Probenecid for use in treating epileptic diseases, disorders or conditions

US2020163916A1 · US · A1

Patent metadata
FieldValue
Publication numberUS-2020163916-A1
Application numberUS-201816630114-A
CountryUS
Kind codeA1
Filing dateJul 13, 2018
Priority dateJul 13, 2017
Publication dateMay 28, 2020
Grant date

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  1. Title

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  2. Abstract

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  4. Key dates

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  5. First independent claim

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  6. CPC / IPC classifications

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Abstract

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Probenecid or a pharmaceutical acceptable salt thereof for use in the treatment of a neurological disorder in a subject in need thereof, wherein administration of probenecid or a pharmaceutical acceptable salt thereof controls clinical or electrographic seizures in the subject. Preferably, the neurological disorder is an epileptic disease, disorder or condition.

First claim

Opening claim text (preview).

1 - 14 . (canceled) 15 . A method for treating a neurological disorder in a subject in need thereof, comprising administering to the subject probenecid or a pharmaceutical acceptable salt thereof, wherein the administration to the subject of probenecid or a pharmaceutical acceptable salt thereof controls clinical or electrographic seizures in said subject. 16 . The method according to claim 15 , wherein the neurological disorder is an epileptic disease, disorder or condition. 17 . The method according to claim 16 , wherein the epileptic disease, disorder or condition is selected from the group consisting of familial epilepsy, genetic epilepsy, structural/metabolic epilepsy and epilepsies with unknown cause. 18 . The method according to claim 16 , wherein the epileptic disease, disorder or condition is brain tumor-related epilepsy. 19 . The method according to claim 16 , wherein the epileptic disease, disorder or condition is a malformation of cortical development (MCD)-related epilepsy. 20 . The method according to claim 16 , wherein the epileptic disease, disorder or condition is a neurodegenerative-related epilepsy. 21 . The method according to claim 16 , wherein the epileptic disease, disorder or condition is a dysimmune epilepsy. 22 . The method according to claim 16 , wherein the subject is suffering from a treatment-resistant epileptic disease, disorder or condition. 23 . The method according to claim 15 , wherein said subject is a child. 24 . The method according to claim 15 , wherein said subject is an adult. 25 . The method according to claim 15 , wherein probenecid or the pharmaceutical acceptable salt thereof is administered to the subject at a dose ranging from 1 mg/kg/day to 100 mg/kg/day. 26 . The method according to claim 15 , wherein probenecid or the pharmaceutical acceptable salt thereof is administered orally or by injection. 27 . The method according to claim 15 , wherein probenecid or a pharmaceutical acceptable salt thereof is comprised within a pharmaceutical composition also comprising a pharmaceutically acceptable carrier or diluent. 28 . The method according to claim 15 , wherein probenecid or a pharmaceutical acceptable salt thereof is comprised within a medicament.

Assignees

Inventors

Classifications

  • A61K31/195Primary

    having an amino group · CPC title

  • Mouth and digestive tract, i.e. intraoral and peroral administration · CPC title

  • Antiepileptics; Anticonvulsants · CPC title

  • Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00) · CPC title

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What does patent US2020163916A1 cover?
Probenecid or a pharmaceutical acceptable salt thereof for use in the treatment of a neurological disorder in a subject in need thereof, wherein administration of probenecid or a pharmaceutical acceptable salt thereof controls clinical or electrographic seizures in the subject. Preferably, the neurological disorder is an epileptic disease, disorder or condition.
Who is the assignee on this patent?
Paris Sciences Lettres Quartier Latin, Centre Nat Rech Scient, Inst Nat Sante Rech Med, and 4 more
What technology area does this patent fall under?
Primary CPC classification A61K31/195. Mapped technology areas include Human Necessities.
When was this patent published?
Publication date Thu May 28 2020 00:00:00 GMT+0000 (Coordinated Universal Time) (A1). Legal status and post-grant events are not shown on this page.
What related patents are in patentsdb?
We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).