Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise

Patent metadata

Field	Value
Publication number	US-2020397291-A1
Application number	US-202017009463-A
Country	US
Kind code	A1
Filing date	Sep 1, 2020
Priority date	May 18, 2007
Publication date	Dec 24, 2020
Grant date	—

Abstract

Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.

First claim

What is claimed is:

1 . An electrochemical continuous glucose sensor configured for implantation in a host, the glucose sensor comprising:
an electrode configured to measure a signal indicative of a glucose concentration of a host, wherein the signal comprises a glucose-related component and a non-glucose related component; and a membrane covering at least a portion of the electrode, wherein the membrane is configured to reduce passage of an interfering species therethrough, whereby the non-glucose-related component of the signal is less than about 20% of the signal over a period of at least one day; wherein the glucose sensor has a sensitivity to glucose of from about 25 pA/mg/dL to about 500 pA/mg/dL.

2 . The glucose sensor of claim 1 , wherein the interfering species has an oxidation potential that overlaps with an oxidation potential of a measured species indicative of the concentration of the analyte.

3 . The glucose sensor of claim 1 , wherein the measured species is a product of an enzymatic reaction between glucose and an enzyme and is measured by the electrode.

4 . The glucose sensor of claim 1 , wherein the membrane comprises a silicone-containing polymer.

5 . The glucose sensor of claim 4 , wherein the silicone-containing polymer is a polysiloxanes.

6 . The glucose sensor of claim 4 , wherein the silicone-containing polymer is a polycarbosiloxane.

7 . The glucose sensor of claim 4 wherein the silicone-containing polymer is a copolymer comprising a silicone segment and a polyurethane segment.

8 . The glucose sensor of claim 1 , wherein the membrane comprises a fluorocarbon-based material.

9 . The glucose sensor of claim 1 , wherein the non-glucose-related component is less than about 10% of the signal over a time period of at least about one day.

10 . The glucose sensor of claim 1 , wherein the glucose sensor has a sensitivity to glucose of from about 25 pA/mg/dL to about 100 pA/mg/dL.

11 . The glucose sensor of claim 1 , wherein the glucose sensor comprises an enzyme configured to react with glucose.

12 . An electrochemical continuous glucose sensor configured for implantation in a host, the glucose sensor comprising:
an electrode configured to measure a signal indicative of a glucose concentration of a host, wherein the signal comprises a glucose-related component and a non-glucose related component; and an enzyme-containing membrane covering at least a portion of the electrode, wherein the enzyme-containing membrane comprises an outer domain comprising a discontinuously hydrophilic surface, wherein the outer domain comprises at least about 5 wt. % of a hydrophilic component.

13 . The glucose sensor of claim 12 , wherein the discontinuously hydrophilic outer domain comprises a blend comprising a silicone-containing polymer and a hydrophilic polymer.

14 . The glucose sensor of claim 12 , wherein the membrane comprises a fluorocarbon-based material.

15 . The glucose sensor of claim 12 , wherein the hydrophilic polymer is a copolymer of poly(ethylene oxide) and poly(propylene oxide).

16 . The glucose sensor of claim 12 , wherein the discontinuously hydrophilic outer domain comprises a polyurethane-based domain that has been surface-treated with a polymer containing hydrophilic moieties

17 . The glucose sensor of claim 12 , wherein the outer domain comprises at least about 15 wt. % of a hydrophilic component.

18 . The glucose sensor of claim 12 , wherein the outer domain comprises at least about 25 wt. % of a hydrophilic component.

19 . The glucose sensor of claim 12 , wherein the glucose sensor has a sensitivity to glucose of from about 25 pA/mg/dL to about 500 pA/mg/dL.

20 . The glucose sensor of claim 12 , wherein the glucose sensor has a sensitivity to glucose of from about 25 pA/mg/dL to about 100 pA/mg/dL.

Assignees

• Dexcom Inc

Inventors

• Simpson Peter C
• Boock Robert J
• Brister Mark C
• Rixman Monica A
• Woo Kum Ming
• Nguyen Lisa
• Brunner Seth R
• Chee Arthur
• Nicholas Melissa A
• Wightlin Matthew D
• Pryor Jack
• Markovic Dubravka

Classifications

• A61B5/14532 Primary

  for measuring glucose, e.g. by tissue impedance measurement · CPC title

• A61B5/14546

  for measuring analytes not otherwise provided for, e.g. ions, cytochromes · CPC title

• A61B5/1473

  invasive, e.g. introduced into the body by a catheter · CPC title

• A61B5/14865

  invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors · CPC title

• A61B5/14735

  comprising an immobilised reagent · CPC title