Buffer management and identification in bioprocessing system
US-11899028-B2 · Feb 13, 2024 · US
US2021069647A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2021069647-A1 |
| Application number | US-201816763288-A |
| Country | US |
| Kind code | A1 |
| Filing date | Nov 29, 2018 |
| Priority date | Nov 30, 2017 |
| Publication date | Mar 11, 2021 |
| Grant date | — |
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A filtration device includes a continuous first unit including a first membrane that separates a liquid into first permeated and non-permeated liquids, a first adjuster that adjusts a flow rate of the first permeated liquid to be substantially constant, and a first liquid scale that detects a liquid amount, a second unit including a second membrane that separates another liquid into second permeated and non-permeated liquids, a second adjuster that adjusts a flow rate of the second permeated liquid to be substantially constant, and a second liquid scale that detects another liquid amount, a first controller that controls the liquid amount in the first storage tank based on measurement values from continuous two first units or from the continuous first and second units, and a second controller that controls the another liquid amount based on a measurement value from the second unit.
Opening claim text (preview).
1 .- 21 . (canceled) 22 . A filtration device comprising: a single or a plurality of continuous first membrane filtration units including a first storage tank configured to store therein a liquid to be treated, a first separation membrane part configured to separate the liquid to be treated into a first permeated liquid and a first non-permeated liquid, a first liquid delivery pipe configured to deliver the liquid to be treated from the first storage tank to the first separation membrane part, a first non-permeated liquid pipe configured to return the first non-permeated liquid to the first storage tank or the first liquid delivery pipe, a first permeated liquid pipe configured to cause the first permeated liquid to flow from the first separation membrane part, a first extraction pipe through which a portion of the first non-permeated liquid is extracted, a first adjustment unit configured to adjust a flow rate of the first permeated liquid to be substantially constant, and a first liquid scale configured to detect an amount of a stored liquid in the first storage tank; a second membrane filtration unit including a second storage tank configured to store therein the first permeated liquid from the first permeated liquid pipe of the single first membrane filtration unit or a last-stage one of the first membrane filtration units, a second separation membrane part configured to separate a stored liquid in the second storage tank into a second permeated liquid and a second non-permeated liquid, a second liquid delivery pipe configured to deliver the stored liquid in the second storage tank from the second storage tank to the second separation membrane part, a second non-permeated liquid pipe configured to return the second non-permeated liquid to the second storage tank or the second liquid delivery pipe, a second permeated liquid pipe configured to cause the second permeated liquid to flow from the second separation membrane part, a second extraction pipe through which a portion of the second non-permeated liquid is extracted, a second adjustment unit configured to adjust a flow rate of the second permeated liquid to be substantially constant, and a second liquid scale configured to detect an amount of the stored liquid in the second storage tank; a first controller unit configured to control an amount of a stored liquid stored in the first storage tank based on measurement values from the first liquid scales of continuous two of the first membrane filtration units or measurement values from the first and second liquid scales of the continuous first and second membrane filtration units; and a second controller unit configured to control an amount of a stored liquid stored in the second storage tank based on a measurement value from the second liquid scale. 23 . The filtration device according to claim 22 , wherein, based on a preceding-stage measurement value from a first liquid scale of a preceding first membrane filtration unit of the continuous two first membrane filtration units or the continuous first and second membrane filtration units and a subsequent-stage measurement value from a first or second liquid scale in a subsequent first or second membrane filtration unit, the first controller unit stops a flow of the first permeated liquid of the preceding first membrane filtration unit. 24 . The filtration device according to claim 23 , wherein when the preceding-stage measurement value is smaller than a first threshold or when the subsequent-stage measurement value is larger than a second threshold, the first controller unit adjusts the first adjustment unit of the preceding first membrane filtration unit to stop a flow of the first permeated liquid from the first permeated liquid pipe to the subsequent first or second membrane filtration unit. 25 . The filtration device according to claim 23 , wherein the first membrane filtration unit further includes a first open/close valve provided in the first permeated liquid pipe, and when the preceding-stage measurement value is smaller than a first threshold or when the subsequent-stage measurement value is larger than a second threshold, the first controller unit closes the first open/close valve of the preceding first membrane filtration unit to stop a flow of the first permeated liquid from the first permeated liquid pipe to the subsequent first or second membrane filtration unit. 26 . The filtration device according to claim 23 , wherein the first membrane filtration unit further includes a first permeated liquid returning pipe configured to return the first permeated liquid from the first permeated liquid pipe to the first storage tank, and a first non-permeated liquid returning pipe configured to return the first non-permeated liquid from the first extraction pipe to the first storage tank, and when the preceding-stage measurement value is smaller than a first threshold or when the subsequent-stage measurement value is larger than a second threshold, the first controller unit returns the first permeated liquid in the first permeated liquid pipe to the first storage tank through the first permeated liquid returning pipe and returns the first non-permeated liquid in the first extraction pipe to the first storage tank through the first non-permeated liquid returning pipe in the preceding first membrane filtration unit. 27 . The filtration device according to claim 22 , wherein, based on a subsequent-stage measurement value from a second liquid scale in a subsequent second membrane filtration unit of the continuous first and second membrane filtration units, the second controller unit stops a flow of the second permeated liquid of the subsequent second membrane filtration unit. 28 . The filtration device according to claim 27 , wherein when the subsequent-stage measurement value of the subsequent second membrane filtration unit is smaller than a third threshold, the second controller unit adjusts the second adjustment unit of the subsequent second membrane filtration unit to stop a flow of the second permeated liquid from the second permeated liquid pipe. 29 . The filtration device according to claim 27 , further comprising a second open/close valve provided in the second permeated liquid pipe, wherein when the subsequent-stage measurement value of the subsequent second membrane filtration unit is smaller than a third threshold, the second controller unit closes the second open/close valve of the subsequent second membrane filtration unit to stop a flow of the second permeated liquid from the second permeated liquid pipe. 30 . The filtration device according to claim 27 , wherein the second membrane filtration unit further includes a second permeated liquid returning pipe configured to return the second permeated liquid from the second permeated liquid pipe to the second storage tank and a second non-permeated liquid returning pipe configured to return the second non-permeated liquid from the second extraction pipe to the second storage tank, and when the subsequent-stage measurement value of the subsequent second membrane filtration unit is smaller than a third threshold, the second controller unit returns the second permeated liquid in the second permeated liquid pipe to the second storage tank through the second permeated liquid returning pipe, and returns the second non-permeated liquid in the second extraction pipe to the second storage tank through the second non-permeated liquid returning pipe. 31 . The filtration device according to claim 22 , wherein a first permeated liquid from a preceding one of the continuous first membrane filtration units is stored in a first storage tank of a subsequent one of the continuous first membrane filtration
Permeate storage tanks · CPC title
to feed side · CPC title
Backflushing · CPC title
Membrane cleaning or sterilisation {; Membrane regeneration} · CPC title
Purifying · CPC title
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