Cell transplant device and method of manufacturing the same

Patent metadata

Field	Value
Publication number	US-2020246760-A1
Application number	US-202016805075-A
Country	US
Kind code	A1
Filing date	Feb 28, 2020
Priority date	Aug 30, 2017
Publication date	Aug 6, 2020
Grant date	—

Abstract

An object of the present invention is to provide a cell transplant device having an ability to induce angiogenesis around the cell transplant device, and a method for manufacturing the same. According to the present invention, a cell transplant device including a cell structure (A) that includes a plurality of biocompatible polymer blocks and a plurality of cells of at least one type, and in which at least one of the biocompatible polymer blocks is disposed in gaps between the plurality of cells; and an immunoisolation membrane (B) that encloses the cell structure is provided.

First claim

What is claimed is:

1 . A method for cell transplantation, which comprises transplanting, to a subject in need of angiogenesis, a cell transplant device including a cell structure (A) that has a plurality of biocompatible polymer blocks and a plurality of cells of at least one type, and in which at least one of the biocompatible polymer blocks is disposed in gaps between the plurality of cells; and an immunoisolation membrane (B) that encloses the cell structure.

2 . The method according to claim 1 , wherein a size of one of the biocompatible polymer blocks is 20 μm to 200 μm.

3 . The method according to claim 1 , wherein a biocompatible polymer in the biocompatible polymer block is cross-linked by heat, ultraviolet rays, or an enzyme.

4 . The method according to claim 1 , wherein the biocompatible polymer block is amorphous.

5 . The method according to claim 1 , wherein the cell structure includes 0.0000001 μg to 1 μg of biocompatible polymer blocks per cell.

6 . The method according to claim 1 , wherein the immunoisolation membrane is a porous membrane including a polymer.

7 . The method according to claim 6 , wherein a minimum pore diameter of the porous membrane is 0.02 μm to 1.5 μm.

8 . The method according to claim 6 , wherein a thickness of the porous membrane is 10 μm to 250 μm.

9 . The method according to claim 6 , wherein, within an inner side of the porous membrane, a layered compact portion in which a pore diameter is minimized is present, and a pore diameter continuously increases in a thickness direction from the compact portion toward at least one surface of the porous membrane.

10 . The method according to claim 9 , wherein a thickness of the compact portion is 0.5 μm to 30 μm.

11 . The method according to claim 6 , wherein a ratio of a maximum pore diameter to a minimum pore diameter of the porous membrane is 3.0 to 20.0.

12 . The method according to claim 6 , wherein the porous membrane contains at least one kind of polysulfone and polyvinylpyrrolidone.

Assignees

• Fujifilm Corp

Inventors

• Nakamura Kentaro
• KOGAWA Ryo
• Mochizuki Yusuke
• Takegami Ryuta

Classifications

• B01D71/441

  Polyvinylpyrrolidone · CPC title

• A61L2400/12

  Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces · CPC title

• A61L27/50

  Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials} · CPC title

• A61L27/26

  Mixtures of macromolecular compounds · CPC title

• A61L27/222

  Gelatin · CPC title