises another human milk oligosaccharide.

10 . A method of increasing the beneficial bacteria in the gastrointestinal tract of an infant, the method comprising administering a nutritional composition comprising 2′-fucosyllactose, lutein, and RRR-alpha-tocopherol to an infant in need thereof.

11 . The method of claim 10 , wherein the beneficial bacteria is at least one of a Bifidobacteria and a Lactobacilli.

12 . The method of claim 10 , wherein the nutritional composition comprises 2′-fucosyllactose in an amount of about 0.02 mg/mL to about 20 mg/mL

13 . The method of claim 10 , wherein the nutritional composition comprises lutein in an amount of about 0.001 mg/mL to about 5 mg/mL

14 . The method of any claim 10 , wherein the nutritional composition comprises RRR-alpha-tocopherol in an amount of about 3 mg/L to about 100 mg/L

15 . The method claim 10 , wherein the nutritional composition is an infant formula.

16 . The method claim 10 , wherein the nutritional composition further comprises a probiotic.

17 . The method of claim 10 , wherein the nutritional composition further comprises another human milk oligosaccharide.

18 - 21 . (canceled)

Assignees

• Abbott Lab

Inventors

• Barranco alejandro perez
• Ramirez maria gonzalez
• Buck Rachael
• Vazquez Enrique Hernandez

Classifications

• A23L33/10 Primary

  using additives (addition of substantially indigestible substances A23L33/21) · CPC title

• A61K47/24

  containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids · CPC title

• A61K33/30

  Zinc; Compounds thereof · CPC title

• A61K31/708

  having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid · CPC title

• A61K35/747 Primary

  Lactobacilli, e.g. L. acidophilus or L. brevis · CPC title