Dental composition

Patent metadata

Field	Value
Publication number	US-2020405585-A1
Application number	US-201916977905-A
Country	US
Kind code	A1
Filing date	Mar 5, 2019
Priority date	Mar 7, 2018
Publication date	Dec 31, 2020
Grant date	—

Abstract

The present invention relates to a dental composition comprising a radically polymerizable compound, a redox initiator system comprising one or more clathrate compounds comprising a host molecule and one or more guest molecules, wherein the host molecule is selected from cyclodextrines, crown ethers, cucurbituriles and calixarenes and the one or more guest molecules are reducing agents, and an oxidizing agent. Furthermore, the present invention relates to a use of the redox initiator system in a dental composition.

First claim

1 . A dental composition comprising
(i) a radically polymerizable compound; and (ii) a redox initiator system comprising
(a) one or more clathrate compounds comprising
(a1) a host molecule and
(a2) one or more guest molecules,
wherein the host molecule is selected from cyclodextrines, crown ethers, cucurbituriles and calixarenes, and the one or more guest molecules are reducing agents; and

(b) an oxidizing agent.

2 . The dental composition according to claim 1 , wherein the reducing agent is an aromatic tertiary amine, a phosphine or a borane.

3 . The dental composition according to claim 1 , wherein the reducing agent is a tertiary amine of the following formula (I):

wherein
R 1 and R 2 which may be the same or different, independently represent straight chain, branched or cyclic C 1-8 alkyl group, or R 1 and R 2 form together with the nitrogen atom to which they are bonded a 3-8 membered saturated heterocyclic ring; and
R 3 represents an organic group.

4 . The dental composition according to claim 3 , wherein the reducing agent is 4-tert.-butyl-N,N-dimethylaniline.

5 . The dental composition according to claim 1 , wherein the cyclodextrin is a natural non-reduced oligo-saccharide or a derivative thereof in which glucose is linked in a cyclic form through α-1,4-linkage.

6 . The dental composition according to claim 5 , wherein the natural cyclodextrin contains 5 to 8 glucose moieties.

7 . The dental composition according to claim 1 , wherein the molar ratio of the guest molecules: the host molecules is in the range of from 1:0.5 to 1:3.

8 . The dental composition according to claim 1 , wherein the oxidizing agent is a peroxide which is selected from cumyl hydroperoxide, tert-buy peroxybenzoate, tert-butylperoxy (2-ethylhexyl)carbonate, tert-butylhydroperoxide, di(tert-butyl)peroxide, tert-butylperoxy-3,5,5-trimethyl-hexanoate, potassium peroxydisufate.

9 . The dental composition according to claim 1 , which is a resin modified dental cement composition.

10 . The dental composition according to claim 1 , which is a two-pack dental composition.

11 . The dental composition according to claim 1 , wherein the redox initiator system including the one or more clathrate compounds and the oxidising agent are stored as a mixture in a single pack.

12 . The dental composition according to claim 1 , wherein the redox initiator system comprises:
(a) one or more clathrate compounds comprising a host molecule and one or more guest molecules, wherein the host molecule is selected from cyclodextrines, crown ethers, cucurbituriles and calixarenes, and the one or more guest molecules are reducing agents; and (b) an oxidising agent.

13 . (canceled)

14 . (canceled)

Assignees

• Dentsply Detrey Gmbh
• Dentsply Sirona Inc

Inventors

• Szillat Florian
• Renn Caroline
• Scheufler Christian
• Brenneisen Jörg

Classifications

• A61K6/60

  comprising organic or organo-metallic additives · CPC title

• A61K6/898

  Polysaccharides · CPC title

• A61K6/61 Primary

  Cationic, anionic or redox initiators · CPC title

• A61K6/889

  Polycarboxylate cements; Glass ionomer cements · CPC title