Detection of catecholamine levels inside the neurocranium

Patent metadata

Field	Value
Publication number	US-2020405204-A1
Application number	US-202016944977-A
Country	US
Kind code	A1
Filing date	Jul 31, 2020
Priority date	Apr 22, 2016
Publication date	Dec 31, 2020
Grant date	—

Abstract

Embodiments of the present invention may provide techniques that provide improved detection of catecholamines, such as dopamine. For example, in an embodiment, a method for catecholamine sensing may comprise outputting a signal responsive to a level of at least one catecholamine in neural tissue from a catecholamine sensor, analyzing the signal responsive to a catecholamine level in the neural tissue using circuitry connected to the catecholamine sensor, the circuitry comprising at least one computing device comprising a processor, memory accessible by the processor, and program instructions stored in the memory and executable by the processor, generating, using the circuitry, data representing the catecholamine level in the neural tissue, and transmitting the generated data representing the catecholamine level in the neural tissue using communication circuitry.

First claim

What is claimed is:

1 . A method for catecholamine sensing comprising:
outputting a signal responsive to a level of at least one catecholamine in neural tissue from a catecholamine sensor; analyzing the signal responsive to a catecholamine level in the neural tissue using circuitry connected to the catecholamine sensor, the circuitry comprising at least one computing device comprising a processor, memory accessible by the processor, and program instructions stored in the memory and executable by the processor; generating, using the circuitry, data representing the catecholamine level in the neural tissue; and transmitting the generated data representing the catecholamine level in the neural tissue using communication circuitry.

2 . The system of claim 1 , wherein the catecholamine sensor comprises a plurality of single walled carbon nanotubes.

3 . The system of claim 2 , wherein the plurality of single walled carbon nanotubes are coated with at least one of tetrafluoroethylene and perfluoroether.

4 . The system of claim 3 , wherein the plurality of single walled carbon nanotubes are coated with a tetrafluoroethylene main chain with perfluoroether side chains terminated with a sulfonic acid group.

5 . The system of claim 4 , wherein the coating of the plurality of single walled carbon nanotubes improves the detection of catecholamines.

6 . The system of claim 5 , wherein the detected catecholamine comprises epinephrine, norepinephrine, or dopamine.

7 . The system of claim 1 , wherein the catecholamine sensor comprises a plurality of structures including at least one of graphene, carbon nanohorns, graphene nanofoams, graphene nanorods, and graphene nanoflowers.

8 . The system of claim 1 , wherein the system comprises a device implanted in the neurocranium.

9 . A catecholamine sensor system comprising:
a catecholamine sensor configured to output a signal responsive to a level of at least one catecholamine in neural tissue; circuitry connected to the catecholamine sensor comprising at least one computing device comprising a processor, memory accessible by the processor, and program instructions stored in the memory and executable by the processor to cause the processor to perform: analyzing the signal responsive to a catecholamine level in the neural tissue, and generating data representing the catecholamine level in the neural tissue; and communication circuitry configured to transmit the generated data representing the catecholamine level in the neural tissue.

10 . The system of claim 9 , wherein the catecholamine sensor comprises a plurality of single walled carbon nanotubes.

11 . The system of claim 10 , wherein the plurality of single walled carbon nanotubes are coated with at least one of tetrafluoroethylene and perfluoroether.

12 . The system of claim 11 , wherein the plurality of single walled carbon nanotubes are coated with a tetrafluoroethylene main chain with perfluoroether side chains terminated with a sulfonic acid group.

13 . The system of claim 12 , wherein the coating of the plurality of single walled carbon nanotubes improves the detection of catecholamines.

14 . The system of claim 13 , wherein the detected catecholamine comprises epinephrine, norepinephrine, or dopamine.

15 . The system of claim 9 , wherein the catecholamine sensor comprises a plurality of structures including at least one of graphene, carbon nanohorns, graphene nanofoams, graphene nanorods, and graphene nanoflowers.

16 . The system of claim 9 , wherein the system comprises a device implanted in the neurocranium.

Assignees

• Howard Newton

Inventors

• Howard Newton

Classifications

• A61N1/3605

  Implantable neurostimulators for stimulating central or peripheral nerve system · CPC title

• A61N1/0531

  Brain cortex electrodes · CPC title

• B82Y30/00

  Nanotechnology for materials or surface science, e.g. nanocomposites · CPC title

• A61B5/4088

  Diagnosing of monitoring cognitive diseases, e.g. Alzheimer, prion diseases or dementia · CPC title

• A61B5/168

  Evaluating attention deficit, hyperactivity · CPC title