System and method for local electrophysiological characterization of cardiac substrate using multi-electrode catheter

Patent metadata

Field	Value
Publication number	US-2020253496-A1
Application number	US-201916593631-A
Country	US
Kind code	A1
Filing date	Oct 4, 2019
Priority date	Feb 25, 2014
Publication date	Aug 13, 2020
Grant date	—

Abstract

A system for determining electrophysiological data comprising an electronic control unit configured to acquire electrophysiology signals from a plurality of electrodes ( 130 ) of one or more catheters, select at least one clique of electrodes from the plurality of electrodes ( 136 ) to determine a plurality of local E field data points, determine the location and orientation of the plurality of electrodes, process the electrophysiology signals from the at least one clique from a full set of bipole subcliques to derive the local E field data points associated with the at least one clique of electrodes, derive at least one orientation independent signal from the at least one clique of electrodes ( 138 ) from the information content corresponding to weighted parts of electrogram signals, and display or output catheter orientation independent electrophysiologic information to a user or process.

First claim

1 .- 20 . (canceled)

21 . A system for determining electrophysiological data comprising:
an electronic control unit configured to: acquire electrophysiology signals from a plurality of electrodes of one or more catheters; select at least one clique of electrodes from the plurality of electrodes to determine a plurality of local E field data points; process the electrophysiology signals from the at least one clique to derive the local E field data points associated with the at least one clique of electrodes; derive at least one orientation independent signal from the at least one clique of electrodes; and output catheter orientation independent electrophysiologic information to a user or process.

22 . The system according to claim 21 , wherein the electronic control unit is further configured to determine the location and orientation of the plurality of electrodes.

23 . The system according to claim 22 , wherein the electronic control unit is further configured to use at least one criteria to determine whether each at least one clique is in contact with a target surface.

24 . The system according to claim 23 , wherein the at least one criteria comprises at least one of an angular deviation, a distance between the at least one clique and a target surface, and the characteristics of E t and E a from a clique.

25 . The system according to claim 23 , wherein the at least one criteria comprises an amplitude of a unipolar signal obtained from each of the electrodes in a clique and the morphology of unipolar signals obtained from the electrodes in a clique.

26 . The system according to claim 23 , wherein the electronic control unit is configured to receive one or more criteria from a user or process to determine whether each at least one clique is in contact with the target surface.

27 . The system according to claim 21 , wherein the electronic control unit is further configured to:
weight the E field data points; and derive the orientation independent electrophysiologic information from the weighted E field data points.

28 . The system according to claim 27 , wherein the electronic control unit is configured to derive at least one of a substrate voltage amplitude, local activation timing, or conduction velocity from the weighted E field data points.

29 . The system according to claim 27 , wherein the plurality of E field data points form an E field loop, and wherein the electronic control unit is further configured to weight each of the E field data points based on the distance of a point in the E field from an isoelectric origin.

30 . The system according to claim 27 , wherein the plurality of E field data points form an E field loop, and wherein the electronic control unit is further configured to weight the data points in the E-field loop based on |d/dt(E(t))|.

31 . The system according to claim 27 , wherein the plurality of E field data points form an E field loop, and wherein the weight of the E field data points is determined from a weighting function that increases the weight in a region corresponding to the zero-crossing of Ea.

32 . The system according to claim 21 , wherein the at least one clique of electrodes comprises a plurality of adjacent cliques.

33 . The system according to claim 32 , wherein the electronic control unit is further configured to compute a local velocity vector for each of the plurality of adjacent cliques.

34 . The system according to claim 33 , wherein the electronic control unit is further configured to determine a divergence and curl path integral and a path length.

35 . The system according to claim 33 , wherein the electronic control unit is further configured to determine whether a uniform propagation, a rotor, a focal source, a collision site, or a scar is present within the plurality of adjacent cliques.

36 . The system according to claim 35 , wherein the electronic control unit is further configured to score each of the plurality of adjacent cliques.

37 . The system according to claim 35 , wherein the electronic control unit is further configured to compare the score of each of the plurality of adjacent cliques to at least one template.

38 . The system according to claim 32 , wherein the electronic control unit is configured to calculate a score for a target clique from at least one clique adjacent to the target clique.

39 . The system according to claim 21 , wherein the catheter orientation independent electrophysiologic information output by the electronic control unit is b eat-by-beat information.

40 . A method for determining electrophysiological data comprising:
acquiring electrophysiology signals from a plurality of electrodes of one or more catheters; selecting at least one clique of electrodes from the plurality of electrodes to determine a plurality of local E field data points; processing the electrophysiology signals from the at least one clique to derive the local E field data points associated with the at least one clique of electrodes; deriving at least one orientation independent signal from the at least one clique of electrodes; and outputting catheter orientation independent electrophysiologic information to a user or process.

Assignees

• St Jude Medical Cardiology Div

Inventors

• Deno D Curtis
• Balachandran Ram K

Classifications

• A61B5/367

  Electrophysiological study [EPS], e.g. electrical activation mapping or electro-anatomical mapping · CPC title

• A61B5/339

  Displays specially adapted therefor · CPC title

• A61B5/341

  Vectorcardiography [VCG] · CPC title

• A61B5/287 Primary

  Holders for multiple electrodes, e.g. electrode catheters for electrophysiological study [EPS] · CPC title

• A61B5/6852 Primary

  Catheters · CPC title