Compositions comprising sorbitan carboxylic esters and glycerol carboxylic esters

Patent metadata

Field	Value
Publication number	US-2020375862-A1
Application number	US-202016857523-A
Country	US
Kind code	A1
Filing date	Apr 24, 2020
Priority date	May 28, 2019
Publication date	Dec 3, 2020
Grant date	—

Abstract

The invention relates to compositions comprising certain sorbitan carboxylic esters and glycerol carboxylic esters in particular amounts.

First claim

1 . A composition comprising
A) at least one sorbitan carboxylic ester of at least one carboxylic acid selected from carboxylic acids having 6 to 12, carbon atoms, wherein all sorbitan carboxylic esters present in A) together have on average a degree of esterification of 0.7 to 2.1, carboxylic acid radicals per sorbitan carboxylic ester, B) at least one glycerol carboxylic ester of at least one carboxylic acid selected from carboxylic acids having 6 to 22, carbon atoms, wherein all glycerol carboxylic esters present in component B together have on average a degree of esterification of 0.7 to 1.5 carboxylic acid radicals per glycerol carboxylic ester, and C) water,
wherein components A) and B) in sum total are present to an extent of at least 50% by weight, preferably to an extent of at least 65% by weight, based on the total composition.

2 . The composition according to claim 1 , wherein A) has a saponification number of 100 to 300 mg KOH/g.

3 . The composition according to claim 1 , wherein B) has a saponification number of 100 to 300 mg KOH/g.

4 . The composition according to claim 1 , wherein said composition comprises
from 20 to 75 parts by weight of A), from 20 to 75 parts by weight of B), and from 0.01 to 50 parts by weight of water.

5 . The composition according to claim 1 , wherein B) comprises at least 70% by weight of glycerol monocarboxylic ester, wherein the percentages by weight refer to all glycerol carboxylic esters of B).

6 . The composition according to claim 1 , wherein the carboxylic acids of the carboxylic esters of components A) and B) are selected from fatty acids.

7 . The composition according to claim 1 , wherein the carboxylic acid of the sorbitan carboxylic ester of A) is selected from caprylic acid and capric acid.

8 . The composition according to claim 1 , wherein the carboxylic acid of the glycerol carboxylic ester of B) is selected from unsaturated or branched fatty acids.

9 . A process for preparing a cosmetic or pharmaceutical formulation, in particular having a viscosity of 500 to 15,000 mPa s, measured at 25° C. with a Brookfield viscometer using spindle 62 and at 30 rpm, comprising the process steps of
I) providing a composition according to claim 1 ,
II) mixing the composition with further cosmetic or pharmaceutical formulation constituents to obtain a formulation having a content of component A) and component B) in sum total in a range of 0.1% by weight to 5.0% by weight, wherein the percentages by weight refer to the total formulation.

10 . The process according to claim 9 , wherein in process step II) a water content is set in a range of 50% by weight to 95% by weight, wherein the percentages by weight refer to the total formulation.

11 . The process according to claim 9 comprising the process step of
III) adjusting the pH to a range of 4.0 to 8.0.

12 . A composition for increasing the viscosity of a cosmetic or pharmaceutical formulation comprising the composition according to claim 1 .

13 . The composition according to claim 1 , wherein
A) has at least one sorbitan carboxylic ester of at least one carboxylic acid selected from carboxylic acids having 8 to 10, carbon atoms and wherein all sorbitan carboxylic esters present in A) together have on average a degree of esterification of 1.3 to 1.7 carboxylic acid radicals per sorbitan carboxylic ester, B) at least one glycerol carboxylic ester of at least one carboxylic acid selected from carboxylic acids having 12 to 18 carbon atoms, wherein A) and B) in sum total are present to an extent of at least 75% by weight based on the total composition.

14 . The composition according to claim 1 , wherein A) has a saponification number of 160 to 260 mg KOH/g.

15 . The composition according to claim 1 , wherein B) has a saponification number of 130 to 230 mg KOH/g.

16 . The composition according to claim 1 , wherein B) comprises at least 80% by weight of glycerol monocarboxylic ester, wherein the percentages by weight refer to all glycerol carboxylic esters of B)

17 . The composition according to claim 1 , wherein the carboxylic acid of the sorbitan carboxylic ester of A) is a mixture of caprylic acid and capric acid.

18 . The composition according to claim 1 , wherein the carboxylic acid of the sorbitan carboxylic ester of A) is a mixture of caprylic acid and capric acid, with a ratio by weight of caprylic acid to capric acid in a range from 6:1 to 2:1.

19 . The composition according to claim 1 , wherein the carboxylic acid of the glycerol carboxylic ester of B) is oleic acid.

20 . The process according to claim 9 , wherein mixing the composition with further cosmetic or pharmaceutical formulation constituents to obtain a formulation having a content of component A) and component B) in sum total in a range of 0.2% by weight to 2.5% by weight wherein the percentages by weight refer to the total formulation.

Assignees

• Evonik Operations Gmbh

Inventors

• Brandt Kathrin Daniela
• Schuch Dominik
• Bednorz Beata

Classifications

• A61K2800/592

  Mixtures of compounds complementing their respective functions · CPC title

• A61K47/22

  Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones · CPC title

• A61K8/498

  having 6-membered rings or their condensed derivatives, e.g. coumarin · CPC title

• A61K47/14

  Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters · CPC title

• A61K8/4973 Primary

  with oxygen as the only hetero atom · CPC title