Hydrophilic Polymer Compositions

Patent metadata

Field	Value
Publication number	US-2020354546-A1
Application number	US-202016870554-A
Country	US
Kind code	A1
Filing date	May 8, 2020
Priority date	May 8, 2019
Publication date	Nov 12, 2020
Grant date	—

Abstract

The present disclosure relates to methods for preparing a hydrophilic composition including intimately mixing a silicone component including at least one polysiloxane and a polymer component, and to hydrophobic polymer compositions prepared thereby. One aspect of the disclosure provides an article having a major exterior surface, the article comprising an intimate mixture of a silicone component including at least one polysiloxane; and a polymer component including at least one hydrophilic polymer having a water-absorption capacity of at least 50 wt. %; wherein the silicone component and the polymer component are present in the mixture in a dry weight ratio within the range of 99.9:0.1 to 30:70. In certain desirable embodiments as otherwise described herein, the intimate mixture is disposed at an exterior surface of the article, e.g., at the major exterior surface of the article.

First claim

We claim:

1 . An article having a major exterior surface, the article comprising an intimate mixture of
a silicone component including at least one polysiloxane; and a polymer component including at least one hydrophilic polymer having a water-absorption capacity of at least 50 wt. %;
wherein the silicone component and the polymer component are present in the mixture in a dry weight ratio within the range of 99.9:0.1 to 30:70.

2 . The article of claim 1 , wherein the intimate mixture is disposed at the major exterior surface of the article.

3 . The article of claim 1 , wherein the silicone component comprises the cured product of a curable composition including one or more cross-linkable polysiloxanes and an effective amount of a cross-linking agent.

4 . The article of claim 3 , wherein the curable composition includes
a first polysiloxane having at least about one silicon hydride group (e.g., at least about two silicon hydride groups), present in the curable composition in an amount within the range of 0.05 wt. % to 40 wt. % (e.g., 0.1 wt. % to 20 wt. %); a second polysiloxane having at least about one alkenyl group (e.g., at least about two alkenyl groups), present in the curable composition in an amount within the range of 2 wt. % to 99.95 wt. % (e.g., 20 wt. % to 99.9 wt. %); and an effective amount of a hydrosilylation catalyst, present in the silicone component, for example, in an amount within the range of 0.0001 wt. % to 1 wt. % (e.g., 0.0001 wt. % to 0.2 wt. %).

5 . The article of claim 3 , wherein the curable composition includes
a first polysiloxane having at least about one silicon hydride group (e.g., at least about two silicon hydride groups), present in the silicone component in an amount within the range of 0.1 wt. % to 80 wt. % (e.g., 1 wt. % to 60 wt. %); a second polysiloxane having at least about one alkenyl group (e.g., at least about two alkenyl groups), present in the silicone component in an amount within the range of 2 wt. % to 99.9 wt. % (e.g., 20 wt. % to 99.9 wt. %); and an effective amount of a hydrosilylation catalyst, present in the silicone component, for example, in an amount within the range of 0.0001 wt. % to 1 wt. % (e.g., 0.0001 wt. % to 0.2 wt. %).

6 . The article of claim 3 , wherein one or more polysiloxanes of the curable composition comprises at least about one reactive heterocycloalkyl group.

7 . The article of claim 1 , wherein the silicone component further comprises a filler selected from ceramic particles, glass particles, metallic particles, polymeric particles, or any combination thereof, present in the silicone component in an amount within the range of 1 wt. % to 70 wt. %.

8 . The article of claim 1 , wherein the polymer component comprises a hydrophilic polymer having a water-absorption capacity of at least 75 wt. %.

9 . The article of claim 1 , wherein the polymer component comprises a polyvinyl alcohol or a polyvinyl pyrrolidone.

10 . The article of claim 1 , wherein the polymer component comprises one or more saccharides (e.g., one or more oligosaccharides and/or polysaccharides).

11 . The article of claim 10 , wherein the polymer component comprises one or more ionic polysaccharides.

12 . The article of claim 10 , wherein the polymer component comprises one or more polysaccharides selected from starch, alginate, cellulose, hyaluronic acid, chitin, and derivatives thereof.

13 . The article of claim 10 , wherein the polymer component comprises one or more ionically cross-linked polysaccharides (e.g., a Ca 2+ -cross-linked polysaccharide).

14 . The article of claim 1 , wherein one or more polysiloxanes of the silicone component is cross-linked via covalent bonding to a hydrophilic polymer of the polymer component.

15 . The article of claim 1 , wherein the intimate mixture further comprises a liquid having a cellulose-swelling capacity of at least 20 wt. %.

16 . The article of claim 1 , wherein the intimate mixture further comprises water.

17 . The article of claim 16 , wherein the weight ratio of the combined amount of hydrophilic polymers to water in the intimate mixture is within the range of 10:90 to 95:5.

18 . The article of claim 16 , wherein an exterior surface of the article comprises a hydrogel formed from the water and the one or more hydrophilic polymers.

19 . The article of claim 1 , wherein the intimate mixture further comprises a polar organic solvent selected from methanol, ethanol, acetone, or acetonitrile.

20 . The article of claim 1 , wherein one or more hydrophilic polymers of the polymer component comprises a plurality of buffering functional groups.

21 . The article of claim 1 , wherein the exterior surface further comprises one or more active components selected from pharmaceutical compounds, proteins, peptides, cells, or a mixture thereof.

22 . The article of claim 1 , wherein the intimate mixture is formed as a layer on a substrate.

23 . The article of claim 1 , in the form of a tubular article.

24 . The article of claim 1 , in the form of a catheter, wound dressing or beverage tube.

25 . A method for preparing a hydrophilic polymer composition, the method comprising intimately mixing
a silicone component including at least one polysiloxane; and a polymer component including at least one hydrophilic polymer having a water-absorption capacity of at least 50 wt. %;
wherein the silicone component and the polymer component are present in the composition in a dry weight ratio within the range of 99.9:0.1 to 30:70.

Assignees

• Saint Gobain Performance Plastics Corp

Inventors

• Zhang Jianfeng
• Ding Jian L
• Lu Guangyu
• Pytel Rachel

Classifications

• C08L83/04 Primary

  Polysiloxanes · CPC title

• C08L1/286 Primary

  substituted with acid radicals, e.g. carboxymethyl cellulose [CMC] (C08L1/282 takes precedence) · CPC title

• C08J2483/04

  Polysiloxanes · CPC title

• C08J2405/08

  Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof · CPC title

• C08J2405/04

  Alginic acid; Derivatives thereof · CPC title