Process for Making Cyano Functionalized Gold Nanoparticles

Patent metadata

Field	Value
Publication number	US-2020116640-A1
Application number	US-201816157574-A
Country	US
Kind code	A1
Filing date	Oct 11, 2018
Priority date	Oct 11, 2018
Publication date	Apr 16, 2020
Grant date	—

Abstract

A cyanide-functionalized gold nanoparticle. A method of making cyanide-functionalized gold nanoparticles includes forming an aqueous reaction mixture comprising a gold precursor and glycine, keeping the reaction mixture at about 18° C. to about 50° C. for at least 6 days to provide formation of the cyanide-functionalized gold nanoparticles, and isolating the cyanide-functionalized gold nanoparticles from the reaction mixture. A method of analyzing a sample, comprising contacting cyanide-functionalized gold nanoparticles with the sample and performing an analytical method on the sample. A sensor comprises cyanide-functionalized gold nanoparticles.

First claim

What is claimed is:

1 . A cyanide-functionalized gold nanoparticle.

2 . The cyanide-functionalized gold nanoparticle of claim 1 , having an average diameter of about 10 to about 200 nm.

3 . The cyanide-functionalized gold nanoparticle of claim 1 , wherein the cyanide covers about 0.1% to about 40% of the nanoparticle surface.

4 . A method of making cyanide-functionalized gold nanoparticles, the method comprising:
forming an aqueous reaction mixture comprising a gold precursor and glycine, keeping the reaction mixture at about 18° C. to about 50° C. for at least 6 days to provide formation of the cyanide-functionalized gold nanoparticles, and isolating the cyanide-functionalized gold nanoparticles from the reaction mixture.

5 . The method of claim 4 , wherein keeping the reaction mixture about 18° C. to about 50° C. for at least 6 days is done in the dark without stirring.

6 . The method of claim 4 , wherein the gold precursor comprises K[AuCl 4 ], chloroauric acid, gold (III) chloride; gold (III) iodide, trichloro(pyridine)gold(III), chloro(triphenylphosphine)gold(I), gold(I) cyanide, gold(III) bromide, gold(I) sulfide, gold(III) hydroxide, chloro(triethylphosphine)gold(I), methyl(triphenylphosphine)gold(I), or a salt thereof.

7 . The method of claim 4 , wherein the pH of the reaction mixture is about 7 to about 14.

8 . The method of claim 4 , wherein the reaction mixture comprises 0.001 to 1 wt % of the gold salt, and 0.001 to 1 wt % of the glycine, based on the weight of the reaction mixture.

9 . The method of claim 4 , further comprising monitoring the formation of the cyanide-functionalized gold nanoparticles by UV-visible spectroscopy, dynamic light scattering particle analysis, Raman spectroscopy, or a combination comprising at least one of the foregoing.

10 . The method of claim 4 , wherein the cyanide-functionalized gold nanoparticles have an average diameter of about 10 to about 200 nm.

11 . The method of claim 4 , wherein the cyanide covers about 0.1% to about 40% of the nanoparticle surface.

12 . A method of analyzing a sample, comprising contacting cyanide-functionalized gold nanoparticles with the sample and performing an analytical method on the sample.

13 . The method of claim 12 , wherein the cyanide-functionalized gold nanoparticles provide an internal reference; and wherein the analytical method comprises radiating the sample contacted with the cyanide-functionalized gold nanoparticles with electromagnetic radiation; measuring a Raman spectrum emitted from the sample; and determining the presence or a concentration of a selected chemical in the sample from the Raman spectrum, wherein the cyanide-functionalized gold nanoparticles provide an internal reference at about 2,100 cm −1 .

14 . The method of claim 13 , wherein the analytical method is SERS.

15 . The method of claim 12 , wherein the cyanide-functionalized gold nanoparticles are in the form of a sol, a gel, a substrate comprising a support layer, or a matrix.

16 . The method of claim 12 , wherein the cyanide-functionalized gold nanoparticles have an average diameter of about 10 to about 200 nm.

17 . The method of claim 12 , wherein the sample is a biological sample, and the method comprises detecting a biological analyte in the biological sample.

18 . A sensor comprising the cyanide-functionalized gold nanoparticle of claim 1 .

19 . The sensor of claim 18 , wherein the sensor 200 comprises an optically sensitive material 202 comprising the cyanide-functionalized gold nanoparticles, and wherein the optically sensitive material 202 is dispersed in a matrix material 204 .

20 . The sensor of claim 18 , wherein the sensor 100 comprises electrodes 10 and the cyanide-functionalized gold nanoparticles 30 bridging a gap between the electrodes 30 .

Assignees

• Suresh Radhika
• Murugesan Sankaran
• Khabashesku Valery N
• Darugar Qusai
• Baker Hughes A Ge Co Llc

Inventors

• Suresh Radhika
• Murugesan Sankaran
• Khabashesku Valery N
• Darugar Qusai

Classifications

• G01N21/658 Primary

  enhancement Raman, e.g. surface plasmons · CPC title

• G01N21/78

  producing a change of colour · CPC title

• G01N21/65

  Raman scattering · CPC title

• B22F9/24

  starting from liquid metal compounds, e.g. solutions · CPC title

• G01N33/5438

  Electrodes · CPC title