Pharmaceutical packages with coatings comprising polysilazane

Patent metadata

Field	Value
Publication number	US-2020346970-A1
Application number	US-202016858166-A
Country	US
Kind code	A1
Filing date	Apr 24, 2020
Priority date	May 1, 2019
Publication date	Nov 5, 2020
Grant date	—

Abstract

The present disclosure is directed to pharmaceutical packages that include a coating that comprises polysilazane, and methods for the production of such. In one or more embodiments of the present disclosure, a pharmaceutical package may include a glass container comprising a first surface and a second surface opposite the first surface. The first surface may be an outer surface of the glass container. The pharmaceutical package may further include a coating positioned over at least a portion of the first surface of the glass container. The coating may include polysilazane.

First claim

What is claimed is:

1 . A pharmaceutical package comprising:
a glass container comprising a first surface and a second surface opposite the first surface, wherein the first surface is an outer surface of the glass container; and a coating positioned over at least a portion of the first surface of the glass container, the coating comprising one or more polysilazanes.

2 . The pharmaceutical package of claim 1 , wherein one or more of the polysilazanes comprise an organic moiety.

3 . The pharmaceutical package of claim 1 , wherein the coating comprises at least 15 wt. % of the one or more polysilazanes.

4 . The pharmaceutical package of claim 1 , wherein at least a portion of the coating comprises at least 5 atm. % nitrogen.

5 . The pharmaceutical package of claim 3 , wherein at least a portion of the coating comprises at least 5 atm. % nitrogen.

6 . The pharmaceutical package of claim 1 , wherein the coating further comprises polysilane.

7 . The pharmaceutical package of claim 1 , wherein the coating further comprises polysiloxane.

8 . The pharmaceutical package of claim 3 , wherein the coating further comprises polysilane and polysiloxane.

9 . The pharmaceutical package of claim 1 , wherein the coating has a thickness of 1 micron or less.

10 . The pharmaceutical package of claim 9 , wherein the coating is in direct contact with at least a portion of the first surface of the glass container.

11 . The pharmaceutical package of claim 1 , wherein the portion of the first surface of the glass container with the coating has a coefficient of friction of less than or equal to about 0.7.

12 . The pharmaceutical package of claim 3 , wherein the portion of the first surface of the glass container with the coating retains a coefficient of friction of less than or equal to about 0.7 following a heat treatment at a temperature of at least about 250° C. for 30 minutes.

13 . The pharmaceutical package of claim 3 , wherein a light transmission through the pharmaceutical package is greater than or equal to about 55% of a light transmission through an uncoated pharmaceutical package for each wavelength from about 400 nm to about 700 nm.

14 . The pharmaceutical package of claim 1 , wherein the pharmaceutical package retains a light transmission through the pharmaceutical package of greater than or equal to about 55% of the light transmission through the uncoated pharmaceutical package for each wavelength from about 400 nm to about 700 nm following a heat treatment at a temperature of at least about 250° C. for 30 minutes.

15 . A pharmaceutical package comprising:
a glass container comprising a first surface and a second surface opposite the first surface, wherein the first surface is an outer surface of the glass container; and a coating positioned over at least a portion of the first surface of the glass container, the coating formed from silazane monomeric units or prepolymers comprising silazane monomeric units.

16 . The pharmaceutical package of claim 15 , wherein one or more of the silazane monomeric units or prepolymers comprising silazane monomeric units comprise organic moieties.

17 . The pharmaceutical package of claim 15 , wherein the coating comprises at least 50 wt. % of the one or more polysilazanes.

18 . A method producing a coated pharmaceutical package, the method comprising:
depositing a coating precursor mixture onto a first surface of an outer surface of a glass container, the coating precursor mixture comprising one or more silazane monomeric units or prepolymers comprising silazane monomeric units; and heating the coating precursor mixture to form a coating on the outer surface of the glass container, the coating comprising one or more polysilazanes.

19 . The method of claim 18 , wherein the heating of the coating precursor mixture is in dry heat.

20 . The method of claim 18 , wherein the one or more polysilazanes comprise an organic moiety.

21 . The method of claim 18 , wherein the coating comprises at least 15 wt. % of the one or more polysilazanes.

Assignees

• Corning Inc

Inventors

• Arliguie Therese Francoise
• Deng Huayun
• Hayes Richard Allen
• Mccarthy Kevin Robert
• Niu Weijun
• Wagner Frederic Christian

Classifications

• C03C2217/78

  Coatings specially designed to be durable, e.g. scratch-resistant · CPC title

• C03C17/30 Primary

  with silicon-containing compounds · CPC title

• C03C17/005 Primary

  Coating the outside · CPC title

• B65D23/0821

  consisting mainly of polymeric materials (B65D23/0828 takes precedence) · CPC title

• B65D1/0215

  multilayered (B65D81/3837 takes precedence) · CPC title