Compositions and Methods for Treatment of Edema

Patent metadata

Field	Value
Publication number	US-2021069164-A1
Application number	US-202016950652-A
Country	US
Kind code	A1
Filing date	Nov 17, 2020
Priority date	Feb 5, 2015
Publication date	Mar 11, 2021
Grant date	—

Abstract

Provided are pharmaceutical compositions and methods of treating or preventing edema, using an anti-T cell agent, an anti-TGF-β1 agent, or an anti-angiotensin agent, preferably a combination of at least two such agents. The pharmaceutical compositions can be formulated for systemic or local administration, and are preferably administered topically.

First claim

We claim:

1 . A method of preventing lymphedema, the method comprising administering to a cancer patient undergoing radiation therapy, chemotherapy, and/or surgical lymph node dissection a pharmaceutical composition comprising an effective amount of pirfenidone, wherein the pharmaceutical composition is administered prophylactically within about six weeks of the radiation therapy, chemotherapy, and/or surgical lymph node dissection.

2 . The method of claim 1 , wherein the pharmaceutical composition is administered topically.

3 . The method of claim 2 , wherein the pharmaceutical composition is in a form selected from the group consisting of an ointment, a cream, a lotion, a paste, a gel, a mousse, a foam, a lacquer, a suspension, a liquid, and a spray.

4 . The method of claim 3 , wherein the pharmaceutical composition is in the form of an ointment.

5 . The method of claim 2 , wherein the pharmaceutical composition is administered at least once a day.

6 . The method of claim 2 , wherein the pharmaceutical composition is administered at least twice a day.

7 . The method of claim 1 , wherein the pharmaceutical composition is administered orally.

8 . The method of claim 7 , wherein the pharmaceutical composition is in a form selected from the group consisting of a tablet, a capsule, a liquid, a solution, a softgel, a suspension, an emulsion, a syrup, and an elixir.

9 . The method of claim 8 , wherein the pharmaceutical composition is in the form of a tablet or a capsule.

10 . The method of claim 7 , wherein the pharmaceutical composition is administered at least once a day.

11 . The method of claim 7 , wherein the pharmaceutical composition is administered at least twice a day.

12 . The method of claim 1 , wherein the pharmaceutical composition is administered prophylactically within about two weeks of the radiation therapy, chemotherapy, and/or surgical lymph node dissection.

13 . The method of claim 1 , wherein the pharmaceutical composition is administered prophylactically within about one week of the radiation therapy, chemotherapy, and/or surgical lymph node dissection.

14 . The method of claim 13 , wherein the pharmaceutical composition is administered prophylactically about one week before the radiation therapy, chemotherapy, and/or surgical lymph node dissection.

15 . The method of claim 13 , wherein the pharmaceutical composition is administered prophylactically about 1, 2, 3, 4, 5, or 6 days before the radiation therapy, chemotherapy, and/or surgical lymph node dissection.

16 . The method of claim 14 , wherein the pharmaceutical composition is administered prophylactically on the same day as the radiation therapy, chemotherapy, and/or surgical lymph node dissection.

Assignees

• Memorial Sloan Kettering Cancer Center

Inventors

• Mehrara Babak
• Gardenier Jason
• Savetsky Ira
• Aras Omer

Classifications

• A61P7/10

  Antioedematous agents; Diuretics · CPC title

• A61K31/4418 Primary

  having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine · CPC title

• A61K9/0014 Primary

  Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00) · CPC title

• A61K31/401

  Proline; Derivatives thereof, e.g. captopril · CPC title

• A61K47/10

  Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers · CPC title