CONTOUR ELECTROCORTICOGRAPHY (ECoG) ARRAY

Patent metadata

Field	Value
Publication number	US-2020289002-A1
Application number	US-202016809778-A
Country	US
Kind code	A1
Filing date	Mar 5, 2020
Priority date	Mar 15, 2019
Publication date	Sep 17, 2020
Grant date	—

Abstract

ElectroCorticoGraphy (ECoG) sensors and uses are disclosed. These ECoG arrays, systems, and processes may be operable or configured to: i) simultaneously record neural signals while providing stimulation on specific portions of the cortex using a user-guided stimulator; ii) acquire neural signals over a large cortex area; iii) provide individual or group stimulation while concurrently receiving neural feedback; and/or iv) acquire neural signals at a setting remote from the neural source using wireless or other communication techniques.

First claim

What is claimed is:

1 . A real-time neural electrocorticography (ECoG) measurement system comprising:
a flexible two-dimensional substrate, the substrate comprising a plurality of tines with each tine comprising a plurality of sensors,
wherein each tine has an arc of curvature, the arc of curvature being at least nineteen centimeters in length,
wherein the substrate comprises a biocompatible material,
wherein an open spacing exists between adjacent tines of the plurality of tines;
a wired connector connected to an output of the plurality of sensors; and a wireless transceiver in communication with the wired connector,
wherein each sensor electrode of the plurality of sensors has a mass of 3.0 mg to 98 mg, and
wherein the transceiver has circuit topology configured to send neural signals received from the sensors to a system monitor.

2 . The system of claim 1 wherein circuit topology of the transceiver is configured to provide contemporaneous reporting of neural signals received from the sensors when external stimulation is provided between sensors of the plurality of sensors.

3 . The system of claim 1 wherein the system monitor is configured to receive the contemporaneous neural signals from the transceiver and to record the received contemporaneous neural signals.

4 . The system of claim 1 wherein the substrate is coated with no more than 0.8 mm of medical grade silicone.

5 . The system of claim 1 wherein the substrate comprises no more than 0.8 mm of medical grade silicone.

6 . The system of claim 1 wherein the flexible two-dimensional substrate is in the shape of a trident.

7 . The system of claim 1 wherein the sensors are equidistantly spaced along tines of the substrate.

8 . A neural sensor comprising:
a first one-dimensional array of sensors, wherein at least one sensor in the first array has a mass of 98 mg; a second one-dimensional array of sensors, wherein at least sensor in the second array has a mass of 98 mg; a silicone substrate supporting the first array and the second array, the silicone substrate having a thickness of no greater than 0.8 mm and having a void spacing between the first array and the second array; and a communication circuit, the communication circuit tethered to a node, the node electrically connected to the first array or the second array or both.

9 . The neural sensor of claim 8 wherein sensors of the first array are circular and are spaced apart from each other at least by their average circumference.

10 . The neural sensor of claim 8 wherein the first array and the second array are positioned on tines of a triton and wherein the spacing between the first array and the second array is at least 2.0 mm.

11 . The neural sensor of claim 8 wherein the node is coupled to a transceiver, the transceiver configured to provide contemporaneous reporting of neural signals received from the sensors when external stimulation is provided between sensors of the first one-dimensional array and the second one-dimensional array.

12 . The neural sensor of claim 8 wherein the first one-dimensional array and the second one-dimensional array are parallel to each other.

13 . The neural sensor of claim 11 wherein the transceiver is configured with an antenna and the transceiver is configured to wirelessly communicate with a system monitor.

14 . A real-time neural electrocorticography (ECoG) measurement system comprising:
a flexible two-dimensional substrate, the substrate comprising a plurality of arrays with each array comprising a plurality of electrodes,
wherein each array has a radius of curvature, the radius of curvature being at least nineteen centimeters in length,
wherein the substrate comprises a biocompatible material,
wherein an open spacing exists between adjacent arrays of the plurality of arrays;
a wired connector connected to an output of the plurality of electrodes; and a wireless transceiver in communication with the wired connector,
wherein each electrode of the plurality of electrodes has a mass of 3.0 mg to 98 mg, and
wherein the transceiver has circuit topology configured to send neural signals received from the electrodes to a system monitor.

15 . The system of claim 14 wherein the arrays are one-dimensional arrays.

16 . The system of claim 14 wherein circuit topology of the transceiver is configured to provide contemporaneous reporting of neural signals received from the sensors when external stimulation is provided between electrodes of the plurality of electrodes.

17 . The system of claim 14 wherein the system monitor is configured to receive the contemporaneous neural signals from the transceiver and to record the received contemporaneous neural signals.

18 . The system of claim 14 wherein the substrate comprises no more than 0.8 mm of medical grade silicone.

19 . The system of claim 14 wherein the flexible two-dimensional substrate is in the shape of a polygon.

20 . The system of claim 14 wherein the sensors are equidistantly spaced along one-dimensional arrays of the substrate.

Assignees

• Univ Arizona State
• Mayo Found Medical Education & Res

Inventors

• Chae Junseok
• Liu Shiyi
• Quinones-Hinojosa Alfredo
• Vivas-Buitrago Tito

Classifications

• A61B5/37 Primary

  Intracranial electroencephalography [IC-EEG], e.g. electrocorticography [ECoG] · CPC title

• A61B5/375

  using biofeedback · CPC title

• A61B5/24

  Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof · CPC title

• A61N1/0531

  Brain cortex electrodes · CPC title

• A61B5/6868

  Brain · CPC title