Spinal cord modulation for inducing paresthetic and anesthetic effects, and associated systems and methods

Patent metadata

Field	Value
Publication number	US-2020171309-A1
Application number	US-201916670712-A
Country	US
Kind code	A1
Filing date	Oct 31, 2019
Priority date	Apr 22, 2009
Publication date	Jun 4, 2020
Grant date	—

Abstract

Spinal cord modulation for inducing paresthetic and anesthetic effects, and associated systems and methods are disclosed. A representative method in accordance with an embodiment of the disclosure includes creating a therapeutic effect and a sensation in a patient by delivering to the patient first pulses having a first set of first signal delivery parameters and second pulses having a second set of second signal delivery parameters, wherein a first value of at least one first parameter of the first set is different than a second value of a corresponding second parameter of the second set, and wherein the first pulses, the second pulses or both the first and second pulses are delivered to the patient's spinal cord.

First claim

1 - 60 . (cancelled)

61 . A patient treatment system, comprising:
a pulse generator that, in operation:
generates bursts of low frequency pulses, wherein each burst of low frequency pulses includes at least two bi-phasic pulses having a frequency in a first frequency range of 2 Hz to 1.2 kHz, and
generates high frequency pulses between sequential bursts of the low frequency pulses, wherein the high frequency pulses (i) have a frequency in a second frequency range of 1.5 kHz to 100 kHz, and (ii) do not generate paresthesia when delivered to a patient; and
an implantable signal delivery device having a plurality of electrodes electrically coupleable to the pulse generator and designed to be implanted within a patient's epidural space, proximate to one or more target neural populations of the patient's spinal cord.

62 . The patient treatment system of claim 61 , wherein each low frequency bi-phasic pulse comprises an anodic pulse and a cathodic pulse, and wherein at least one of the anodic pulse or the cathodic pulse has a pulse width within a pulse width range from 10 microseconds to 1,000 microseconds.

63 . The patient treatment system of claim 61 , wherein each low frequency bi-phasic pulse comprises an anodic pulse and a cathodic pulse, and wherein at least one of the anodic pulse or the cathodic pulse has a pulse width within a pulse width range from 100 microseconds to 1,000 microseconds.

64 . The patient treatment system of claim 61 , wherein the low frequency pulses have a first pulse width and the high frequency pulses have a second pulse width shorter than the first pulse width.

65 . The patient treatment system of claim 61 , wherein the low frequency pulses are selected to induce paresthesia in the patient.

66 . The patient treatment system of claim 61 , wherein a burst comprises three bi-phasic low frequency pulses.

67 . The patient treatment system of claim 61 , wherein, in operation, the pulse generator directs the bursts of low frequency pulses to a first electrode of the plurality of electrodes and the high frequency pulses to a second electrode of the plurality of electrodes different than the first electrode.

68 . The patient treatment system of claim 61 , wherein, in operation, the pulse generator directs the bursts of low frequency pulses and the high frequency pulses to a common electrode of the plurality of electrodes.

69 . The patient treatment system of claim 61 , wherein an amplitude of the low frequency pulses is the same as an amplitude of the high frequency pulses.

70 . A patient treatment system, comprising:
a pulse generator that, in operation:
generates bursts of first pulses, wherein each burst of first pulses includes at least two first pulses having a frequency in a first frequency range of 2 Hz to 1.2 kHz, and
generates second pulses between sequential bursts of the first pulses, wherein the second pulses (i) have a frequency in a second frequency range of 1.5 kHz to 100 kHz, and (ii) do not generate paresthesia when delivered to a patient; and
an implantable signal delivery device having a plurality of electrodes electrically coupleable to the pulse generator and designed to be implanted within a patient's epidural space, proximate to one or more target neural populations of the patient's spinal cord.

71 . The patient treatment system of claim 70 , wherein each of the at least two first pulses have a pulse width within a pulse width range from 10 microseconds to 1,000 microseconds.

72 . The patient treatment system of claim 70 , wherein each of the at least two first pulses have a pulse width within a pulse width range from 100 microseconds to 1,000 microseconds.

73 . The patient treatment system of claim 70 , wherein the bursts of first pulses are selected to induce paresthesia.

74 . The patient treatment system of claim 70 , wherein each burst of first pulses includes three first pulses.

75 . A patient treatment system, comprising:
a pulse generator coupleable to an implantable signal delivery device and having a controller, wherein at least one of the pulse generator or the controller is programmed with instructions that:
generate a burst stimulus comprising first paired pulses having the same polarity, wherein the first paired pulses have a frequency between 2 Hz and 1.2 kHz;
generate a high frequency stimulus comprising second paired pulses having the same polarity, wherein the second paired pulses (i) have a frequency between 1.5 kHz and 50 kHz, and (ii) do not generate paresthesia when delivered to a patient; and
direct the burst stimulus and the high frequency stimulus to the implantable signal delivery device in cycles.

76 . The patient treatment system of claim 75 , wherein the controller is programmed with instructions that direct the burst stimulus and the high frequency stimulus to the implantable signal delivery device in cycles such that delivery of the burst stimulus to the implantable signal delivery device does not temporally overlap with delivery of the high frequency stimulus to the implantable signal delivery device.

77 . The patient treatment system of claim 75 , wherein each pulse of the first paired pulses and the second paired pulses comprises a bi-phasic pulse.

78 . The patient treatment system of claim 75 , wherein at least one pulse of the first paired pulses has a pulse width in a pulse width range from 10 microseconds to 1,000 microseconds.

79 . The patient treatment system of claim 75 , wherein at least one pulse of the second paired pulses has a pulse width in a pulse width range from 10 microseconds to 333 microseconds.

80 . The patient treatment system of claim 75 , wherein the second paired pulses have a frequency between 5 kHz and 15 kHz.

81 . A method for configuring a patient treatment system to deliver a therapy signal to a target neural population at a patient's spinal cord, the method comprising:
programming a signal generator of the patient treatment system to:
generate bursts of low frequency pulses comprising at least one pair of pulses having the same polarity, wherein the at least one pair of pulses has a frequency between 2 Hz and 1.2 kHz;
generate high frequency pulses between sequential bursts of the low frequency pulses, wherein the high frequency pulses have a frequency between 1.5 kHz and 50 kHz; and
deliver the bursts of low frequency pulses and the high frequency pulses to the target neural population in cycles, wherein the high frequency pulses do not generate paresthesia when delivered to the target neural population.

82 . The method of claim 81 , further comprising programming the signal generator to deliver the bursts of low frequency pulses and the high frequency pulses to the target neural population in cycles such that delivery of the bursts of low frequency pulses does not temporally overlap with delivery of the high frequency pulses.

83 . The method of claim 81 , wherein the low frequency pulses and the high frequency pulses are bi-phasic pulses.

84 . The method of claim 81 , wherein each low frequency pulse has a pulse width within a pulse width range from 10 microseconds to 1,000 microseconds.

85 . The method of claim 81 , wherein each high frequency pulse has a pulse width within a pulse width range from 10 microseconds to 333 microseconds.

86 . The method of claim 81 , wherein the low frequency pulses have a first pulse width an

Assignees

• Nevro Corp

Inventors

• Alataris Konstantinos
• Walker Andre B
• Parker Jon

Classifications

• A61N1/36021

  for treatment of pain · CPC title

• A61N1/36132

  using patient feedback · CPC title

• A61N1/06

  for high-frequency therapy · CPC title

• A61N1/3615

  Intensity · CPC title

• A61N1/36178

  Burst or pulse train parameters · CPC title