Apparatus and methods for mapping high energy radiation dose during radiation treatment

Patent metadata

Field	Value
Publication number	US-2021001153-A1
Application number	US-201916975301-A
Country	US
Kind code	A1
Filing date	Feb 22, 2019
Priority date	Feb 22, 2018
Publication date	Jan 7, 2021
Grant date	—

Abstract

A system for dosimetry includes a radiation source that provides a pulsed radiation beam to a treatment zone, and a thin sheet of scintillator disposed between the radiation source and skin of a subject in the treatment zone. A gated camera images the scintillator integrating light from the scintillator during multiple pulses of the radiation beam while excluding light received between pulses of the pulsed radiation beam; and an image capture and processing machine that receives images from the gated camera and performs additional corrections to provide a map of dose received by the subject.

First claim

1 . A system for dosimetry, comprising:
a radiation source adapted to provide a pulsed radiation beam to a treatment zone; a thin sheet of scintillator disposed between the radiation source and skin of a subject, the thin sheet of scintillator being in the treatment zone; a gated camera configured to image the sheet of scintillator; and an image capture and processing machine coupled to receive images from the gated camera; wherein the gated camera is configured to capture images of light from the thin sheet of scintillator during a plurality of pulses of the pulsed radiation beam while excluding light received from the thin sheet of scintillator between pulses of the plurality of pulses of the pulsed radiation beam to form a scintillation image.

2 . The system of claim 1 wherein the thin sheet of scintillator is a conformal sheet of scintillating material in contact with skin of the subject.

3 . The system of claim 2 wherein the system further comprises a 3-D imaging camera, and wherein the image capture and processing machine is configured to process images from the 3-D imaging camera into a three-dimensional model of the subject and to use the three-dimensional model of the subject to correct the scintillation image while determining a corrected total dose image.

4 . The system of claim 1 wherein the image capture and processing machine is configured to subtract a background image from the scintillation image, the background image being obtained by the gated camera at times excluding times of pulses of the pulsed radiation beam.

5 . The system of claim 4 wherein the system further comprises a 3-D imaging camera, and wherein the image capture and processing machine is configured to process images from the 3-D imaging camera into a three dimensional model of the subject and to use the three dimensional model of the subject to correct the scintillation image while determining a corrected total dose image.

6 . The system of claim 5 wherein the image capture and processing machine further comprises a database containing calibration information associated with individual thin sheets of scintillator, and the image capture and processing machine is configured to correct the scintillation image according to the calibration information.

7 .- 16 . (canceled)

Assignees

• Dartmouth College

Inventors

• Pogue Brian W
• Bruza Petr
• Gladstone David
• Jarvis Lesley A
• Tendler Irwin

Classifications

• A61B5/4836

  Diagnosis combined with treatment in closed-loop systems or methods (A61B5/0036 takes precedence) · CPC title

• A61B5/1455

  using optical sensors, e.g. spectral photometrical oximeters · CPC title

• G01T1/023

  Scintillation dose-rate meters · CPC title

• A61N2005/1096

  Elements inserted into the radiation path placed on the patient, e.g. bags, bolus, compensators · CPC title

• A61N2005/1059

  using cameras imaging the patient · CPC title