Pharmaceutical compositions comprising silica microspheres

Patent metadata

Field	Value
Publication number	US-2021000741-A1
Application number	US-202017023625-A
Country	US
Kind code	A1
Filing date	Sep 17, 2020
Priority date	Apr 14, 2006
Publication date	Jan 7, 2021
Grant date	—

Abstract

Topical vaginal compositions are disclosed herein which include silica microspheres and an active ingredient in the amount of 0.001 to 15.0% w/w selected from estradiol, metronidazole, clindamycin, butoconazole, and combinations thereof. The topical compositions provide sustained release of the active ingredient so as to reduce skin irritation.

First claim

What is claimed is:

1 - 20 . (canceled)

21 . A sustained release composition for topical application of pharmaceuticals comprising:
silica microspheres impregnated with benzoyl peroxide, wherein the composition comprises about 5% w/w benzoyl peroxide and silica; and said composition is formulated for sustained release of said benzoyl peroxide.

22 . The sustained release composition of claim 21 , wherein some of the active ingredients are free in the composition, and the active ingredients impregnated in the silica microspheres provides sustained release of the active ingredients.

23 . The sustained release composition of claim 21 , wherein the composition is formulated as a foam.

24 . The sustained release composition of claim 21 , wherein said sustained release composition is formulated in a semisolid form.

25 . The sustained release composition of claim 24 , wherein the semisolid form is a gel, a cream, a paste, a lotion, an ointment, a shampoo, a semisolid powder or a suspension.

26 . The sustained release composition of claim 21 , wherein the silica microspheres have a mean microsphere size in the range of 0.5 micron to 40 microns.

27 . The sustained release composition of claim 21 , wherein the silica microspheres have a mean microsphere size in the range of 1 micron to 20 microns.

28 . The sustained release composition of claim 21 further comprising one or more of a solvent, an antioxidant, an antimicrobial preservative, an emulsifier, and water.

29 . The sustained release composition of claim 28 , wherein the solvent is selected from the group consisting of isopropanol, oleic acid, glycerol monooleate, oleyl alcohol, propylene glycol, isopropyl myristate, and combinations thereof.

30 . A method of treating rosacea and acne in a patient in need thereof, said method comprising topically administering to a rosacea or acne affected skin surface of said patient the sustained release composition of claim 21 .

Assignees

• Sol Gel Tech Ltd

Inventors

• Shevachman Marina
• Ze' Evi Amira
• Asculai Eilon
• Benyaminovich Batella
• Avram Nir
• Aschkenasy Chaim

Classifications

• A61K31/192

  having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid  {(cannabinoids A61K31/658)} · CPC title

• A61K31/05

  Phenols {(cannabinoids A61K31/658)} · CPC title

• A61K31/4174

  Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole · CPC title

• A61K9/0034 Primary

  Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants · CPC title

• A61K9/1611

  Inorganic compounds · CPC title