Bubblyte

Patent metadata

Field	Value
Publication number	US-2020170952-A1
Application number	US-201816618011-A
Country	US
Kind code	A1
Filing date	May 31, 2018
Priority date	Jun 1, 2017
Publication date	Jun 4, 2020
Grant date	—

Abstract

A preparation comprised of one or more pellets having an outer shell and core. The outer shell is made of dissolvable material and said core containing poly (ethylene glycol).

First claim

What is claimed is:

1 . A preparation comprising: a pellet having an outer shell and core, said outer shell made of a dissolvable material and said core containing PEG-3350.

2 . The preparation of claim 1 wherein said dissolvable material is a hydrogel.

3 . The preparation of claim 2 wherein said hydrogel is composed of chitosan and alginate.

4 . The preparation of claim 2 wherein said hydrogel is composed of chitosan and alginate which are cross-linked to encapsulate the PEG-3350.

5 . The preparation of claim 1 wherein the preparation is pH responsive.

6 . The preparation of claim 1 wherein the preparation is pH responsive at a pH of 1-3.

7 . The preparation of claim 4 further including a plurality of pellets, each of said pellet contains 17 g of PEG 3350, sulfate, 0.518 g of sodium bicarbonate, 0.451 g of sodium chloride, and 0.228 g of potassium chloride.

8 . The preparation of claim 4 wherein the preparation is configured to form a mesh, said mesh swells at a pH of 1-3 to release said PEG-3350 from said core.

9 . The preparation of claim 8 wherein the preparation releases said PEG-3350 as the hydrogel swells and the mesh widens causing said PEG-3350 to be released from said core.

10 . A preparation comprising: a pellet having an outer shell and core, said outer shell made of a dissolvable material and said core containing poly(ethylene glycol).

11 . The preparation of claim 10 wherein said dissolvable material is a hydrogel.

12 . The preparation of claim 11 wherein said outer shell of said hydrogel is composed of chitosan and alginate.

13 . The preparation of claim 11 wherein said outer shell of the hydrogel is composed of chitosan and alginate which are cross-linked to encapsulate said poly(ethylene glycol).

14 . The preparation of claim 10 wherein the preparation is pH responsive.

15 . The preparation of claim 10 wherein the preparation is pH responsive at a pH of 1-3.

16 . The preparation of claim 13 further including a plurality of pellets, each of said pellet contains 17 g of poly(ethylene glycol), sulfate, 0.518 g of sodium bicarbonate, 0.451 g of sodium chloride, and 0.228 g of potassium chloride.

17 . The preparation of claim 13 wherein the preparation is configured to swell at a pH of 1-3 to release said poly(ethylene glycol) from said core.

18 . The preparation of claim 17 wherein the preparation releases said poly(ethylene glycol) as the hydrogel swells and the mesh widens causing said poly(ethylene glycol) to be released from said core.

19 . A method of bowel preparation for colonoscopies comprising the steps of: administering an effective amount of a preparation, said preparation comprising a pellet having an outer shell and core, said outer shell made of a dissolvable material and said core containing poly(ethylene glycol).

20 . The method of claim 19 wherein said dissolvable material is a hydrogel and said preparation releases said poly(ethylene glycol) as said hydrogel swells and a mesh formed by said hydrogel widens causing said poly(ethylene glycol) to be released from said core.

21 . The method of claim 20 further including the step of administering an effective amount of a liquid that triggers the swelling of the mesh formed by said hydrogel.

22 . The method of claim 20 further including the step of administering an effective amount of a liquid having a pH that triggers the swelling of the mesh formed by said hydrogel.

Assignees

• Stc Unm
• Univ Swinburne Technology

Inventors

• Canavan Heather
• Nguyen Phuong Anh
• Mcarthur Sally
• Cuylear Darnell Leon

Classifications

• A61K33/00

  Medicinal preparations containing inorganic active ingredients · CPC title

• A61K9/5036

  Polysaccharides, e.g. gums, alginate; Cyclodextrin · CPC title

• A61K9/1641 Primary

  obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers · CPC title

• A61K33/14

  Alkali metal chlorides; Alkaline earth metal chlorides · CPC title

• A61K9/0095

  Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches (A61K9/0007 takes precedence; eatable gels or foams A61K9/0056; oral mucosa adhesive forms A61K9/006) · CPC title