Umbilical cord mesenchymal stem cell exosomes
US-2015125950-A1 · May 7, 2015 · US
US2020338136A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2020338136-A1 |
| Application number | US-201916959175-A |
| Country | US |
| Kind code | A1 |
| Filing date | Jan 7, 2019 |
| Priority date | Jan 5, 2018 |
| Publication date | Oct 29, 2020 |
| Grant date | — |
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The present invention may provide a pharmaceutical composition for preventing or treating skin diseases, a cosmetic composition for preventing or improving skin diseases, and a stem cell therapeutic agent, which comprise an induced pluripotent stem cell-derived mesenchymal stem cell (iMSC), a culture thereof, or an exosome isolated from an iMSC or iMSC culture as active ingredients. When the composition of the present invention, etc. is used, it is possible to provide a composition for improving, preventing or treating skin diseases and a stem cell therapeutic agent which have an improved immunomodulating function over conventional mesenchymal stem cells.
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1 .- 4 . (canceled) 5 . An exosome isolated from induced pluripotent stem cell-derived mesenchymal stem cells or a culture thereof. 6 .- 9 . (canceled) 10 . A composition comprising one or more exosomes of claim 5 . 11 . A method for treating or alleviating a skin disease in a subject in need thereof, comprising: administering to the subject a composition comprising one or more induced pluripotent stem cell (iPSC)-derived mesenchymal stem cells (iMSC) or a culture thereof 12 . The method of claim 11 , wherein the skin disease is selected from the group consisting of atopic dermatitis, contact dermatitis, and psoriasis. 13 . The method of claim 11 , wherein the subject is a mammal or a human. 14 . A method for treating or alleviating a skin disease in a subject in need thereof, comprising: administering to the subject a composition comprising one or more exosomes isolated from induced pluripotent stem cell-derived mesenchymal stem cells or a culture thereof. 15 . The method of claim 14 , wherein the skin disease is selected from the group consisting of atopic dermatitis, contact dermatitis, and psoriasis. 16 . The method of claim 14 , wherein the subject is a mammal or a human.
from microorganisms other than algae or fungi, e.g. protozoa or bacteria · CPC title
Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells · CPC title
Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells · CPC title
Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant · CPC title
of mammals or bird · CPC title
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