Piperidine compounds, pharmaceutical composition comprising the same and its use
US-2016362374-A1 · Dec 15, 2016 · US
New method for preparing donepezil pamoate
US2020087256A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2020087256-A1 |
| Application number | US-201816618896-A |
| Country | US |
| Kind code | A1 |
| Filing date | Jun 5, 2018 |
| Priority date | Jun 5, 2017 |
| Publication date | Mar 19, 2020 |
| Grant date | — |
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Abstract
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Disclosed is a new method for preparing a donepezil pamoate (1-benzyl-4-[(5,6-dimethoxyindan-2-one)methyl]piperidine pamoate). The donepezil pamoate prepared by using the method has a high purity and a good flowability.
First claim
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1 . A method for preparing a crystal form A of a compound of formula I, comprising dissolving the compound of formula I in a reaction solvent and adding another solvent dropwise for precipitation to give the crystal form A of the compound of formula I. 2 . The method according to claim 1 , wherein the reaction solvent is one selected from the group consisting of alcohols, ethers, esters, ketones, nitriles, alkanes and water, or a combination thereof. 3 . The method according to claim 1 , wherein the reaction solvent is ketones. 4 . The method according to claim 1 , wherein the reaction solvent is acetone. 5 . The method according to claim 1 , wherein dissolving is carried out at a temperature of from 0 to 50° C. 6 . The method according to claim 1 , wherein dissolving is carried out at a temperature of from 15 to 30° C. 7 . The method according to claim 1 , wherein another solvent is one selected from the group consisting of alcohols, ethers, esters, ketones, nitriles, alkanes and water, or a combination thereof. 8 . The method according to claim 1 , wherein another solvent is water. 9 . The method according to claim 1 , wherein adding another solvent dropwise is carried out at a temperature of 0 to 50° C. 10 . The method according to claim 1 , wherein adding another solvent dropwise is carried out at a temperature of 15 to 30° C.
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containing two carboxyl groups both bound to carbon atoms of the condensed ring system · CPC title
for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia · CPC title
- C07D211/32Primary
by oxygen atoms · CPC title
by change of the physical state, e.g. crystallisation · CPC title
Crystalline forms, e.g. polymorphs · CPC title
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Frequently asked questions
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- What does patent US2020087256A1 cover?
- Disclosed is a new method for preparing a donepezil pamoate (1-benzyl-4-[(5,6-dimethoxyindan-2-one)methyl]piperidine pamoate). The donepezil pamoate prepared by using the method has a high purity and a good flowability.
- Who is the assignee on this patent?
- Zhejiang Huahai Pharm Co Ltd, Shanghai Aobo Pharmtech Inc Ltd
- What technology area does this patent fall under?
- Primary CPC classification C07D211/32. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Thu Mar 19 2020 00:00:00 GMT+0000 (Coordinated Universal Time) (A1). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).