Manufacturing method for granule

Patent metadata

Field	Value
Publication number	US-2020188302-A1
Application number	US-201916598299-A
Country	US
Kind code	A1
Filing date	Oct 10, 2019
Priority date	Apr 14, 2017
Publication date	Jun 18, 2020
Grant date	—

Abstract

The purpose of the present invention is to provide a method for producing granules of having a uniform size. To this end, the present invention provides a method for producing granules, the method characterized by including preparing an organic member solution, uniformly dispersing an inorganic member in the organic member solution at a weight ratio of 1 to 10 based on an organic member to form an organic-inorganic composite solution, spraying the organic-inorganic composite solution in an electrostatic charge manner, and polymerizing the sprayed organic-inorganic composite solution to form a hydrogel phase. The production method of the present invention has advantages in that granules having a uniform size may be mass-produced in a short time and the granules may be produced at a high yield. Accordingly, the production method of the present invention has advantages in that the method may be applied to a variety of fields, such as a pharmaceutical field, a medical field, a cosmetics field, and a food field and that the method may replace a conventional spray drying method.

First claim

1 . A method for manufacturing granules, the method comprising:
preparing an organic member solution; uniformly dispersing an inorganic member in the organic member solution at a weight ratio of 1 to 10 based on an organic member to form an organic-inorganic composite solution; spraying the organic-inorganic composite solution in an electrostatic charge manner; and polymerizing the sprayed organic-inorganic composite solution to form a hydrogel phase.

2 . The method of claim 1 ,
wherein the weight ratio of the inorganic member dispersed in the organic member solution to the organic member is 5 to 10.

3 . The method of claim 1 , further comprising,
after forming the organic-inorganic composite solution, dispersing the inorganic member with a rotation and revolution mixer and stirring the resultant composite solution with an ultrasonic mixer.

4 . The method of claim 1 ,
wherein the polymerizing of the organic-inorganic composite solution is performed by dropping sprayed granules to a polymerization-inducing solution.

5 . The method of claim 1 ,
wherein the inorganic member comprises a functional member.

6 . The method of claim 1 , further comprising
supporting a functional member or cells in the formed organic-inorganic composite solution.

7 . The method of claim 1 ,
wherein the concentration of the organic member solution is 0.5-5 wt %.

8 . The method of claim 1 ,
wherein the size of the inorganic member is 20 nm to 10 μm.

9 . The method of claim 3 ,
wherein the dispersing of the inorganic member with a rotation and revolution mixer and stirring the resultant composite solution with an ultrasonic mixer is performed in a range where the temperature of the organic-inorganic composite solution does not exceed 40° C.

10 . The method of claim 1 ,
wherein the spraying of the organic-inorganic composite solution in an electrostatic charge manner is performed by using a micro-granule coater, and the micro-granule coater has a spray nozzle size in the range of 50-1,000 μm, a voltage in the range of 500-2,500 V, a pressure in the range of 100-1,500 mbar, and a vibration frequency in the range of 100-6,000 Hz.

11 . The method of claim 1 ,
wherein the hydrogel phase does not comprise a dispersant.

12 . The method of claim 1 , further comprising
washing and drying the formed hydrogel phase; and sintering the washed and dried hydrogel phase.

13 . The method of claim 1 ,
wherein the organic member comprises at least one organic matter among alginate, collagen, gelatin, chitosan, cellulose, natural polymers, and a biopolymer.

14 . The method of claim 1 ,
wherein the inorganic member comprises at least one among hydroxy apatite (HA), dicalcium phosphate (DCP), tricalcium phosphate (TCP), tetracalcium phosphate (TTCP), and octacalcium phosphate (OCP).

15 . The method of claim 10 ,
wherein the average diameter of the granules is controlled according to change in the spray nozzle size, pneumatic condition and frequency of the micro-granule coater.

16 . The method of claim 1 ,
the polymerizing is performed by any one among ion crosslinking, chemical crosslinking, and photo crosslinking.

17 . The method of claim 16 ,
wherein the ion crosslinking uses at least one polymerization-inducing material among calcium chloride (CaCl 2 )), calcium sulfate (CaSO 4 ), and calcium carbonate (CaCO 3 ).

18 . The method of claim 12 ,
wherein the sintering is performed at a temperature range of 1000-1300° C. to remove the organic member.

19 . The method of claim 12 ,
wherein the size and porosity of the granules are controlled according to the content of the inorganic member to the organic member.

20 . The method of claim 12 ,
wherein the produced granules are granulated particles comprising calcium oxide (CaO) and the content of the calcium oxide is 1 to 10 mass %.

Assignees

• Korea Inst Mach & Materials

Inventors

• Yun Hui Suk
• Park Honghyun

Classifications

• A61L2400/12

  Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces · CPC title

• A61L2400/06

  Flowable or injectable implant compositions · CPC title

• A61L27/12

  Phosphorus-containing materials, e.g. apatite · CPC title

• A61L27/56

  Porous materials, {e.g. foams or sponges} · CPC title

• A61L2430/34

  for soft tissue reconstruction · CPC title