Core-satellite nanocomposites for mri and photothermal therapy

Patent metadata

Field	Value
Publication number	US-2020164094-A1
Application number	US-201916694715-A
Country	US
Kind code	A1
Filing date	Nov 25, 2019
Priority date	Sep 5, 2013
Publication date	May 28, 2020
Grant date	—

Abstract

The present invention provides methods, compositions, systems, and kits comprising core-satellite nanocomposites useful for photothermal and/or MRI applications (e.g., tumor treatment and/or imaging). In certain embodiments, the core-satellite nanocomposites comprise: i) a core nanoparticle complex comprising a biocompatible coating surrounding a nanoparticle core, and ii) at least one satellite component attached to, or absorbed to, the biocompatible coating. In some embodiments, the nanoparticle core and satellite component are composed of near-infrared photothermal agent material and/or MRI contrast agent material. In further embodiments, the satellite component is additionally or alternatively composed of near-infrared optical dye material.

First claim

1 - 20 . (canceled)

21 . A composition comprising a plurality of core-satellite nanocomposites, wherein said core-satellite nanocomposites individually comprise:
a) a core nanoparticle complex comprising a biocompatible coating surrounding a nanoparticle core, wherein said biocompatible coating comprises polysiloxane, wherein said nanoparticle core comprises Fe 3 O 4 and has a diameter between 4 and 60 nm, and b) a plurality of satellite components attached to, or absorbed to, said biocompatible coating, wherein each of said satellite components comprises a gold, or gold-sulfide, nanoparticle with a diameter between 2 and 5 nm; and wherein said plurality of satellite components are visible as discrete nanoparticles, that are not part of a shell surrounding said core nanoparticle complex, using a transmission electron microscope (TEM).

22 . The composition of claim 21 , further comprising a physiologically compatible aqueous solution.

24 . The composition of claim 21 , wherein said Fe3O4 is highly crystallized and has an X-ray diffraction (XRD) pattern where the brightest diffraction ring is from the 440 plane.

25 . The composition of claim 21 , wherein said nanoparticle core has a spherical shape.

26 . The composition of claim 21 , wherein said nanoparticle core has a cubic shape.

Assignees

• Univ Michigan Regents

Inventors

• Chen Hongwei
• Sun Duxin

Classifications

• A61B5/0075

  by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy (A61B5/0071 takes precedence) · CPC title

• A61N2005/0659

  infrared · CPC title

• G01R33/5601

  involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent · CPC title

• A61B5/0035

  adapted for acquisition of images from more than one imaging mode, e.g. combining MRI and optical tomography · CPC title

• A61K41/0052 Primary

  Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy · CPC title