Electrospun anti-adhesion barrier

Patent metadata

Field	Value
Publication number	US-2021060214-A1
Application number	US-202017006129-A
Country	US
Kind code	A1
Filing date	Aug 28, 2020
Priority date	Aug 28, 2019
Publication date	Mar 4, 2021
Grant date	—

Abstract

An article includes a fibrous mat of poly(glycerol sebacate) (PGS) resin and a resin of a hydrogel forming polymer, such as a polyvinyl alcohol (PVOH). Methods of making such articles include electrospinning a combination of PGS resin and PVOH resin to form nanofibers and depositing the nanofibers onto a surface to form the fibrous mat. The mat is suitable for a variety of medical uses, including as a barrier that can be deployed in surgical procedures.

First claim

What is claimed is:

1 . A method comprising
electrospinning a combination of poly(glycerol sebacate) (PGS) resin and a hydrogel forming polymer resin to form nanofibers; and depositing the nanofibers onto a surface to form a fibrous mat.

2 . The method of claim 1 , wherein the combination is free of a cross-linking agent.

3 . The method of claim 2 , wherein the hydrogel forming polymer resin is poly(vinyl alcohol) (PVOH) and the nanofibers exhibit cross-linking between the PGS and PVOH upon deposition onto the surface.

4 . The method of claim 3 , wherein the PGS and PVOH are a blend.

5 . The method of claim 4 , wherein the PGS and PVOH are blended in a common solvent to form a solution for the electrospinning.

6 . The method of claim 5 , wherein the total solids content of the solution is in the range of about 2% to about 10% by weight.

7 . The method of claim 6 , wherein the nanofibers are electrospun from the solution being pumped at a rate of about 1 microliter per minute to about 200 microliters per minute.

8 . The method of claim 1 comprising electrospinning at a voltage differential in the range of 5 kV to 70 kV.

9 . The method of claim 1 , wherein the surface onto which the nanofibers are deposited is a textile.

10 . The method of claim 1 , further comprising forming a pouch from the fibrous mat.

11 . The method of claim 1 , further comprising electrospinning a second set of nanofibers from a composition different than the combination of PGS and the hydrogel forming polymer and co-depositing the second set of nanofibers with the PGS-hydrogel forming nanofibers to form the fibrous mat.

12 . An article comprising a fibrous mat of nanofibers made according to the method of claim 1 .

13 . The article of claim 12 , wherein the hydrogel forming polymer is selected from the group consisting of PVOH, hyaluronic acid, carboxymethylcellulose, hydroxymethyl cellulose, alginate, collagen, gelatin, and combinations thereof.

14 . The article of claim 13 , wherein the hydrogel forming polymer comprises PVOH.

15 . The article of claim 12 , wherein the PGS has a weight average molecular weight in the range of about 2,000 Daltons to about 50,000 Daltons.

16 . The article of claim 12 , wherein the hydrogel forming polymer comprises PVOH having a weight average molecular weight in the range of about 10,000 Daltons to about 100,000 Daltons.

17 . The article of claim 12 , wherein the PGS has a weight average molecular weight in the range of about 10,000 to about 15,000 Daltons and the hydrogel forming polymer is PVOH having a weight average molecular weight in the range of about 10,000 Daltons to about 25,000 Daltons.

18 . The article of claim 17 , wherein the nanofibers are 40% to 60% by weight PGS and 60% to 40% by weight PVOH.

19 . The article of claim 12 , wherein the fibrous mat has a thickness of about 30 microns to about 500 microns.

20 . The article of claim 19 , wherein the fibrous mat has a thickness of about 100 microns to about 200 microns.

21 . The article of claim 12 , wherein the fibrous mat further comprises cellular materials.

22 . The article of claim 12 , wherein the fibrous mat further comprises an active ingredient.

23 . A method comprising placing the article of claim 12 on a tissue surface within a mammalian body.

24 . The method of claim 23 comprising placing the article as a barrier intermediate two adjacent tissue surfaces within the mammalian body.

25 . A method comprising
electrospinning a combination of PGS resin and a hydrogel forming polymer resin to form a first set of nanofibers; electrospinning a second material to form a second set of nanofibers; co-depositing the first set of nanofibers and the second set of nanofibers onto a surface to form a fibrous mat.

26 . The method of claim 25 , wherein the second set of nanofibers has a larger average cross-sectional diameter than the first set of nanofibers.

27 . The method of claim 26 , wherein electrospinning the second material comprises electrospinning a blend of PGS, PVOH and cells to form the second set of nanofibers.

28 . The method of claim 27 further comprising electrospinning a third material comprising collagen to form a third set of nanofibers and co-depositing the third set of nanofibers with the first and second sets of nanofibers to form the fibrous mat.

29 . The method of claim 28 comprising forming the fibrous mat as a synthetic extra cellular matrix (ECM) material.

Assignees

• Secant Group Llc

Inventors

• Harris Jeremy J
• Ely Jared
• Tascan Mevlut
• Gabriele Peter D
• Crumbling Todd

Classifications

• A61L2300/404

  Biocides, antimicrobial agents, antiseptic agents · CPC title

• A61L31/148

  Materials at least partially resorbable by the body · CPC title

• D10B2321/06

  polymers of unsaturated alcohols, e.g. polyvinyl alcohol, or of their acetals or ketals · CPC title

• A61L31/14 Primary

  Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials} · CPC title

• A61L31/041 Primary

  Mixtures of macromolecular compounds · CPC title