Composition for improving or preventing nonalcoholic fatty liver

Patent metadata

Field	Value
Publication number	US-2020289605-A1
Application number	US-202016889367-A
Country	US
Kind code	A1
Filing date	Jun 1, 2020
Priority date	Mar 3, 2015
Publication date	Sep 17, 2020
Grant date	—

Abstract

An object of the present invention is to provide a composition for preventing or improving fat deposition on the liver in spite of the alcohol intake history of a level that a liver disease is not caused. The inventors found that glutathione has an effect of preventing or improving fat deposition on the liver, which is not caused by alcohol, and completed the present invention. Among nonalcoholic fat diseases, the present invention is particularly effective in an early stage of the treatment or in a case where treatment for another disease is not performed.

First claim

1 . A method for improving or preventing a nonalcoholic fatty liver disease, comprising administering to a patient in need of treatment for nonalcoholic fatty liver disease a composition comprising glutathione as an active ingredient, wherein the nonalcoholic fatty liver disease is a disease having low liver stiffness, and the disease having low liver stiffness is a disease corresponding to any one of the following:
(1) Measurement value of Type IV collagen 7S domain in the serum is 4.5 ng/ml or less, or (2) Measurement value with a device in which the principle is transient elastography that measures the propagation velocity of pulse oscillatory wave in the tissue with elasticity (kPa) by an ultrasonic pictorial analysis method as a noninvasive examination, is 9.0 kPa or less.

Assignees

• Kohjin Life Sciences Co Ltd
• Public Univ Corp Yokohama City Univ
• Kyoto Prefectural Public Univ Corp
• Univ Saga

Inventors

• Kessoku Takaomi
• Nakajima Atsushi
• Sumida Yoshio
• Eguchi Yuichiro
• Saito Susumu
• Sauchi Yusuke

Classifications

• A61P1/16

  for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics · CPC title

• A61K38/06

  Tripeptides · CPC title

• A61K38/00

  Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00) · CPC title

• A61K38/063 Primary

  Glutathione · CPC title

• A61K38/03 Primary

  Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof · CPC title