Delivery system

Patent metadata

Field	Value
Publication number	US-2020238024-A1
Application number	US-201916696738-A
Country	US
Kind code	A1
Filing date	Nov 26, 2019
Priority date	Mar 7, 2011
Publication date	Jul 30, 2020
Grant date	—

Abstract

Provided herein is a delivery system, including: (a) an optical sensor configured to detect data to create a map of a patient bodily surface; and (b) a dispenser operatively associated with the optical sensor and configured to deliver compositions (optionally including cells) to the patient bodily surface based upon the data or map. Methods of forming a tissue on a patient bodily surface of a patient in need thereof are also provided, as are methods, systems and computer program products useful for processing patient bodily surface data.

First claim

1 .- 61 . (canceled)

62 . A delivery system comprising:
an optical detector comprising a three-dimensional scanner, wherein the optical detector is configured to perform detection of data to create a map of an area of interest of a patient; a depth detector operatively associated with the optical detector and configured to account for movement of the patient during the detection;
a dispenser operatively associated with the optical detector and configured to deliver cells and/or compositions to the area of interest based upon the data and/or the map;
a three-dimensional plotter operatively connected with the three-dimensional scanner; and
a controller operatively connected with the dispenser.

63 . The delivery system of claim 62 , wherein the depth detector comprises an infrared detector and/or a laser scanner.

64 . The delivery system of claim 63 , wherein the three-dimensional scanner is a hand-held laser scanner.

65 . The delivery system of claim 62 , wherein the dispenser comprises a plurality of nozzles.

66 . The delivery system of claim 65 , further comprising one or more cartridges loaded with the cells and/or compositions,
wherein the nozzles are in fluid communication with the one or more cartridges.

67 . The delivery system of claim 66 , wherein the nozzles are configured for pressure-based delivery of the cells and/or compositions.

68 . The delivery system of claim 66 , wherein the cells are selected from the group consisting of cartilage cells, bone cells, muscle cells, vascular cells, skin cells, and combinations thereof.

69 . The delivery system of claim 62 , wherein the area of interest is a closed wound.

70 . The delivery system of claim 62 , wherein the area of interest comprises an injury or disease of the patient.

71 . The delivery system of claim 62 , further comprising a computing system comprising:
a processor; and a memory coupled to the processor and comprising computer readable program code that when executed by the processor causes the processor to perform operations comprising:
interpreting the data from the optical detector to form the map of the area of interest;
transforming the map into a negative mold of the area of interest, wherein the mold comprises a plurality of Z-axis layers; and
overlaying each of the Z-axis layers with a series of lines, wherein the lines provide a path for the dispenser to deliver the cells and/or the compositions to the area of interest.

72 . The delivery system of claim 62 , further comprising a surgical device that is configured to provide the optical detector and/or the dispenser with access to the area of interest.

73 . The delivery system of claim 72 , wherein the surgical device is an endoscopic device.

74 . A computer program product for processing data of an area of interest of a patient that is obtained from a three-dimensional optical detector comprising a depth detector and a three-dimensional scanner to provide a path to a dispenser operatively coupled to the three-dimensional optical detector, the computer program product comprising a non-transitory computer readable medium having computer readable program code embodied therein, the computer readable program code comprising:
computer readable program code that interprets data that is provided by the optical detector to form a map of the area of interest of the patient; computer readable program code that transforms the map into a negative mold of the area of interest, wherein the mold comprises a plurality of Z-axis layers; computer readable program code that overlays each of the Z-axis layers with a series of lines, wherein the lines provide the path for the dispenser to deliver cells and/or compositions to the area of interest; and computer readable program code that adjusts the path for the dispenser based on movement of the patient that is detected by the depth detector.

75 . The computer program product of claim 74 , wherein the cells are selected from the group consisting of cartilage cells, bone cells, muscle cells, vascular cells, skin cells, and combinations thereof.

76 . The computer program product of claim 74 , wherein the area of interest is a closed wound.

77 . The computer program product of claim 74 , wherein the area of interest comprises an injury or disease of the patient.

78 . The computer program product of claim 74 , wherein the data from the optical detector is represented as an object including the Z-axis layers, and
wherein each of the Z-axis layers are represented by a grid that comprises the lines.

79 . The computer program product of claim 78 , wherein the computer readable program code is further configured to direct the dispenser to deliver the cells and/or the compositions to a first location of the area of interest that is associated with a first piece of the grid while analyzing a second piece of the grid.

80 . The computer program product of claim 78 , further comprising computer readable program code that parses the object in a manner that incorporates locations of different ones of the cells and/or the compositions to be delivered by the dispenser.

81 . The computer program product of claim 74 , wherein the computer readable program code is further configured to control a surgical device to provide the optical detector and/or the dispenser with access to the area of interest.

82 . The computer program product of claim 81 , wherein the surgical device is an endoscopic device.

83 . The computer program product of claim 74 , wherein the Z-axis layers correspond to one or more tissue layers.

84 . The computer program product of claim 74 , wherein the computer readable program code is further configured to calibrate the depth detector based on the area of interest and/or a body type of the patient.

85 . The computer program product of claim 74 , wherein the computer readable program code is further configured to control a three-dimensional plotter that is operatively associated with the optical detector to position the dispenser.

86 . A method of treating an area of interest of a patient, comprising:
scanning the area of interest with an optical detector to obtain three-dimensional coordinates thereof, wherein the optical detector comprises a three-dimensional scanner; processing the three-dimensional coordinates by:
interpreting data from the optical detector to form a map of the area of interest;
transforming the map into a negative mold of the area of interest, wherein the mold comprises a plurality of Z-axis layers; and
overlaying each of the Z-axis layers with a series of lines, wherein the lines provide a path for a dispenser to deliver cells and/or compositions to the area of interest; controlling the dispenser to deliver the cells and/or the compositions to the area of interest based on the path; and adjusting the path for the dispenser based on movement of the patient that is detected by a depth detector that is operatively associated with the optical detector.

87 . The method of claim 86 , wherein the cells are selected from the group consisting of cartilage cells, bone cells, muscle cells, vascular cells, skin cells, and combinations thereof.

88 . The method of claim 86 , wherein the area of interest is a closed wound.

89 . The method of claim 86 , wherein the area of i

Assignees

• Univ Wake Forest Health Sciences

Inventors

• Yoo James J
• Atala Anthony
• Binder Kyle W
• Albanna Mohammad Z
• Zhao Weixin
• Dice Dennis
• Xu Tao

Classifications

• A61B5/0064 Primary

  Body surface scanning · CPC title

• A61F2/02 Primary

  Prostheses implantable into the body · CPC title

• A61F2/10

  Hair or skin implants · CPC title

• A61M35/20

  Non-portable devices, e.g. spraying booths · CPC title

• A61B2017/3225

  with processing of harvested tissue · CPC title