Organic polymer particles containing poly(oxazoline) stabilizers and use of poly(oxazolines) for stabilizing organic polymer particles

Patent metadata

Field	Value
Publication number	US-2020122106-A1
Application number	US-201816493368-A
Country	US
Kind code	A1
Filing date	Mar 12, 2018
Priority date	Mar 14, 2017
Publication date	Apr 23, 2020
Grant date	—

Abstract

The invention relates to compositions containing water-soluble poly(oxazoline) and organic polymer particles chosen from the group of polyolefins, polyvinyl aromatics, polyvinyl esters, polyesters, polyamides, polyimides, polycarboxylic acids, polycarboxilic acid esters, polycarboxylic acid amides, polynitriles, polysulfonic acids, polyketones, polysulfones, polymeric polyols, polyurethanes, proteins, polymeric carbohydrates, nucleic acids or from a mixture of two or more of these polymers. The water-soluble poly(oxazolin) acts as a stabilizer for the polymer particles and can particularly advantageously be used as a stabilizer in the freeze-drying of aqueous polymer dispersions.

First claim

1 .- 7 . (Canceled)

8 . Compositions containing water-soluble poly(oxazoline) and organic polymer particles, characterized in that the organic polymer particles comprise a polyester.

9 . Compositions according to claim 8 , characterized in that the polyester is a polyhydroxyalkanoate.

10 . Compositions according to claim 9 , characterized in that the polyhydroxyalkanoate is a lactic acid homo- or copolymer.

11 . (canceled)

12 . (canceled)

13 . (canceled)

14 . Compositions containing water-soluble poly(oxazoline) and organic polymer particles selected from the group of polyolefins, polyvinylaromatics, polyvinyl esters, polyesters, polyamides, polyimides, polycarboxylic acids, polycarboxylic acid esters, polycarboxylic acid amides, polynitriles, polysulfonic acids, polyketones, polysulfones, polymeric polyols, polyurethanes, proteins, polymeric carbohydrates, nucleic acids or a mixture of two or more of these polymers, characterized in that the organic polymer particles contain one or more pharmaceutically active substances.

15 . (canceled)

16 . (canceled)

17 . (canceled)

18 . (canceled)

19 . The compositions according to claim 8 , wherein the mean diameter D 50 of the organic polymer particles is less than 10 μm.

20 . Compositions according to claim 19 , wherein the mean diameter D 50 of the organic polymer particles is less than 1 μm.

21 . Compositions according to 8, wherein the organic polymer particles have diameters in the range of 50 to 999 nm.

22 . Compositions according to claim 8 , wherein the organic polymer particles form a dispersed phase in a hydrophilic liquid.

23 . Compositions according to claim 8 , wherein the organic polymer particles are suspended in a hydrophilic liquid.

24 . Compositions according to claim 14 , wherein the organic polymer particles are in solid form and are coated by the poly(oxazoline).

25 . The compositions according to claim 14 , wherein the mean diameter D 50 of the organic polymer particles is less than 10 μm.

26 . Compositions according to claim 25 , wherein the mean diameter D 50 of the organic polymer particles is less than 1 μm.

27 . Compositions according to 14, wherein the organic polymer particles have diameters in the range of 50 to 999 nm.

28 . Compositions according to claim 14 , wherein the organic polymer particles form a dispersed phase in a hydrophilic liquid.

29 . Compositions according to claim 14 , wherein the organic polymer particles are suspended a hydrophilic liquid.

30 . Compositions according to claim 14 , wherein the organic polymer particles are in solid form and are coated by the poly(oxazoline)

31 . Compositions according to claim 14 , wherein the organic polymer particles comprise a polyester.

Assignees

• Univ Jena Friedrich Schiller

Inventors

• Leiske Meike Nicole
• Traeger Anja
• Schubert Ulrich Sigmar

Classifications

• C08L67/04

  Polyesters derived from hydroxycarboxylic acids, e.g. lactones (C08L67/06 takes precedence) · CPC title

• C09D167/04

  Polyesters derived from hydroxycarboxylic acids, e.g. lactones (C09D167/06 takes precedence) · CPC title

• C08G73/0233

  Polyamines derived from (poly)oxazolines, (poly)oxazines or having pendant acyl groups · CPC title

• C09D133/062

  Copolymers with monomers not covered by C09D133/06 · CPC title

• C09D7/45

  Anti-settling agents · CPC title