Method and apparatus for therapeutic hyperthermia during an mri scan

Patent metadata

Field	Value
Publication number	US-2021007884-A1
Application number	US-201916508005-A
Country	US
Kind code	A1
Filing date	Jul 10, 2019
Priority date	Jul 10, 2018
Publication date	Jan 14, 2021
Grant date	—

Abstract

A therapeutic hyperthermia device and method for using the same includes a cooling blanket dimensioned to at least partially cover a human, a conduit coupled to the cooling blanket, and cooling liquid. Each of the cooling blanket, conduit, and cooling liquid have a negligible effect on a magnetic resonance (MR) image taken by an MRI device. The cooling liquid may have a spin-lattice relaxation time (T1) and a spin-spin relaxation time (T2), where either or both of T1 and T2 are less than 2 milliseconds in duration. The cooling liquid may be one of water with manganite chloride, and water with sodium chloride.

First claim

1 . An apparatus for therapeutic hyperthermia of a human during a magnetic resonance (MR) imaging (MRI) by an MRI device, the apparatus comprising:
a cooling blanket dimensioned to make contact with at least a portion of the human; a conduit coupled to the cooling blanket; and a cooling liquid within the conduit, wherein:
each of the cooling blanket, conduit, and cooling liquid have a negligible effect on an MR image.

2 . The apparatus of claim 1 , wherein the cooling blanket comprises one of:
two external surfaces and the conduit is coupled to at least one external surface; and two internal surfaces and the conduit is coupled to at least one internal surface.

3 . The apparatus of claim 1 , wherein the conduit is integrally formed within the cooling blanket.

4 . The apparatus of claim 1 , wherein the cooling liquid has a spin-lattice relaxation time (T 1 ) and a spin-spin relaxation time (T 2 ), and where at least one of T 1 and T 2 are less than 2 milliseconds in duration.

5 . The apparatus of claim 1 , wherein the cooling liquid is one of: water with manganite chloride, and water with sodium chloride.

6 . The apparatus of claim 1 , further comprising a temperature sensor coupled to the cooling blanket, the temperature sensor being operative to measure a temperature of at least one of: the human, the cooling blanket, and the cooling liquid, wherein the temperature sensor has a negligible effect on the MR image.

7 . The apparatus of claim 1 , wherein the temperature sensor is a fiber optic sensor.

8 . The apparatus of claim 1 , further comprising a cooling unit, wherein the cooling unit is operative to:
pump the cooling liquid through the conduit; and adjust at least one of:
a temperature of the cooling fluid based on a measured temperature of at least one of: the human, the cooling blanket, and the cooling liquid; and
a flowrate of the cooling fluid based on the measured temperature.

9 . A method for therapeutic hyperthermia of a human during a magnetic resonance (MR) imaging (MRI) by an MRI device, the method comprising:
providing a cooling blanket with a conduit, wherein the cooling blanket is dimensioned to make contact with at least a portion of the human; and pumping a cooling liquid through the conduit, wherein each of the cooling blanket, conduit, and cooling liquid have a negligible effect on an MR image.

10 . The method of claim 9 , wherein the cooling liquid has a spin-lattice relaxation time (T 1 ) and a spin-spin relaxation time (T 2 ), and where at least one of T 1 and T 2 are less than 2 milliseconds in duration.

11 . The method of claim 9 , wherein the cooling liquid is one of: water with manganite chloride, and water with sodium chloride.

12 . The method of claim 9 , further comprising measuring, using a temperature sensor coupled to the cooling blanket, the temperature sensor a temperature of at least one of: the human, the cooling blanket, and the cooling liquid, wherein the temperature sensor has a negligible effect on the MR image.

13 . The method of claim 9 , further comprising adjusting at least one of:
a temperature of the cooling fluid based on a measured temperature of at least one of: the human, the cooling blanket, and the cooling liquid; and a flowrate of the cooling fluid based on the measured temperature.

14 . An apparatus for therapeutic hyperthermia of a human during a magnetic resonance (MR) imaging (MRI) by an MRI device, the apparatus comprising:
a cooling blanket dimensioned to make contact with at least a portion of the human; a conduit coupled to the cooling blanket; and a cooling liquid, a cooling unit operative to:
pump the cooling liquid through the conduit; and
adjust at least one of:
a temperature of the cooling fluid based on a measured temperature of at least one of: the human, the cooling blanket, and the cooling liquid; and
a flowrate of the cooling fluid based on the measured temperature;

wherein each of the cooling blanket, conduit, and cooling liquid have a negligible effect on an MR image.

15 . The apparatus of claim 14 , wherein the cooling liquid has a spin-lattice relaxation time (T 1 ) and a spin-spin relaxation time (T 2 ), and where at least one of T 1 and T 2 are less than 2 milliseconds in duration.

16 . The apparatus of claim 14 , wherein the cooling liquid is one of: water with manganite chloride, and water with sodium chloride.

17 . The apparatus of claim 14 , further comprising a temperature sensor coupled to the cooling blanket, the temperature sensor being operative to provide the measured temperature, wherein the temperature sensor has a negligible effect on the MR image.

18 . A method for therapeutic hyperthermia of a human during a magnetic resonance (MR) imaging (MRI) by an MRI device, the method comprising:
providing a cooling blanket with a conduit, wherein the cooling blanket is dimensioned to make contact with at least a portion of the human; pumping a cooling liquid through the conduit; and adjust at least one of:
a temperature of the cooling fluid based on a measured temperature of at least one of: the human, the cooling blanket, and the cooling liquid; and
a flowrate of the cooling fluid based on the measured temperature,
wherein each of the cooling blanket, conduit, and cooling liquid have a negligible effect on an MR image.

19 . The method of claim 18 , wherein the cooling liquid has a spin-lattice relaxation time (T 1 ) and a spin-spin relaxation time (T 2 ), and where at least one of T 1 and T 2 are less than 2 milliseconds in duration.

20 . The method of claim 18 , wherein the cooling liquid is one of: water with manganite chloride, and water with sodium chloride.

Assignees

• Aspect Imaging Ltd

Inventors

• Rapoport Uri
• Strauss Noa
• Azulay Shmuel

Classifications

• A61B5/055

  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging · CPC title

• G01R33/28

  Details of apparatus provided for in groups G01R33/44 - G01R33/64 · CPC title

• A61B5/015

  By temperature mapping of body part · CPC title

• A61N5/025

  Warming the body, e.g. hyperthermia treatment · CPC title

• A61F2007/0056

  for cooling · CPC title