Pyridazinedione-based heterobicyclic covalent linkers and methods and applications thereof
US-2024425465-A1 · Dec 26, 2024 · US
US2020239484A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2020239484-A1 |
| Application number | US-202016847394-A |
| Country | US |
| Kind code | A1 |
| Filing date | Apr 13, 2020 |
| Priority date | Feb 5, 2016 |
| Publication date | Jul 30, 2020 |
| Grant date | — |
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The present invention relates to a method for preparing a pyrrolo[3,2-d]pyrimidine compound (the compound represented by formula I), and corresponding intermediates.
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1 . A compound of formula VI: wherein R 1 and R 2 are independently selected from the group consisting of C 1-4 alkyl, or R 1 and R 2 together with the N atom attached thereto form 4-8 membered heterocycloalkyl, wherein the heterocycloalkyl is optionally substituted with one or more substituents independently selected from hydroxyl, halogen, C 1-4 alkyl and C 1-4 alkoxy. 2 . The compound of formula VI according to claim 1 , wherein R 1 and R 2 are independently selected from the group consisting of C 1-4 alkyl. 3 . The compound of formula VI according to claim 1 , wherein R 1 and R 2 together with the N atom attached thereto form 4-8 membered heterocycloalkyl, wherein the heterocycloalkyl is optionally substituted with one or more substituents independently selected from hydroxyl, halogen, C 1-4 alkyl and C 1-4 alkoxy. 4 . The compound of formula VI according to claim 1 , wherein NR 1 R 2 of formula VI is selected from the group consisting of 5 . The compound of formula VI according to claim 1 , selected from:
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 · CPC title
Ortho-condensed systems · CPC title
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