Atherosclerosis-targeted liposome nanocarrier delivery system and preparation method therefor
US-2024424132-A1 · Dec 26, 2024 · US
US2020163916A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2020163916-A1 |
| Application number | US-201816630114-A |
| Country | US |
| Kind code | A1 |
| Filing date | Jul 13, 2018 |
| Priority date | Jul 13, 2017 |
| Publication date | May 28, 2020 |
| Grant date | — |
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Probenecid or a pharmaceutical acceptable salt thereof for use in the treatment of a neurological disorder in a subject in need thereof, wherein administration of probenecid or a pharmaceutical acceptable salt thereof controls clinical or electrographic seizures in the subject. Preferably, the neurological disorder is an epileptic disease, disorder or condition.
Opening claim text (preview).
1 - 14 . (canceled) 15 . A method for treating a neurological disorder in a subject in need thereof, comprising administering to the subject probenecid or a pharmaceutical acceptable salt thereof, wherein the administration to the subject of probenecid or a pharmaceutical acceptable salt thereof controls clinical or electrographic seizures in said subject. 16 . The method according to claim 15 , wherein the neurological disorder is an epileptic disease, disorder or condition. 17 . The method according to claim 16 , wherein the epileptic disease, disorder or condition is selected from the group consisting of familial epilepsy, genetic epilepsy, structural/metabolic epilepsy and epilepsies with unknown cause. 18 . The method according to claim 16 , wherein the epileptic disease, disorder or condition is brain tumor-related epilepsy. 19 . The method according to claim 16 , wherein the epileptic disease, disorder or condition is a malformation of cortical development (MCD)-related epilepsy. 20 . The method according to claim 16 , wherein the epileptic disease, disorder or condition is a neurodegenerative-related epilepsy. 21 . The method according to claim 16 , wherein the epileptic disease, disorder or condition is a dysimmune epilepsy. 22 . The method according to claim 16 , wherein the subject is suffering from a treatment-resistant epileptic disease, disorder or condition. 23 . The method according to claim 15 , wherein said subject is a child. 24 . The method according to claim 15 , wherein said subject is an adult. 25 . The method according to claim 15 , wherein probenecid or the pharmaceutical acceptable salt thereof is administered to the subject at a dose ranging from 1 mg/kg/day to 100 mg/kg/day. 26 . The method according to claim 15 , wherein probenecid or the pharmaceutical acceptable salt thereof is administered orally or by injection. 27 . The method according to claim 15 , wherein probenecid or a pharmaceutical acceptable salt thereof is comprised within a pharmaceutical composition also comprising a pharmaceutically acceptable carrier or diluent. 28 . The method according to claim 15 , wherein probenecid or a pharmaceutical acceptable salt thereof is comprised within a medicament.
having an amino group · CPC title
Mouth and digestive tract, i.e. intraoral and peroral administration · CPC title
Antiepileptics; Anticonvulsants · CPC title
Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00) · CPC title
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