Zirconium-Based Cluster as an Antiperspirant and Deodorant Active

Patent metadata

Field	Value
Publication number	US-2021069074-A1
Application number	US-201816771945-A
Country	US
Kind code	A1
Filing date	Dec 10, 2018
Priority date	Dec 14, 2017
Publication date	Mar 11, 2021
Grant date	—

Abstract

Described herein are zirconium oxychloride clusters comprising zirconium oxychloride and a basic amino acid. Personal care compositions comprising the same, and methods of making and using the same are also described.

First claim

1 . A zirconium oxychloride cluster comprising:
a. zirconium oxychloride; and b. a basic amino acid; wherein the cluster has a radius of gyration of from 0.5 nm to 50 nm.

2 . The cluster of claim 1 , wherein the zirconium oxychloride cluster has a radius of gyration of from 0.5 nm to 20 nm, from 0.5 nm to 10 nm, from 0.7 nm to 10 nm, from 0.8 nm to 10 nm, from 1 nm to 10 nm, from 0.5 nm to 7 nm, from 0.6 nm to 6 nm, from 0.7 nm to 5 nm, from 0.8 nm to 3 nm, from 0.8 nm to 2.5 nm, or from 1 nm to 2 nm.

3 . The cluster of claim 1 , wherein the zirconium oxychloride cluster is stable at pH 2-6, 3-5, 3-4, 3.5-4.5 or 4-4.5.

4 . The cluster of claim 1 , wherein the zirconium oxychloride cluster exhibits a SEC chromatogram having a high peak at 6-8 minutes; wherein the SEC chromatogram is obtained under conditions wherein SEC chromatography is carried out using a 10 μm diol-bonded gel filtration column with 20 min run time and 1 mL/min flow rate and the mobile phase of the SEC chromatography consists of deionized water acidified with 1.01% w/w HNO 3 to pH 2.3.

5 . The cluster claim 1 , wherein the basic amino acid comprises arginine.

6 . The cluster of claim 1 prepared by a process comprising the steps of:
(a) combining a basic amino acid and zirconium oxychloride in an aqueous solution;
(b) incubating the solution at a temperature higher than 40° C.; and
(c) cooling the solution;

wherein the molar ratio of the basic amino acid to zirconium oxychloride in step (a) is less than 1.5.

7 . The cluster of claim 6 , wherein the molar ratio of the basic amino acid to zirconium oxychloride in step (a) is from 0.5 to 1.5, from 0.7 to 1.3, from 0.8 to 1.2, from 0.9 to 1.1, or about 1.

8 . The cluster of claim 6 , wherein the basic amino acid in step (a) is arginine.

9 . The cluster of claim 8 , wherein the arginine is L-arginine.

10 . The cluster of claim 6 , wherein the process further comprises the step of purifying the zirconium oxychloride cluster from the cooled solution.

11 . The cluster of claim 10 , wherein the zirconium oxychloride cluster is purified by gel permeation chromatography (GPC).

12 . The cluster of claim 11 , wherein the GPC column comprises polyacrylamide beads having a wet bead size of less than 45 μm and a 100-1,800 MW fractionation range.

13 . The cluster of claim 12 , wherein the purification comprises loading the cooled solution on the GPC column using a HPLC pump at 0.2 mL/min; and the mobile phase of the GPC chromatography is deionized water.

14 . The cluster of claim 13 , wherein GPC fraction is collected in the 1160-1300 minute interval and wherein the 1160-1300 minute interval fraction contains the purified zirconium cluster.

15 . A personal care composition comprising a zirconium oxychloride cluster according to claim 1 .

16 . The personal care composition of claim 15 , wherein the personal care composition comprises an aluminum containing antiperspirant active.

17 . The personal care composition of claim 15 , wherein the personal care composition does not contain any aluminum containing antiperspirant active.

18 . The personal care composition of claim 15 , wherein the personal care composition is selected from an antiperspirant, a deodorant, a body wash, a shower gel, a bar soap, a shampoo, a hair conditioner, and a cosmetic.

19 . A method of preparing a zirconium oxychloride cluster having a radius of gyration of from 0.5 nm to 50 nm, comprising the steps of:
(a) combining a basic amino acid and zirconium oxychloride in an aqueous solution; (b) incubating the solution at a temperature higher than 40° C.; and (c) cooling the solution; wherein the molar ratio of the basic amino acid to zirconium oxychloride in step (a) is less than 1.5.

20 . The method of claim 19 , wherein the molar ratio of the basic amino acid to zirconium oxychloride in step (a) is from 0.5 to 1.5, from 0.7 to 1.3, from 0.8 to 1.2, from 0.9 to 1.1, or about 1.

21 . (canceled)

22 . (canceled)

23 . (canceled)

24 . (canceled)

25 . (canceled)

Assignees

• Colgate Palmolive Co

Inventors

• Dubovoy Viktor
• Pan Long
• Subramanyam Ravi

Classifications

• C01G25/00 Primary

  Compounds of zirconium · CPC title

• A61K8/30

  containing organic compounds · CPC title

• A61K8/0275

  Containing agglomerated particulates · CPC title

• A61K8/44

  Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof · CPC title

• A61K8/28 Primary

  Zirconium; Compounds thereof · CPC title