Hydroxyapatite based composition and film thereof comprising inorganic fullerene-like nanoparticles or inorganic nanotubes

Patent metadata

Field	Value
Publication number	US-2020392001-A1
Application number	US-201916970958-A
Country	US
Kind code	A1
Filing date	Feb 21, 2019
Priority date	Feb 22, 2018
Publication date	Dec 17, 2020
Grant date	—

Abstract

This invention is directed to compositions and films comprising hydroxyapatite with minute amounts of doped inorganic fullerene-like (IF) nanoparticles or doped inorganic nanotubes (INT); methods of preparation and uses thereof.

First claim

1 . A composition comprising hydroxyapatite [Ca 10 (PO 4 ) 6 (OH) 2 )] and inorganic fullerene-like nanoparticles or inorganic nanotubes; wherein the inorganic fullerene-like nanoparticles or inorganic nanotubes is A 1−x B x -chalcogenide where A is a metal or transition metal or an alloy of one metals or transition metals including at least one of the following: Mo, W, Re, Ti, Zr, Hf, Nb, Ta, Pt, Ru, Rh, In, Ga, InS, InSe, GaS, GaSe, WMo, TiW; and B (dopant) is a metal transition metal selected from the following: Si, Nb, Ta, W, Mo, Sc, Y, La, Hf, Ir, Mn, Ru, Re, Os, V, Au, Rh, Pd, Cr, Co, Fe, Ni; x is below or equal 0.003; and the chalcogenide is selected from the S, Se, Te.

2 . The composition according to claim 1 , wherein the inorganic fullerene-like nanoparticles or inorganic nanotubes are WS 2 , MoS 2 or combination thereof.

3 . The composition according to claim 1 , wherein the concentration of the dopant is below or equal to 0.3 at %.

4 . The composition according to claim 1 , wherein the composition further comprises brushite, portlandite or combination thereof.

5 . The composition according to claim 1 , wherein composition is deposited on a substrate forming a film.

6 . The composition according to claim 5 , wherein the substrate is a biocompatible.

7 . The composition according to claim 6 , wherein the substrate is a titanium, alloys of titanium, Co—Cr alloys, magnesium, stainless steel, shape memory alloys of nickel-titanium, silver, tantalum, zirconium and novel ceramics or any electrical-conductive substrate.

8 . The composition according to claim 7 , wherein the titanium is porous.

9 . The composition according to claim 1 , wherein the concentration of the doped inorganic fullerene-like nanoparticles is between 0.2 wt % to 5 wt % of the composition.

10 . The composition according to claim 1 , wherein the composition has a positive zeta potential at pH below 6.5.

11 . The composition according to claim 1 , wherein the composition further comprises a cationic surfactant.

12 . The composition according to claim 1 , wherein the composition further comprises a polymeric binder.

13 . The composition according to claim 5 , wherein the film has low friction coefficient of between 0.1 to 0.7.

14 . The composition according to claim 13 , wherein the low friction is maintained after annealing.

15 . A method of coating a metal substrate with the composition according to claim 1 , wherein the method comprises electrophoretic deposition plasma spray, ion beam coating, e-beam evaporation, thermal deposition, physical vapor deposition (PVD), aerosol deposition, vacuum deposition, sol gel deposition, or dip coating.

16 . The method according to claim 15 , wherein the metal substrate is biocompatible.

17 . The method according to claim 16 , wherein the metal substrate is titanium, alloys of titanium, Co—Cr alloys, magnesium, stainless steel, shape memory alloys of nickel-titanium, silver, tantalum, zirconium and novel ceramics or any electrical-conductive substrate.

18 . The method according to claim 15 , wherein the metal substrate is anodized prior to the electrophoretic deposition.

19 . The method according to claim 15 wherein the electrophoretic deposition is conducted between 2 to 5 hours.

20 . A dental or orthopedic implant comprising the composition according to claim 1 .

21 . A dental or orthopedic implant comprising a film on a biocompatible substrate, wherein the film comprises the composition according to claim 1 .

22 . A bone regeneration therapy comprising administering an artificial bone implant comprising the composition according to claim 1 .

23 . A method of osseointegration comprising contacting an artificial bone implant comprising the composition according to claim 1 in a bone needs to be improved.

24 . The method according to claim 23 , wherein the artificial bone implant comprises a biocompatible substrate coated by a film, wherein the film comprises said composition.

25 . The bone regeneration therapy according to claim 22 , wherein the artificial bone implant comprises a biocompatible substrate coated by a film, wherein the film comprises said composition.

Assignees

• Yeda Res & Dev
• Holon Academic Institute Of Tech

Inventors

• Tenne Reshef
• SHALOM Hila
• Rapoport Lev

Classifications

• C01B25/32 Primary

  Phosphates of magnesium, calcium, strontium, or barium · CPC title

• C08K3/32

  Phosphorus-containing compounds · CPC title

• C08K2003/321

  Phosphates · CPC title

• C25D11/26

  of refractory metals or alloys based thereon · CPC title

• A61L27/06

  Titanium or titanium alloys · CPC title