Genetically modified bacillus subtilis strain and use as a live delivery and production system
US-2024390433-A1 · Nov 28, 2024 · US
US2021000913A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2021000913-A1 |
| Application number | US-202017021113-A |
| Country | US |
| Kind code | A1 |
| Filing date | Sep 15, 2020 |
| Priority date | Mar 16, 2018 |
| Publication date | Jan 7, 2021 |
| Grant date | — |
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The present invention provides a coated-type feed additive composition for improving body weight gain of livestock or feed conversion ratio for livestock comprising: a core containing a physiologically active substance having a property of strengthening a membrane of intestinal epithelial cells; and a core coating agent.
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What is claimed is: 1 . A coated-type feed additive composition for improving body weight gain of livestock or feed conversion ratio for livestock comprising: a core containing a physiologically active substance having a property of strengthening a membrane of intestinal epithelial cells; and a core coating agent. 2 . A coated-type feed additive composition for improving body weight gain of livestock or feed conversion ratio for livestock according to claim 1 , wherein the physiologically active substance contains at least one selected from the group consisting of bacteriocins, polyphenols, amino acids or derivatives thereof, organic acids or derivatives thereof, HSP inducers, antioxidants, and polysaccharides. 3 . A coated-type feed additive composition for improving body weight gain of livestock or feed conversion ratio for livestock according to claim 1 , wherein the physiologically active substance is at least one bacteriocin selected from the group consisting of nisin, subtilin, plantaricin, and gassericin. 4 . A coated-type feed additive composition for improving body weight gain of livestock or feed conversion ratio for livestock according to claim 1 , wherein the physiologically active substance is contained in a culture of a microorganism which produces the substance. 5 . A coated-type feed additive composition for improving body weight gain of livestock or feed conversion ratio for livestock according to claim 1 , wherein the physiologically active substance is contained in a culture of at least one microorganism selected from the group consisting of Bacillus, Lactococcus, Lactobacillus, Leuconostoc , and Pediococcus. 6 . A coated-type feed additive composition for improving body weight gain of livestock or feed conversion ratio for livestock according to claim 5 , wherein the microorganism is Bacillus subtilis, Lactococcus lactis , or Lactobacillus plantarum. 7 . A coated-type feed additive composition for improving body weight gain of livestock or feed conversion ratio for livestock according to claim 2 , wherein the polyphenol is quercetin or tannin. 8 . A coated-type feed additive composition for improving body weight gain of livestock or feed conversion ratio for livestock according to claim 2 , wherein the amino acid is at least one selected from the group consisting of glutamine, phenylalanine, tryptophan, valine, and tyrosine. 9 . A coated-type feed additive composition for improving body weight gain of livestock or feed conversion ratio for livestock according to claim 2 , wherein the HSP inducer is polyphosphoric acid or a competence and sporulation factor. 10 . A coated-type feed additive composition for improving body weight gain of livestock or feed conversion ratio for livestock according to claim 1 , wherein the coating agent contains at least one selected from the group consisting of hydrogenated vegetable oil, shellac, zein, hydroxypropyl methylcellulose, and maltitol. 11 . A coated-type feed additive composition for improving body weight gain of livestock or feed conversion ratio for livestock according to claim 1 , wherein the physiologically active substance is at least one bacteriocin selected from the group consisting of nisin, subtilin, plantaricin, and gassericin, and the coating agent is hydrogenated rapeseed oil and/or shellac. 12 . A coated-type feed additive composition for improving body weight gain of livestock or feed conversion ratio for livestock according to claim 11 , wherein a coating layer formed by the coating agent has a two-layer structure including a layer formed of hydrogenated rapeseed oil and a layer formed of shellac. 13 . A coated-type feed additive composition for improving body weight gain of livestock or feed conversion ratio for livestock according to claim 12 , wherein the layer formed of shellac is in contact with the core, and the layer formed of hydrogenated rapeseed oil is formed thereon. 14 . A feed comprising: the coated-type feed additive composition for improving body weight gain of livestock or feed conversion ratio for livestock according to claim 1 . 15 . A method of improving a body weight gain of livestock and feed conversion ratio for livestock, comprising: administering to the coated-type feed additive composition according to claim 1 . 16 . The method according to claim 15 , wherein the physiologically active substance contains at least one selected from the group consisting of bacteriocins, polyphenols, amino acids or derivatives thereof, organic acids or derivatives thereof, HSP inducers, antioxidants, and polysaccharides. 17 . The method according to claim 15 , wherein the physiologically active substance is at least one bacteriocin selected from the group consisting of nisin, subtilin, plantaricin, and gassericin. 18 . The method according to claim 15 , wherein the physiologically active substance is contained as a culture of a microorganism which produces the substance. 19 . The method according to claim 15 , wherein the physiologically active substance is contained as a culture of at least one microorganism selected from the group consisting of Bacillus, Lactococcus, Lactobacillus, Leuconostoc , and Pediococcus. 20 . The method according to claim 19 , wherein the microorganism is Bacillus subtilis, Lactococcus lactis , or Lactobacillus plantarum.
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